2019冠状病毒病(COVID-19)基于推荐诊疗方案的中医用药特点分析

doi:10.3785/j.issn.1008-9292.2020.03.14

浙江大学学报（医学版）

2020, Vol. 49

Issue (2): 260-269 DOI: 10.3785/j.issn.1008-9292.2020.03.14

原著

2019冠状病毒病(COVID-19)基于推荐诊疗方案的中医用药特点分析

范天田¹(

),陈永灿^2,*(

),白钰²,马凤岐²,王恒苍²,杨益萍²,陈金旭¹,林雨琪¹

1. 浙江中医药大学基础医学院, 浙江杭州 310053
2. 浙江省立同德医院, 浙江杭州 310007

Analysis of medication characteristics of traditional Chinese medicine in treating COVID-19 based on data mining

FAN Tiantian¹(

),CHEN Yongcan^2,*(

),BAI Yu²,MA Fengqi²,WANG Hengcang²,YANG Yiping²,CHEN Jinxu¹,LIN Yuqi¹

1. College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China
2. Tongde Hospital of Zhejiang Province, Hangzhou 310007, China

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摘要：

目的: 分析国家卫生健康委员会（卫健委）、国家中医药管理局（中管局）及各省市自治区卫健委、中管局通过公开渠道发布的2019冠状病毒病（COVID-19）治疗方案中中医药处方用药特点。方法: 收集自我国COVID-19疫情发生以来至2020年2月19日国家及各省市自治区卫健委、中管局通过公开渠道发布的COVID-19推荐诊疗方案中中医药相关内容，并进行所有数据的频数分析、关联分析和聚类分析。结果: 共收集国家诊疗方案4个，各省市自治区防治方案34个，样本578条，得到有名称的传统方剂84首，中成药60种，涉及单味药230味。高频用药有甘草、黄芩、杏仁、石膏等，常见方剂有麻杏石甘汤、银翘散、宣白承气汤等，常用中成药有安宫牛黄丸、血必净注射液、连花清瘟胶囊等，高频药对有“麻黄，杏仁”“连翘，甘草”等，挖掘出核心药物组合2个，新处方1个。结论: COVID-19卫分证以银翘散、藿朴夏苓汤为基础方，气分证可以麻杏石甘汤、凉膈散、清瘟败毒饮、达原饮等为基础方。用药特点以宣肺清热、解毒祛浊为主，体现中医治疫解毒透邪的处方思路。

关键词： 2019冠状病毒病; 严重急性呼吸综合征冠状病毒2; 新型冠状病毒肺炎; 中医药治疗; 数据挖掘; 频数分析; 关联分析; 聚类分析

Abstract:

Objective: To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). Methods: We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. The frequency analysis, cluster analysis and association analysis were performed. Results: The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. The high frequently used herbs were Liquorice, Scutellariabaicalensis, Semen armeniacaeamarae, and Gypsum. The commonly used traditional formulations included Maxing Shigan decoction, Yin Qiao powder, and Xuanbai Chengqi decoction. The Chinese patent drugs included Angong Niuhuang pill, Xuebijing injection, and Lianhua Qingwen capsule. The most common paired medications were Ephedra and Semen armeniacaeamarae, Fructusforsythiae and Liquorice. Two core combinations and one novel formula were discovered in the study. Conclusions: Yin Qiao powder and Huopo Xialing decoction are the basic formulations for Weifen syndrome of COVID-19. In addition, Maxing Shigan decoction, Liang Ge powder, Qingwen Baidu decoction and Da Yuan decoction are the basic formulations for Qifen syndrome of COVID-19. The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. It shows that removing toxicity and eliminating evil are the prescription thought in treating epidemic disease of traditional Chinese medicine.

Key words: Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Novel coronavirus pneumonia Traditional Chinese medicine treatment Data mining Frequency analysis Association analysis Cluster analysis

收稿日期: 2020-02-22 出版日期: 2020-04-03

R243

基金资助: 浙江省名老中医专家传承工作室建设计划(GZS2017002)

通讯作者: 陈永灿 E-mail: 15735649143@163.com;cyc3123@sina.com

作者简介: 范天田(1990—), 女, 博士研究生, 主要从事中医医家学术思想与诊疗经验研究; E-mail:15735649143@163.com; https://orcid.org/0000-0002-8844-7231

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	林雨琪

引用本文:

范天田,陈永灿,白钰,马凤岐,王恒苍,杨益萍,陈金旭,林雨琪. 2019冠状病毒病(COVID-19)基于推荐诊疗方案的中医用药特点分析[J]. 浙江大学学报（医学版）, 2020, 49(2): 260-269.

FAN Tiantian,CHEN Yongcan,BAI Yu,MA Fengqi,WANG Hengcang,YANG Yiping,CHEN Jinxu,LIN Yuqi. Analysis of medication characteristics of traditional Chinese medicine in treating COVID-19 based on data mining. J Zhejiang Univ (Med Sci), 2020, 49(2): 260-269.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.03.14 或 http://www.zjujournals.com/med/CN/Y2020/V49/I2/260

表 1 治疗2019冠状病毒病中医药方案中的高频单味药(频次≥80)

表 2 治疗2019冠状病毒病中医药方案中的高频方剂(频次≥5)

表 3 治疗2019冠状病毒病中医药方案中的高频中成药(频次≥5)

表 4 治疗2019冠状病毒病中医药方案中的关联药物组合(支持度=70，置信度=0.8)

图 1 治疗2019冠状病毒病中药方案中的核心药物组合展示图

图 2 治疗2019冠状病毒病中药方案中的新方网络图

1	中华人民共和国国家卫生健康委员会办公厅, 国家中医药管理局办公室.新型冠状病毒感染的肺炎诊疗方案(试行第三版)[A/OL].国卫办医函〔2020〕66号.(2020-01-22)[2020-02-01].http://www.nhc.gov.cn/xcs/yqfkdt/202001/f492c9153ea9437bb587ce2ffcbee1fa.shtml. General Office of National Health Commission of the People's Republic of China, Office of National Administration of Traditional Chinese Medicine. Diagnosis and treatment of novel coronavirus pneumonia (trial version 3)[A/OL]. No.66〔2020〕of the General Office of the National Health Commission. (2020-01-22)[2020-02-01]. http://www.nhc.gov.cn/xcs/yqfkdt/202001/f492c9153ea9437bb587ce2ffcbee1fa.shtml. (in Chinese)
2	中华人民共和国国家卫生健康委员会办公厅, 国家中医药管理局办公室.新型冠状病毒感染的肺炎诊疗方案(试行第四版)[A/OL].国卫办医函〔2020〕77号.(2020-01-27)[2020-02-01].http://www.nhc.gov.cn/yzygj/s7653p/202001/4294563ed35b43209b31739bd0785e67.shtml. General Office of National Health Commission of the People's Republic of China, Office of National Administration of Traditional Chinese Medicine. Diagnosis and treatment of novel coronavirus pneumonia (trial version 4)[A/OL].No.77〔2020〕of the General Office of the National Health Commission. (2020-01-27)[2020-02-01]. http://www.nhc.gov.cn/yzygj/s7653p/202001/4294563ed35b43209b31739bd0785e67.shtml. (in Chinese)
3	中华人民共和国国家卫生健康委员会办公厅, 国家中医药管理局办公室.新型冠状病毒感染的肺炎诊疗方案(试行第五版)[A/OL].国卫办医函〔2020〕103号.(2020-02-05)[2020-02-10].http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml. General Office of National Health Commission of the People's Republic of China, Office of National Administration of Traditional Chinese Medicine. Diagnosis and treatment of novel coronavirus pneumonia (trial version 5)[A/OL]. No.103〔2020〕of the General Office of the National Health Commission. (2020-02-04)[2020-02-10]. http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml. (in Chinese)
4	中华人民共和国国家卫生健康委员会办公厅, 国家中医药管理局办公室.新型冠状病毒感染的肺炎诊疗方案(试行第六版)[A/OL].国卫办医函〔2020〕145号.(2020-02-18)[2020-02-20].http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aefc2.shtml. General Office of National Health Commission of the People's Republic of China, Office of National Administration of Traditional Chinese Medicine. Diagnosis and treatment of novel coronavirus pneumonia (trial version 6)[A/OL]. No.145〔2020〕of the General Office of the National Health Commission. (2020-02-18)[2020-02-20].http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aefc2.shtml. (in Chinese)
5	北京市中医管理局.北京市新型冠状病毒感染的肺炎中医药防治方案(第二版)[A/OL].(2020-01-29)[2020-01-30].http://zyj.beijing.gov.cn/sy/tzgg/202001/t20200130_1621630.html. Beijing Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Beijing by traditional Chinese medicine (version 2)[A/OL]. (2020-01-29)[2020-01-30].http://zyj.beijing.gov.cn/sy/tzgg/202001/t20200130_1621630.html. (in Chinese)
6	甘肃省卫生健康委员会.甘肃省新型冠状病毒感染的肺炎中医药防治方案(试行)[A/OL].(2020-01-26)[2020-01-28].http://wsjk.gansu.gov.cn/single/11067/83053.html. Health Commission of Gansu Province.Prevention and treatment of novel coronavirus pneumonia in Gansu by traditional Chinese medicine (trail version)[A/OL].(2020-01-26)[2020-01-28].http://wsjk.gansu.gov.cn/single/11067/83053.html. (in Chinese)
7	甘肃省卫生健康委员会.甘肃省新型冠状病毒感染的肺炎中医药防治方案(试行第二版)[A/OL].甘卫中医函〔2020〕63号.(2020-02-01)[2020-02-01].http://wsjk.gansu.gov.cn/file.jsp?contentId=83488. Health Commission of Gansu Province. Prevention and treatment of novel coronavirus pneumonia in Gansu by traditional Chinese medicine (trail version 2)[A/OL]. No.63〔2020〕of the Health Commission of Gansu Province. (2020-02-01)[2020-02-01].http://wsjk.gansu.gov.cn/file.jsp?contentId=83488. (in Chinese)
8	广西壮族自治区中医药管理局.广西壮族自治区新型冠状病毒感染的肺炎中医药治疗方案(试行)[A/OL].桂中医药医发〔2020〕5号.(2020-01-24)[2020-01-25].http://wsjkw.gxzf.gov.cn/zwgk/zfxxgkml/wsjszh/zyzy/2020/0124/1694.html. Guangxi Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Guangxi by traditional Chinese medicine (trial version)[A/OL]. No.5〔2020〕of the Guangxi Administration of Traditional Chinese Medicine. (2020-01-24)[2020-01-25].http://wsjkw.gxzf.gov.cn/zwgk/zfxxgkml/wsjszh/zyzy/2020/0124/1694.html. (in Chinese)
9	广西壮族自治区中医药管理局.广西壮族自治区新型冠状病毒感染的肺炎中医药治疗方案(试行第二版)[A/OL].桂中医药医发〔2020〕8号.(2020-02-08)[2020-02-13].http://wsjkw.gxzf.gov.cn/zwgk/zfxxgkml/wsjszh/zyzy/2020/0213/1725.html. Guangxi Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Guangxi by traditional Chinese medicine (trial version 2)[A/OL]. No.8〔2020〕of the Guangxi Administration of Traditional Chinese Medicine. (2020-02-08)[2020-02-13]. http://wsjkw.gxzf.gov.cn/zwgk/zfxxgkml/wsjszh/zyzy/2020/0213/1725.html. (in Chinese)
10	贵州省中医药管理局.贵州省病毒性肺炎中医药防治参考方案[A].黔中医药函〔2020〕22号, 2020. Guizhou Administration of Traditional Chinese Medicine.Reference plan for the prevention and treatment of viral pneumonia in Guizhou province[A]. No.22〔2020〕of the Guizhou Administration of Traditional Chinese Medicine, 2020. (in Chinese)
11	河北省中医药管理局.河北省新型冠状病毒肺炎中医防治方案(试行第四版)[A/OL].(2020-02-12)[2020-02-12].https://mp.weixin.qq.com/s/9QTqGDw6vkQyWX-VrjulqQ. Hebei Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Hebei by traditional Chinese medicine (trial version 4)[A/OL].(2020-02-12)[2020-02-12].https://mp.weixin.qq.com/s/9QTqGDw6vkQyWX-VrjulqQ. (in Chinese)
12	河北省卫生健康委员会.河北省新型冠状病毒感染的肺炎诊疗方案(试行第二版)[A/OL].(2020-02-01)[2020-02-01].http://www.hebwst.gov.cn/index.do?id=396245&templet=content&cid=3713. Health Commission of Hebei Province.Diagnosis and treatment of novel coronavirus pneumonia in Hebei province (trial version 2)[A/OL]. (2020-02-01)[2020-02-01]. http://www.hebwst.gov.cn/index.do?id=396245&templet=content&cid=3713. (in Chinese)
13	河北省中医药管理局.河北省新型冠状病毒感染的肺炎中医防治方案(试行第三版)[A/OL].(2020-01-31)[2020-01-31].https://mp.weixin.qq.com/s/DC5nE2Gn0d3cZBUaGklpyA. Hebei Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Hebei by traditional Chinese medicine (trial version 3)[A/OL]. (2020-01-31)[2020-01-31].https://mp.weixin.qq.com/s/DC5nE2Gn0d3cZBUaGklpyA. (in Chinese)
14	黑龙江省中医药管理局.黑龙江省新型冠状病毒感染的肺炎中医药防治方案(试行)[A/OL].黑疫领发〔2020〕6号.(2020-02-05)[2020-02-06].http://wsjkw.hlj.gov.cn/index.php/Home/Zwgk/jieguo/newsid/459. Heilongjiang Traditional Chinese Medicine. Prevention and treatment of novel coronavirus pneumonia in Heilongjiang by traditional Chinese medicine (trial version)[A/OL]. No.6〔2020〕of Leading Group of COVID Epidemic Prevention and Control in Heilongjiang Province. (2020-02-05)[2020-02-06]. http://wsjkw.hlj.gov.cn/index.php/Home/Zwgk/jieguo/newsid/459. (in Chinese)
15	黑龙江省中医药管理局.黑龙江省新型冠状病毒感染的肺炎中医药防治方案(第二版)[A].黑中医药发〔2020〕5号, 2020. Heilongjiang Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Heilongjiang by traditional Chinese medicine (version 2)[A].No.5〔2020〕of the Heilongjiang Administration of Traditional Chinese Medicine, 2020. (in Chinese)
16	河北省中医药管理局.河北省新型冠状病毒感染的肺炎中医防治方案(试行第一版)[A].冀中医药函〔2020〕10号, 2020. Hebei Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Hebei by traditional Chinese medicine (trail version 1)[A].No.10〔2020〕of the Hebei Administration of Traditional Chinese Medicine, 2020. (in Chinese)
17	湖南省中医药管理局.湖南省新型冠状病毒感染的肺炎中医药诊疗方案(试行第二版)[A/OL].湘中医药函〔2020〕11号.(2020-01-26)[2020-01-26].http://tcm.hunan.gov.cn/tcm/xxgk/tzgg/202001/t20200126_11164462.html. Hunan Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Hunan by traditional Chinese medicine (trail version 2)[A/OL].No.11〔2020〕of the Hunan Administration of Traditional Chinese Medicine.(2020-01-26)[2020-01-26].http://tcm.hunan.gov.cn/tcm/xxgk/tzgg/202001/t20200126_11164462.html. (in Chinese)
18	吉林省卫生健康委员会.吉林省新型冠状病毒感染肺炎中医药诊疗方案(试行第一版)[A/OL].(2020-01-26)[2020-01-26].http://jltcm.jl.gov.cn/tzgg/xgdt/202001/t20200126_6654768.html. Health Commission of Jilin Province.Prevention and treatment of novel coronavirus pneumonia in Jilin by traditional Chinese medicine (trail version)[A/OL].(2020-01-26)[2020-01-26].http://jltcm.jl.gov.cn/tzgg/xgdt/202001/t20200126_6654768.html. (in Chinese)
19	山西省卫生健康委.山西省新型冠状病毒感染的肺炎中医药防治方案(试行)[A].晋卫办中医药函〔2020〕9号, 2020. Health Commission of Shanxi Province.Prevention and treatment of novel coronavirus pneumonia in Shanxi by traditional Chinese medicine (trail version)[A].No.9〔2020〕of theHealth Commission of Shanxi Province, 2020. (in Chinese)
20	上海市新型冠状病毒感染的肺炎疫情防控工作领导小组办公室.上海市新型冠状病毒感染的肺炎中医诊疗方案(试行)[A].沪肺炎防控办〔2020〕28号, 2020. Leading Group for Prevention and Control of Novel Coronavirus Pneumonia in Shanghai. Prevention and treatment of novel coronavirus pneumonia in Shanghai by traditional Chinese medicine (trail version)[A].No.28〔2020〕of the General Office of Prevention and Control of Novel Coronavirus Pneumonia in Shanghai, 2020. (in Chinese)
21	四川省中医药管理局.四川省新型冠状病毒感染的肺炎中医药干预建议处方(试行第一版)[A/OL].(2020-01-25)[2020-01-25].http://www.sc.gov.cn/10462/12771/2020/1/25/0d37953ca2534d5382ba744e81725469.shtml. Sichuan Administration of Traditional Chinese Medicine. Chinese medicine intervention for pneumonia infected by novel coronavirus in Sichuan province (trial version 1)[A/OL]. (2020-01-25)[2020-01-25]. http://www.sc.gov.cn/10462/12771/2020/1/25/0d37953ca2534d5382ba744e81725469.shtml. (in Chinese)
22	四川省中医药管理局.四川省新型冠状病毒感染的肺炎中医药防控技术指南[A/OL].(2020-02-04)[2020-02-04].http://sctcm.sc.gov.cn/sctcm/gggs/2020/2/5/891d684e02e948128b32547ae2eb8da4.shtml. Sichuan Administration of Traditional Chinese Medicine.Technical guidelines for prevention and control of pneumonia by traditional Chinese medicine in Sichuan province by novel coronavirus[A/OL]. (2020-02-04)[2020-02-04].http://sctcm.sc.gov.cn/sctcm/gggs/2020/2/5/891d684e02e948128b32547ae2eb8da4.shtml. (in Chinese)
23	云南省卫生健康委员会.云南省新型冠状病毒感染的肺炎中医药防治方案(试行第二版)[A/OL].(2020-02-11)[2020-02-11].http://ynswsjkw.yn.gov.cn/wjwWebsite/web/doc/UU158140615448559052. Health Commission of Yunnan Province.Prevention and treatment of novel coronavirus pneumonia in Shanxi by traditional Chinese medicine (trail version 2)[A/OL].(2020-02-11)[2020-02-11].http://ynswsjkw.yn.gov.cn/wjwWebsite/web/doc/UU158140615448559052. (in Chinese)
24	浙江省新冠肺炎省级医疗救治专家组.新型冠状病毒感染的肺炎诊疗方案(浙江临床经验版第一版)[A].2020. Zhejiang Provincial Novel Coronavirus Pneumonia Provincial Medical Treatment Expert Group. Diagnosis and treatment of novel coronavirus pneumonia (Zhejiang clinical experience, version 1)[A]. 2020. (in Chinese)
25	江苏省卫生健康委员会.江苏省新型冠状病毒肺炎中医辨治方案(试行第三版)[A].苏防救治〔2020〕21号, 2020. Jiangsu Commission of Health.Traditional chinese medicine syndrome differentiation treatment of novel coronavirus pneumonia in Jiangsu province (trial version 3)[A].No.21〔2020〕of the Leading Group of Prevention and Control of novel coronavirus pneumonia in Jiangsu province, 2020. (in Chinese)
26	江西省中医药管理局.江西省新型冠状病毒感染的肺炎中医药防治方案(试行)[A/OL].(2020-01-24)[2020-01-25].http://www.jxhfpc.gov.cn/doc/2020/01/25/138468.shtml. Jiangxi Administration of Traditional Chinese Medicine.Prevention and treatment of novel coronavirus pneumonia in Jiangxi by traditional Chinese medicine (trail version)[A/OL].(2020-01-24)[2020-01-25].http://www.jxhfpc.gov.cn/doc/2020/01/25/138468.shtml. (in Chinese)
27	宁夏回族自治区卫生健康委员会.宁夏回族自治区新型冠状病毒感染的肺炎中医药防治方案(试行)[A/OL].(2020-01-28)[2020-01-28].http://wsjkw.nx.gov.cn/info/1040/13360.htm. Health Commission of Ningxia Hui Autonomous Region.Prevention and treatment of novel coronavirus pneumonia in Ningxia by traditional Chinese medicine (trail version)[A/OL]. (2020-01-28)[2020-01-28].http://wsjkw.nx.gov.cn/info/1040/13360.htm. (in Chinese)
28	山东省卫生健康委员会.山东省新型冠状病毒感染的肺炎中医药诊疗方案[A].2020. Health Commission of Shandong Province. Treatment of novel coronavirus pneumonia in Shandong by traditional Chinese medicine[A]. 2020. (in Chinese)
29	陕西省卫生健康委员会.陕西省新型冠状病毒感染的肺炎中医药治疗方案(试行第一版)[A/OL].陕卫中医发〔2020〕4号.(2020-01-23)[2020-01-23].http://sxwjw.shaanxi.gov.cn/art/2020/1/23/art_10_67378.html. Health Commission of Shaanxi Province. Treatment of novel coronavirus pneumonia in Shaanxi by traditional Chinese medicine (trail version 1)[A/OL]. No.4〔2020〕of the Traditional Chinese Medicine Office of Health Commission of Shaanxi Province. (2020-01-23)[2020-01-23]. http://sxwjw.shaanxi.gov.cn/art/2020/1/23/art_10_67378.html. (in Chinese)
30	天津市卫生健康委员会.天津市新型冠状病毒感染的肺炎中医药防治方案(试行)[A/OL].(2020-01-27)[2020-01-27].http://wsjk.tj.gov.cn/art/2020/1/27/art_88_70210.html. Health Commission of Tianjin.Prevention and treatment of novel coronavirus pneumonia in Tianjin by traditional Chinese medicine (trail version)[A/OL]. (2020-01-27)[2020-01-27].http://wsjk.tj.gov.cn/art/2020/1/27/art_88_70210.html. (in Chinese)
31	西藏自治区藏医药管理局.西藏自治区新型冠状病毒感染的肺炎藏医药防治方案[A].藏藏医药发〔2020〕3号, 2020. Tibet Administration of Tibetan Medicine. Prevention and treatment of novel coronavirus pneumonia in Tibet by Tibetan medicine[A].No.3〔2020〕of the Tibet Administration of Tibetan Medicine, 2020. (in Chinese)
32	广东省中医药局.广东省新型冠状病毒感染的肺炎中医药治疗方案(试行第一版)[A/OL].粤中医办函〔2020〕19号.(2020-01-25)[2020-01-25].http://szyyj.gd.gov.cn/zwgk/gsgg/content/post_2879085.html. Traditional Chinese Medicine Bureau of Guangdong Province.Prevention and treatment of novel coronavirus pneumonia in Guangdong by traditional Chinese medicine (trail version 1)[A/OL]. No.19〔2020〕of the Traditional Chinese Medicine Bureau of Guangdong Province.(2020-01-25)[2020-01-25].http://szyyj.gd.gov.cn/zwgk/gsgg/content/post_2879085.html. (in Chinese)
33	辽宁省卫生健康委员会.辽宁省新型冠状病毒感染的肺炎中医药诊疗方案(试行第二版)[A/OL].(2020-02-03)[2020-02-03].http://wsjk.ln.gov.cn/gsga/202002/t20200203_3733243.html. Health Commission of Liaoning Province.Treatment of novel coronavirus pneumonia in Shandong by traditional Chinese medicine (trail version 2)[A/OL]. (2020-02-03)[2020-02-03].http://wsjk.ln.gov.cn/gsga/202002/t20200203_3733243.html. (in Chinese)
34	浙江省中医药管理局.新型冠状病毒感染的肺炎中医药防治推荐方案(试行第四版)[A/OL].浙中医药〔2020〕3号, 2020. Zhejiang Administration of Traditional Chinese Medicine.Recommended scheme for the prevention and treatment of novel coronavirus pneumonia by traditional Chinese medicine (trail version 4)[A/OL].No.3〔2020〕of the Zhejiang Administration of Traditional Chinese Medicine, 2020. (in Chinese)
35	海南省卫生健康委员会.海南省新型冠状病毒感染的肺炎中医药防治方案(试行第二版)[A/OL].琼卫中医函〔2020〕8号.(2020-02-03)[2020-02-03].http://wst.hainan.gov.cn/swjw/xxgk/0200/0202/202003/t20200305_2756525.html. Health Commission of Hainan Province.Prevention and treatment of novel coronavirus pneumonia in Hainan by traditional Chinese medicine (trail version 2)[A/OL].No.8〔2020〕of the Traditional Chinese Medicine Office of Health Commission of Hainan Province.(2020-02-03)[2020-02-03].http://wst.hainan.gov.cn/swjw/xxgk/0200/0202/202003/t20200305_2756525.html. (in Chinese)
36	新疆维吾尔自治区卫生健康委员会.新疆维吾尔自治区新型冠状病毒惑染的肺炎中医药防治方案[A/OL].(2020-01-30)[2020-01-30].http://www.xjhfpc.gov.cn/info/1986/17763.htm. Health Commission of Xinjiang Uygur Autonomous Region. Prevention and treatment of novel coronavirus pneumonia in Xinjiang by traditional Chinese medicine[A/OL].(2020-01-30)[2020-01-30]. http://www.xjhfpc.gov.cn/info/1986/17763.htm. (in Chinese)
37	内蒙古自治区卫生健康委员会.内蒙古自治区新型冠状病毒肺炎中医药诊疗方案(试行第二版)[A/OL].内卫办蒙中管理发〔2020〕15号.(2020-02-15)[2020-02-15].http://wjw.nmg.gov.cn/doc/2020/02/18/292482.shtml. Health Commission of Inner Mongolia. Treatment of novel coronavirus pneumonia in Inner Mongolia by traditional Chinese medicine (trail version 2)[A/OL]. No.15〔2020〕of the Traditional Chinese Medicine Office of Health Commission of Inner Mongolia. (2020-02-15)[2020-02-15] http://wjw.nmg.gov.cn/doc/2020/02/18/292482.shtml. (in Chinese)
38	武汉市新冠肺炎防控指挥部医疗救治组.关于在新型冠状病毒感染的肺炎中医药治疗中推荐使用中药协定方的通知[A].2020. Wuhan medical treatment group of novel coronavirus pneumonia. Notice on recommendation of the prescription of traditional Chinese medicine in the treatment of pneumonia caused by novel coronavirus[A].2020. (in Chinese)
39	夏文广, 安长青, 郑婵娟 et al. 中西医结合治疗新型冠状病毒肺炎34例临床研究[J]. 中医杂志, 2020, 61 (5): 375- 382 XIAWenguang , AN Changqing , ZHENG Chanjuan et al. Clinical observation on 34 patients with novel coronavirus pneumonia (COVID-19) treated with intergratedtraditional Chinese and western medicine[J]. Journal of Traditional Chinese Medicine, 2020, 61 (5): 375- 382 doi: 10.13288/j.11-2166/r.2020.05.002
40	刘清泉, 夏文广, 安长青 et al. 中西医结合治疗新型冠状病毒肺炎作用的思考[J]. 中医杂志, 2020, 61 (6): 463- 464 LIU Qingquan , XIA Wenguang , AN Changqing et al. Refection on Effects of Integrated Traditional Chinese and Western Medicine on Coronavirus Disease 2019(COVID-19)[J]. Journal of Traditional Chinese Medicine, 2020, 61 (6): 463- 464 doi: 10.13288/j.11-2166/r.2020.06.002
41	仝小林, 李修洋, 赵林华 et al. 从"寒湿疫"角度探讨新型冠状病毒肺炎(COVID-19)的中医药防治策略[J]. 中医杂志, 2020, 61 (6): 465- 470 TONG Xiaolin , LI Xiuyang , ZHAO Linhua et al. Discussion on traditional Chinese medicine prevention and treatment strategies of coronavirus disease 2019(COVID-19) from the perspective of"cold-dampness pestilence"[J]. Journal of Traditional Chinese Medicine, 2020, 61 (6): 465- 470 doi: 10.13288/j.11-2166/r.2020.06.003
42	陈永灿 . 简易名方临证备要[M]. 北京: 人民卫生出版社, 2016: 48- 55 CHEN Yongcan . Preparation for application of classic formulation[M]. Beijing: People's Medical Publishing House, 2016: 48- 55
43	宗阳, 丁美林, 贾可可 et al. 基于网络药理学和分子对接法探寻达原饮治疗新型冠状病毒肺炎(COVID-19)活性化合物的研究[J]. 中草药, 2020, 51 (4): 836- 844 ZONG Yang , DING Meilin , JIA Keke et al. Exploring active compounds of Da-Yuan-Yin in treatment of COVID-19 based on network pharmacology and molecular docking method[J]. Chinese Traditional and Herbal Drugs, 2020, 51 (4): 836- 844 doi: 10.7501/j.issn.0253-2670.2020.04.002
44	张玲, 梅波, 刘中洋 . 清热解毒类中药注射剂治疗呼吸系统感染的研究进展[J]. 中国医药, 2019, 14 (11): 1750- 1753 ZHANG Ling , MEI Bo , LIU Zhongyang . Research progress of antifebrile and detoxifying traditional Chinese medicine injection in treatment of respiratory infection[J]. China Medicine, 2019, 14 (11): 1750- 1753 doi: 10.3760/j.issn.1673-4777.2019.11.037
45	杨谦 . 凉膈散作用机制的研究进展[J]. 临床医药文献电子杂志, 2017, 4 (24): 4736- 4738 YANG Qian . Research progress on the mechanism of Liangge decoction[J]. Journal of Clinical Medical, 2017, 4 (24): 4736- 4738 doi: 10.16281/j.cnki.jocml.2017.24.149
46	张祺嘉钰, 孙毅, 张恩户 et al. 清瘟败毒饮治疗感染性疾病的实验及其临床研究[J]. 海峡药学, 2015, 27 (5): 99- 100 ZHANG Qijiayu , SUN Yi , ZHANG Enhu et al. Experimental and clinical study of Qingwen Baidu Decoction in the treatment of infectious diseases[J]. Strait Pharmaceutical Journal, 2015, 27 (5): 99- 100
47	吕睿冰, 王文菊, 李欣.中药连花清瘟治疗新型冠状病毒肺炎疑似病例63例临床观察[J/OL].中医杂志, http://kns.cnki.net/kcms/detail/11.2166.R.20200215.1633.004.html. LYU Ruibing, WANG Wenju, LI Xin. Novel coronavirus pneumonia suspected cases treated with Lianhua Qingwen: A clinical observation of 63 cases[J/OL]. Journal of Traditional Chinese Medicine, http://kns.cnki.net/kcms/detail/11.2166.R.20200215.1633.004.html. (in Chinese)

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