Please wait a minute...
浙江大学学报（医学版）
浙江大学学报（医学版）  1998, Vol. 27 Issue (4): 155-156    DOI: 10.3785/j.issn.1008-9292.1998.04.004
论著     
白血病患者血清酶活性初探
赵小英, 吴东, 王世泂
浙江医科大学附属第二医院内科
Serum Enzyme Activity in Patients with Leukemia
Zhao Xiaoying, Wu Dong, Wang Shijiong
Department of Internal Medicine, Second Affiliated Hospital, Zhejiang Medical University
 全文: PDF(167 KB)   HTML ( ) 
摘要： 目的:探讨不同类型白血病和不同病期白血病的血清酶活性变化,以及酶活性与外周血白细胞总数、白血病细胞数的关系。方法:采用酶联法测定75例白血病患者血清乳酸脱氢酶(LDH)、谷丙转氨酶(GPT)、碱性磷酸酶(AKP)活性,并与正常人组38例比较。结果:白血病组LDH、AKP活性明显高于正常人组,且急性淋巴细胞白血病(ALL)者的LDH活性与外周血白血病细胞数呈正相关(P<0.01);白血病完全缓解期(CR)患者LDH活性明显低于初发患者(P<0.01),血清GPT活性与正常人无显著性差异(P>0.05)。结论:动态观察血清LDH活性有助于白血病疗效的判断。
关键词： 急性淋巴细胞白血病/酶学;  急性非淋巴细胞白血病/酶学;  慢性淋巴细胞白血病/酶学;  慢性髓样白血病/酶学;  乳酸脱氢酶/血液;  丙氨酸转氨酶/血液;  碱性磷酸酶/血液    
Abstract: Objective: To study the activity of serum lactic dehydrogenase (LDH), alkaline phosphatase(AKP) and glutamicpyruvic transaminase (GPT) in patients with leukemia and normal persons, and to study the relationship enzyme activity to WBC counts and leukemic cell counts. Methods: Enzyme activity was measured by ELISA method. Results: Serum LDH and AKP activity was higher in patients with leukemia than that in normal controls. LDH activity in all patients showed positive correlation with leukemic cell counts in peripheral blood. LDH activity was lower in patients with CR than that in patients at the initial stage of the disease (P<0.01). There was no significant difference in GPT activity between patients and normal controls. Conclusion: Observation of the change of LDH activity in the course of treatment is helpful in judging the treatment response.
Key words: Leukemia, lymphocytic, acute/enzymol    Leukemia, nonlymphocytic, acute/enzymol    Leukemia, lymphocytic, chronic/enzymol    Leukemia, myeloid, chronic/enzymol    Lactate dehydrogenase/blood    Alanine aminotransferase/blood    Alkaline phosphatase/blood
收稿日期: 1997-09-15 出版日期: 1998-07-25
服务　　
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章　　
赵小英
吴东
王世泂

引用本文:

赵小英, 吴东, 王世泂. 白血病患者血清酶活性初探[J]. 浙江大学学报（医学版）, 1998, 27(4): 155-156.

Zhao Xiaoying, Wu Dong, Wang Shijiong. Serum Enzyme Activity in Patients with Leukemia. Journal of ZheJiang University(Medical Science), 1998, 27(4): 155-156.

链接本文:

https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1998.04.004    或    https://www.zjujournals.com/med/CN/Y1998/V27/I4/155

[1] 王炬峰 等. 高效抗逆转录病毒治疗对人类免疫缺陷病毒感染者骨代谢的影响[J]. 浙江大学学报（医学版）, 2016, 45(3): 228-235.
[2] 吴丽娟，靳昌忠，白石，梁勇，吴南屏. 合并病毒性肝炎HIV感染患儿接受高效抗逆转录酶病毒治疗后肝功能变化[J]. 浙江大学学报（医学版）, 2014, 43(2): 180-186.
[3] 毛小荣, 彭雪彬, 张有成, 李林平. 甘肃地区不同基因型丙肝感染与糖脂铁代谢异常的相关性研究[J]. 浙江大学学报（医学版）, 2013, 42(3): 345-349.
[4] 徐亚萍;俞惠民. 早产儿骨转化及早期补钙对骨转化的影响[J]. 浙江大学学报（医学版）, 2003, 32(5): 418-422.
[5] 钟步云, 杨荣伟, 吴建平, 施莉萍. 心脏术后心肌损伤生化标志物的动态变化及意义[J]. 浙江大学学报（医学版）, 1999, 28(5): 217-220.