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浙江大学学报（医学版）
浙江大学学报（医学版）  1998, Vol. 27 Issue (1): 6-8    DOI: 10.3785/j.issn.1008-9292.1998.01.002
论著     
克罗米芬对分泌期子宫内膜厚度和血雌孕激素的影响
陈丹青, 周馥贞
浙江医科大学附属妇产科医院
Effects of Clomiphene Citrate on the Thickness of Secretory-Phase Endometrium and Serum Hormonal Levels
Chen Danqing, Zhou Fuzhen
Affiliated Obstetrics and Gynecology Hospital, Zhejiang Medical University
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摘要： 目的:为探讨克罗米芬对分泌期子宫内膜厚度的影响。方法:应用阴道超声观测20例不孕妇女服用克罗米芬(实验组)和16例不孕妇女未服用克罗米芬(对照组)分泌期子宫内膜的厚度。并采用放射免疫法测定血清雌二醇(E2)和孕酮(P)浓度。结果:实验组排卵后11天血E2、P浓度显著高于对照组同期水平,分别为680.8±206.9pmol/L、52.7±13.6nmol/L和309.6±62.5pmol/L、35.6±12.4nmol/L.(P均2值显著低于对照组同期水平.分别为82.0±3.6和107.0±3.6(P<0.05)。子宫内膜厚度显著较对照组同期厚度为薄.分别为0.63±0.11cm和0.79±0.09cm(P<0.05)。相关性分析示:对照组血P浓度与子宫内膜厚度呈正相关,而实验组两者无相关性。结论:克罗米芬应用后血P/E2值下降.从而影响分泌期子宫内膜发育。
关键词： 克罗米芬/药理学;  雌二醇/血液;  黄体酮/血液;  子宫内膜/药物作用    
Abstract: Objective:To study the effects of clomiphene citrate(CC) on the thickness of secretory-phase endometrium. Method:Thirty six infertile cases with regular ovulation were included in the study. Amony them,20 cases treated with CC served as study group and another 16 cases without any treatment as control group. The thickness of endometrium on 11th day after ovulation was measured with vaginal ultrasonography and serum estrodiol (E2) and progesterone (P) were measured by RIA in the meantime. Results:Serum E2 and P levels in study group were significantly higher than those in control group(680.8±206.9 pmol/L vs 309.6±62.5 pmol/L, 52.7±13.6 nmol/L vs 35.6±12.4 nmol/L). However, the P/E2 level in study group was significantly lower than that in control group(82.0±3.6 vs 107.0±3.6), the thickness of endometrium in study group was also significantly thinner than that of endometrium in control group(0.63±0.11 cm vs 0.79±0.09 cm). There was a significant positive correlation between serum progesterone level and endometrium thickness in control group. But in study group there was no such correlation. Conclusion:CC may affect the development of secretory-phase endometrium through significant decrease of the P/E2 level in luteal phase.
Key words: Clomiphene/pharmacol    Estradiol/blood    Progesterone/blood    endometrium/drug eff
出版日期: 1998-01-25
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陈丹青
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引用本文:

陈丹青, 周馥贞. 克罗米芬对分泌期子宫内膜厚度和血雌孕激素的影响[J]. 浙江大学学报（医学版）, 1998, 27(1): 6-8.

Chen Danqing, Zhou Fuzhen. Effects of Clomiphene Citrate on the Thickness of Secretory-Phase Endometrium and Serum Hormonal Levels. Journal of ZheJiang University(Medical Science), 1998, 27(1): 6-8.

链接本文:

https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1998.01.002    或    https://www.zjujournals.com/med/CN/Y1998/V27/I1/6

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