作者研究了55例急性、迁延性和慢性腹泻患儿的粪α1-抗胰蛋白酶(α1-AT)含量,年龄1~29个月。结果显示,迁延性腹泻及慢性腹泻组每克湿粪α1-AT含量分别为0.49±0.29mg、0.68±0.32mg均显著大于正常组0.27±0.25mg(P分别<0.05,0.01);急性腹泻组为0.36±0.27mg,与正常组比较无显著增加,但显著低于慢性腹泻组(P<0.05)。我们测定的每克湿粪α1-AT正常值<0.52mg。提示随着腹泻病程延长粪α1-AT量增加,迁延性及慢性腹泻时血浆蛋白经肠道丢失增加,表明迁延性、慢性腹泻是一种蛋白质丢失性肠病,应引起重视。
Fecal α1-Antitrypsin(Fα1-AT)was analyzed from 55 children with acute,persistent or chronic diarrhea aged 1~29 months. The results showed that Fα1-AT in persistent(0.49±0.29 mg/g,wet stool,P<0.05) and chronic(0.68±0.32 mg/g wet stool, P<0.01) diarrhea,increased significantly as compared with that of the controls(0.27±0.25 mg/g wet stool). A nonsignificant increment of Fα1-AT was found in patients with acute diarrhea during comparison with the control group. The cases of chronic diarrhea showed higher Fα1-AT values than those of the acute patients(P<0.05). The normal Fα1-AT values we measured was below 0.52 mg/g wet stool.Persistent or chronic diarrhea led to excessive loss of plasma proteins through the intestinal tract.It has been noted that persistent or chronic diarrhea belongs to protein-losing enteropathy.
江米足, 许蓓, 叶瑞云. 婴幼儿腹泻时肠道蛋白质丢失的研究[J]. 浙江大学学报（医学版）, 1997, 26(1): 21-22.
Jiang Mizu, Xu Bei, Ye Ruiyun. ENTERIC LOSS OF PROTEIN IN CHILDREN WITH DIARRHEA. Journal of ZheJiang University(Medical Science), 1997, 26(1): 21-22.
https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1997.01.007 或 https://www.zjujournals.com/med/CN/Y1997/V26/I1/21
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