目的:研究超顺磁性氧化铁(superparamagnetic iron oxide,SPIO) 对周围质子的弛豫时间的影响,探讨不同颗粒、浓度SPIO的MR信号特征. 方法:对不同粒径及浓度的SPIO颗粒进行磁共振扫描,记录各个粒径和浓度的SPIO颗粒的MR T1、T2、T2~*值,评价其信号特征.结果:①不同粒径的SPIO颗粒T1值与浓度呈负相关线性关系;②当SPIO浓度较低时,随粒径减小T2和T2~*值则上升明显;当SPIO浓度较高时,随粒径减小上升渐趋缓慢;③lg(T2)与SPIO颗粒粒径和浓度之间存在线性依存关系.结论:SPIO颗粒对MR信号的影响以T1和T2效应为主;T2值可作为SPIO颗粒MR成像的主要检测指标;SPIO粒径大小、浓度和T2值三者之间存在着特定的线性关系.
Objective: To investigate the magnetic resonance (MR) signal features of superparamagnetic iron oxide (SPIO) with different partical size and concentration. Methods: The superparamagnetic iron oxide with different concentration and particle size was scanned by magnetic resonance; T1,T2 and T2~* values of each group were recorded to evaluate the features of MR signals. Results: The T1 value of SPIO with different particle size had negative linear relationship with concentration.In low concentration the T2 and T2~* values were elevated markedly with the particle size decreased; while in high concentration the T2 and T2~* values were elevated gently with particle size decreased.lg(T2),particle size and concentration of SPIO had linear relationship. Conclusions: SPIO affects magnetic resonance signal mainly with effect on T1 and T2.T2 value can be regarded as the major detection index in the magnetic resonance scan of SPIO.There is a linear relationship among particle size,SPIO concentration and lg(T2) value.
国家高技术研究发展计划(863计划)(2006AA02Z485);浙江省科学技术厅重大与高发疾病防治技术专项基金(2008C13027-2);国家自然科学基金(J20060714);浙江省医药卫生优秀青年科技人才专项科研基金(2009QN009);浙江省中医药青年课题(2007YB032)
林冰影，张景峰，张敏鸣. 不同粒径和浓度超顺磁性氧化铁MR信号特征的实验研究[J]. 浙江大学学报（医学版）, 2010, 39(2): 125-129.
https://www.zjujournals.com/med/CN/Y2010/V39/I2/125
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