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浙江大学学报(医学版)  2013, Vol. 42 Issue (2): 125-130    DOI: 10.3785/j.issn.1008-9292.2013.02.001
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病原菌耐药信号传导机制及多抗原肽疫苗研究进展与发展趋势
孙爱华1,方佳琪2,严杰2
1.浙江医学高等专科学校,浙江 杭州 310053;
2.浙江大学医学院病原生物学系,浙江 杭州 310058;
Advance and development in research of bacterial drug-resistance signaling mechanism and multiple antigenic peptide-based vaccines
SUN Ai-Hua1, FANG Jia-Qi2, YAN Jie2
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摘要:

细菌耐药性是当前人类面临的重大医学问题之一。接种疫苗是预防各种传染病最为经济和有效的措施,也是预防和控制耐药性病原菌感染相关传染病的有效途径。文中介绍了病原菌耐药相关信号传导机制及新型多抗原肽疫苗研究进展,并分析了其发展趋势,以供相关领域研究者参考。

关键词: 大肠杆菌沙门菌甲型副伤寒副结核分枝杆菌细菌菌苗肽类抗药性细菌药物耐受性病原菌耐药性疫苗    
收稿日期: 2012-12-28 出版日期: 2013-03-25
:  R 378  
基金资助:

浙江省自然科学基金资助项目(LY12H19002);浙江省医药卫生科学研究基金资助项目(2011KYB006).

通讯作者: 严杰(1956-),男,医学博士,教授,博导,主要从事病原菌致病机制及基因工程疫苗研究     E-mail: med_bp@zju.edu.cn
作者简介: 孙爱华(1968-),女,教授,主要从事病原菌致病与耐药机制及实验室诊断方法研究.
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引用本文:

孙爱华, 方佳琪, 严杰. 病原菌耐药信号传导机制及多抗原肽疫苗研究进展与发展趋势[J]. 浙江大学学报(医学版), 2013, 42(2): 125-130.

SUN Ai-Hua, FANG Jia-Qi, YAN Jie. Advance and development in research of bacterial drug-resistance signaling mechanism and multiple antigenic peptide-based vaccines. Journal of ZheJiang University(Medical Science), 2013, 42(2): 125-130.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2013.02.001        http://www.zjujournals.com/med/CN/Y2013/V42/I2/125

\[1\]SHAKHNOVICH E A,STURTEVANT D,MEKALANOS J J.Molecular mechanisms of virstatin resistance by non-O1/non-O139 strains of Vibrio cholerae \
[J\].Mol Microbiol,2007,66(6):1331-1341.
\
[2\]KAN B,WANG M,JING H,et al.Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms \
[J\].J Virol,2005,79(18):11892-11900.
\
[3\]GAMBOTTO A,BARRATT-BOYES S M,DE JONG M D,et al.Human infection with highly pathogenic H5N1 influenza virus \
[J\].Lancet,2008,371(9622):1464-1475.
\
[4\]HUANG Y T,TENG L J,HO S W,et al. Streptococcus suis infection \
[J\].J Microbiol Immunol Infect,2005,38(5):306-313.
\
[5\]MATHEMA B,KUREPINA N E,BIFANI P J,et al.Molecular epidemiology of tuberculosis: current insights \
[J\].Clin Microbiol Rev,2006,19(4):658-685.
\
[6\]WILDE H.Enteric fever due to Salmonella typhi and paratyphi A: A neglected and emerging problem \
[J\]. 2007,25(29):5246-5247.
\
[7\]CALORE E E,UIP D E,PEREZ N M.Pathology of the swine-origin influenza A(H1N1) flu \
[J\].Pathol Res Pract,2011,207(2):86-90.
\
[8\]SUN A H,FAN X L,LI L W,et al.Rapid detection of rpoB gene mutations in Rif-resistant M.tuberculosis isolates by oligonucleotide microarray \
[J\].Biomed Environ Sci,2009,22(3):253-258.
\
[9\]GUPTA S K,MEDALLA F,OMONDI M W,et al.Laboratory-based surveillance of paratyphoid fever in the United States: travel and antimicrobial resistance \
[J\].Clin Infect Dis,2008,46(11):1656-1663.
\
[10\]SMITH P A,ROMESBERG F E.Combating bacteria and drug resistance by inhibiting mechanisms of persistence and adaptation \
[J\].Nat Chem Biol,2007,3(9):549-556.
\
[11\]CASINO P,RUBIO V,MARINA A.The mechanism of signal transduction by two-component systems \
[J\].Curr Opin Struc Biol,2010,20(6):763-771.
\
[12\]READING N C,RASKO D A,TORRES A G,et al.The two-component system QseEF and the membrane protein QseG link adrenergic and stress sensing to bacterial pathogenesis \
[J\].Proc Natl Acad Sci USA,2009,106(14):5889-5894.
\
[13\]LOU Hongqiang,GE Yumei,ZHANG Jinliang,et al(楼宏强,葛玉梅,张金良,等).Role of fliY gene in pathogenicity-associated chemotaxis and colonization of Campylobacter jejuni \
[J\].Journal of Zhejiang University: Medical Sciences(浙江大学学报医学版),2013,42(2):141-148.(in Chinese)
\
[14\]WU Yifei,SUN Aihua,ZHAO Jinfang, et al(吴亦斐,孙爱华,赵金方,等).Distribution of bacterial drug inactive enzyme-encoding genes and expression-inducing and -inhibiting mechanism of the genes \
[J\].Journal of Zhejiang University: Medical Sciences(浙江大学学报医学版),2013,42(2):131-140.(in Chinese)
\
[15\]CABUSORA L,SUTTON E,FULMER A,et al.Differential network expression during drug and stress response \
[J\].Bioinformatics,2005,21(12):2898-2905.
\
[16\]PAPAVINASASUNDARAM K G,CHAN B,CHUNG J H,et al.Deletion of the Mycobacterium tuberculosis pknH gene confers a higher bacillary load during the chronic phase of infection in BALB/c mice \
[J\].J Bacteriol,2005,187(16):5751-5760.
\
[17\]ORTIZ de ORU -LUCANA D,ZOU P J,NIERHAUS M,et al.Identification of a novel two-component system SenS/SenR modulating the production of the catalase-peroxidase CpeB and the haem-binding protein HbpS in Streptomyces reticuli \
[J\].Microbiology,2005,151(11):3603-3614.
\
[18\]PARISH T,SMITH D A,ROBERTS G,et al.The senX3 regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence \
[J\].Microbiology,2003,149(6):1423-1435.
\
[19\]RICKMAN L,SALDANHA J W,HUNT D M,et al.A two-component signal transduction system with a PAS-domain containing sensor is required for virulence of Mycobacterium tuberculosis in mice \
[J\].Biochem Biophys Res Commun,2004,314(1):259-267.
\
[20\]SONG J H,JUNG S I,KO K S,et al.High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia \
[J\].Antimicrob Agents Chemother,2004,48(6):2101-2107.
\
[21\]CHESNEL L,CARAPITO R,CROIZ J, et al.Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance \
[J\].Antimicrob Agents Chemother,2005,49(7):2895-2902.
\
[22\]MASCHER T,HEINTZ M,Z HNER D,et al.The CiaRH system of Streptococcus pneumoniae prevents lysis during stress induced by treatment with cell wall inhibitors and by mutations in pbp2x involved in beta-lactam resistance \
[J\].J Bacteriol,2006,188(5):1959-1968.
\
[23\]DIAS R,F LIX D,CANICA M,et al.The highly conserved serine threonine kinase StkP of Streptococcus pneumoniae contributes to penicillin susceptibility independently from genes encoding penicillin-binding proteins \
[J\].BMC Microbiol,2009,9:121-129.
\
[24\]MURATA T,TSEBG W,GUINA T,et al.PhoPQ-mediated regulation produces a more robust permeability barrier in the outer membrane of Salmonella enterica serovar typhimurium \
[J\].J Bacteriol,2007,189(20):7213-7222.
\
[25\]WANG Zhejiong,XIA Xiaoping,LOU Hongqiang, et al(夏肖萍,楼宏强,孙爱华,等).Deletion of phoQ gene decreases the resistance of Pseudomonas aeruginosa to aminoglycoside antibiotics \
[J\].Chinese Journal of Microbiology and Immunology(中华微生物学和免疫学杂志),2009,29(9):801-806.(in Chinese)
\
[26\]EGUCHI Y,OSHIMA T,MORI H,et al.Transcriptional regulation of drug efflux genes by EvgAS,a two-component system in Escherichia coli  \
[J\].Microbiology,2003,149(10):2819-2828.
\
[27\]RUAN P,XIA XP,SUN D,et al.Recombinant SpaO and H1a as immunogens for protection of mice from lethal infection with Salmonella paratyphi A: Implications for rational design of typhoid fever vaccines \
[J\].Vaccine,2008,26(51):6639-6644.
\
[28\]ZHANG C L,WANG H,YAN J.Leptospirosis prevalence in Chinese populations in the last two decades \
[J\].Microbes Infect,2012,14(4):317-323.
\
[29\]LUO D J,XUE F,OJCIUS D M,et al.Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp.and characterization of their immunogenicity \
[J\].Vaccine,2010,28(1):243-255.
\
[30\]JOHNSON T R,VARGA S M,BRACIALE T J,et al.Vbeta14(+) T cells mediate the vaccine-enhanced disease induced by immunization with respiratory syncytial virus(RSV) G glycoprotein but not with formalin-inactivated RSV \
[J\].J Virol,2004,78(16):8753-8760.
\
[31\]YANG Z Y,WERNER H C,KONG W P,et al.Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses \
[J\].Proc Natl Acad Sci USA,2005,102(3):797-801.
\
[32\]NICHOLAS R A J,AYLING R D,MCAULIFFE L.Vaccines for Mycoplasma diseases in animals and man \
[J\].J Comp Path,2009,140(2-3):85-96.
\
[33\]BRUNHAM R C,REY-LADINO J.Immunology of Chlamydia infection: Implications for a Chlamydia trachomatis vaccine \
[J\].Immunology,2005,5(2):149-161.
\
[34\]MOZDZANOWSKA K.Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2 \
[J\].Vaccine,2003,21(19-20):2616-2626.
\
[35\]LIN X A,SUN A H,RUAN P,et al.Characterization of conserved combined T and B cell epitopes in Leptospira interrogans major outer membrane proteins OmpL1 and LipL41 \
[J\].BMC Microbiol,2011,11(1):21-26.
\
[36\]WANG Xuehai,MAO Yafei,YAN Jie(王学海,毛亚飞,严杰).Prediction of urease subunit B epitopes of Helicobacter pylori and epitope screening by phage display technique \
[J\].Chinese Journal of microbiology and Immunologu(中华微生物学和免疫学杂志),2007,27(5):432-437.(in Chinese)
\
[37\]LIN X A,ZHAO J F,YAN J.Identification of immunodominant B- and T-cell combined epitopes in outer membrane lipoprotein LipL32 and LipL21 of Leptospira interrogans \
[J\]. Clin Vaccine Immunol,2010,17(5):778-783.
\
[38\]WELSH R M,FUJINAMI R S.Pathogenic epitopes,heterologous immunity and vaccine design \
[J\].Nat Microbiology,2007,5(7):555-563.
\
[39\]YANG X.Role of cytokines in Chlamydia trachomatis protective immunity and immunopathology \
[J\].Curr Pharm Des,2003,9(1):67-73.
 
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