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浙江大学学报(医学版)  2013, Vol. 42 Issue (5): 481-485    DOI: 10.3785/j.issn.1008-9292.2013.05.001
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TcpC研究现状与展望
潘建平1,辛晓丽2
1.浙江大学城市学院医学院,浙江 杭州 310015;
2.浙江大学医学院基础医学系,浙江 杭州 310058;
Progress in TcpC research
PAN Jian-Ping1, XIN Xiao-Li2
1.Zhejiang University City College School of Medicine,Hangzhou 310015; 2.Department of Basic Medicine,Zhejiang University School of Medicine,Hangzhou 310058
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摘要:

TcpC是尿路致病性大肠埃希菌CFT073菌株分泌的一种Toll/interleukin-1 receptor(TIR)结构域类似物。它通过与髓样分化因子88结合,抑制Toll样受体信号途径介导的巨噬细胞活化和杀菌功能、从而逃逸机体免疫效应,利于大肠埃希菌在宿主体内的生存和繁殖,是大肠埃希菌重要的毒力因子,在肾盂肾炎等尿路感染发生中起重要作用。同时体内诱导β干扰素的TIR结构域衔接蛋白、干扰素调节因子3、以及白介素1β对TcpC发挥作用具有显著影响。本文介绍TcpC研究的现状和发展趋势。

关键词: 泌尿道感染肠致病性大肠杆菌Toll样受体肾盂肾炎    
Abstract:

TcpC is a homolog of the Toll/interleukin-1 receptor (TIR) domain and is secreted by uropathogenic E. coli strain CFT073. TcpC can bind to MyD88,hereby exerting inhibitory effects on macrophages. TcpC represents an important virulence factor that promotes bacterial survival and pathogenicity. TcpC plays a critical role in urinary tract infection,particularly in the pathogenesis of pyelonephritis. In this review,the progress and prospects in TcpC research are discussed.

Key words: Urinary tract infections    Enteropathogenic Escherichia coli    Toll-like receptors    Pyelonephritis
收稿日期: 2013-05-31 出版日期: 2013-09-25
:  R 378.2  
基金资助:

国家自然科学基金项目(30872325);浙江省医药卫生研究计划(2013KYA149)

作者简介: 潘建平(1962-),男,博士,教授,博士生导师,从事免疫学研究
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引用本文:

潘建平, 辛晓丽. TcpC研究现状与展望[J]. 浙江大学学报(医学版), 2013, 42(5): 481-485.

PAN Jian-Ping, XIN Xiao-Li. Progress in TcpC research. Journal of ZheJiang University(Medical Science), 2013, 42(5): 481-485.

链接本文:

https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2013.05.001        https://www.zjujournals.com/med/CN/Y2013/V42/I5/481

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