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浙江大学学报（医学版）
浙江大学学报（医学版）  2020, Vol. 49 Issue (1): 113-117    DOI: 10.3785/j.issn.1008-9292.2020.02.12
综述     
INK4基因座中反义非编码RNA调控细胞增殖与凋亡影响动脉粥样硬化的研究进展
方娟(),潘志成,郭晓纲*()
浙江大学医学院附属第一医院心血管内科, 浙江 杭州 310003
Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis
FANG Juan(),PAN Zhicheng,GUO Xiaogang*()
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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摘要：

动脉粥样硬化是冠心病的重要病理基础，INK4基因座中反义非编码RNA（ANRIL）位于与其相关性最强的遗传易感区段，即9号染色体短臂2区1带（Chr9p21）。ANRIL通过不同的转录剪接方式可产生线性、环状等多种转录本，可调控斑块内相关细胞的增殖和凋亡，与动脉粥样硬化斑块发生发展密切相关。线性ARNIL可通过调节染色质修饰过程调控斑块内血管平滑肌细胞增殖，也可从转录水平调控斑块内巨噬细胞增殖和凋亡；环状ANRIL可调控染色质修饰及干预核糖体RNA加工成熟，进而影响平滑肌细胞的增殖和凋亡。本文对ANRIL的进化特征、转录本的形成及结构、各转录本调节血管细胞增殖和凋亡进而参与动脉粥样硬化的机制进行了系统阐述，以期为深入理解动脉粥样硬化的发病机制，寻找动脉粥样硬化诊治靶点提供依据。
关键词： 动脉粥样硬化;  INK4基因座中反义非编码RNA;  细胞增殖;  细胞凋亡;  综述    
Abstract:

Atherosclerosis is an important pathological basis for coronary artery disease. ANRIL is an antisense non-coding RNA located in Chr9p21 locus, which was identified as the most significant risk locus associated with atherosclerosis. ANRIL can produce multiple transcripts including linear and circular transcripts after various transcript splicing. It has been illustrated that ANRIL plays important roles in the pathology of atherosclerosis by regulating the proliferation and apoptosis of vascular cells. Linear ANRIL can regulate the proliferation of vascular smooth muscle cells (VSMCs) in plaques by chromatin modification, as well as influence the proliferation and the apoptosis of macrophages in post transcription; circular ANRIL can affect the proliferation and apoptosis of VSMCs by chromatin modification as well as interfering with rRNA maturation. In this review, we describe the ANRIL evolution, different transcripts characteristics, and their roles in the proliferation and apoptosis of vascular cells to participate in the process of atherosclerosis, for further understanding the pathogenesis of atherosclerosis and finding potential targets for diagnosis and treatment of atherosclerosis.
Key words: Atherosclerosis    Antisense non-coding RNA in the INK4 locus    Cell proliferation    Apoptosis    Review
收稿日期: 2019-12-02 出版日期: 2020-06-08
CLC:  R543.5  
基金资助: 国家卫生计生委科学研究基金-浙江省医药卫生重大科技计划（省部共建项目）(WKJ-ZJ-819);浙江省属高校基本科研业务费专项资金资助(2019XZZX003-15);浙江省重点研发计划(2020C03017)
通讯作者: 郭晓纲     E-mail: fangjuan@zju.edu.cn;gxg22222@zju.edu.cn
作者简介: 方娟(1994-), 女, 硕士, 主要从事动脉粥样硬化基础机制与临床治疗研究; E-mail:fangjuan@zju.edu.cn; https://orcid.org/0000-0002-0900-3844
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引用本文:

方娟,潘志成,郭晓纲. INK4基因座中反义非编码RNA调控细胞增殖与凋亡影响动脉粥样硬化的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 113-117.

FANG Juan,PAN Zhicheng,GUO Xiaogang. Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis. J Zhejiang Univ (Med Sci), 2020, 49(1): 113-117.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.02.12    或    http://www.zjujournals.com/med/CN/Y2020/V49/I1/113

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