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浙江大学学报（医学版）
浙江大学学报（医学版）  1998, Vol. 27 Issue (1): 1-5    DOI: 10.3785/j.issn.1008-9292.1998.01.001
论著     
阿霉素的新示波极谱研究
朱亚尔, 周雪枫, 孙缨
浙江医科大学药物分析学教研室
Study of 1.5th Order Differential Polarography of Adriamycin
Zhu Ya'er, Zhou Xuefeng, Sun Ying
Department of Pharmacy, Zhejiang Medical University
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摘要： 目的:为快速、准确测定生物样品中阿霉素的含量.探讨其反应机理。方法:采用新示波极谱法研究阿霉素在Britton-Robinson(PH=4.1)介质中的1.5次微分极谱行为,并通过循环伏安法、常规脉冲极谱法、经典极谱法等.对阿霉素的电极反应机理作了详细探讨。结果:发现该法所得还原峰为一双电子、单质子的不可逆电极过程.在选定的最佳测试条件下.于-0.45V(vs.SCE)左右处得一还原峰.其浓度在9.50×10-8~2.50×10-5g/ml范围内呈良好的线性,其线性方程为Y=3.96×105X-0.021,相关系数为0.9992,回收率在88.0%~115.0%之间。结论:该法用于生物样品中痕量阿霉素的测定.方法灵敏、稳定,结果较满意。
关键词： 阿霉素/分析;  1.5次微分极谱法;  极谱法    
Abstract: Objective:For quickly and accurately determination the concentration of adriamycin (ADM) in plasmaand urine, and discussion the mechanism of electrode process. Methods:1.5 th order differential polarogra phy behavior of ADM was studied, ADM also has been investigated by cyclic voltammetry. pulse polargraphic,etc. Results:It has been found that electrode process is an irreversible two-electron,one-proton process. In the opctimal condition.a sensitive reduction peak of ADM was obtained at -0.45 V(vs.SCE). The linear concentration range was found to occur from 9.50×10-8g/ml to 2.50×10-5g/ml,r=0.9992,the recovery rate of ADM was between 88.0 and 115.0%. Conclusion:The methods was sensitive and satisfactory for the determination of trace ADM in urine and blood sample.
Key words: Adriamycin/anai    1.5th order differential polarography    Polarography
出版日期: 1998-01-25
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朱亚尔
周雪枫
孙缨

引用本文:

朱亚尔, 周雪枫, 孙缨. 阿霉素的新示波极谱研究[J]. 浙江大学学报（医学版）, 1998, 27(1): 1-5.

Zhu Ya'er, Zhou Xuefeng, Sun Ying. Study of 1.5th Order Differential Polarography of Adriamycin. Journal of ZheJiang University(Medical Science), 1998, 27(1): 1-5.

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https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1998.01.001    或    https://www.zjujournals.com/med/CN/Y1998/V27/I1/1

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