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浙江大学学报（医学版）
浙江大学学报（医学版）  1996, Vol. 25 Issue (5): 201-203    DOI: 10.3785/j.issn.1008-9292.1996.05.004
论著     
细胞色素P-450亚族选择性底物的合成
宣贵达, 陈建
浙江医科大学医用化学教研室
SYNTHESIS OF SELECTIVE SUBSTRATE OF CYTOCHROME P-450 SUBFAMILY
Xuan Guida and Chen Jian
Department of Medical Chemistry, Zhejiang Medical University
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摘要：

为了便于国内同行对细胞色素P-450(以下简称P-450)亚族的深入研究,作者合成了P450ⅠA和ⅡB亚族的选择性底物乙氧基异酚 唑和戊氧基异酚 唑,并对合成品与国外标准产品的结构和酶学表征进行了比较。结果表明:合成品无论从结构上还是从酶学表征上均与国外产品基本一致。因此,在P-450研究中可用本合成品替代国外产品。
关键词： 乙氧基异酚 唑/化学合成;  戊氧基异酚 唑/化学合成;  细胞色素P-450类;  选择性底物;  底物特异性    
Abstract:

Ethoxyresorufin and pentoxyresorufin, the selective substrates of Cytochrome P-450 Ⅰ A and Ⅱ B isozymes have been successfully synthesized,and their physical and chemical characteristics,NMR spectrum and the validity in measurement of P-450 enzyme activity were compared with those of the standards. The results showed no difference between these two products and the standards. Therefore,our products can be used as selective substrates in P-450 studies.
Key words: Ethoxyresorufin/chem syn    Pentoxyresorufin/chem syn    Cytochrome P-450    Selective substrate    Substrate specificity
收稿日期: 1995-12-27 出版日期: 1996-09-25
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引用本文:

宣贵达, 陈建. 细胞色素P-450亚族选择性底物的合成[J]. 浙江大学学报（医学版）, 1996, 25(5): 201-203.

Xuan Guida and Chen Jian. SYNTHESIS OF SELECTIVE SUBSTRATE OF CYTOCHROME P-450 SUBFAMILY. Journal of ZheJiang University(Medical Science), 1996, 25(5): 201-203.

链接本文:

https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1996.05.004    或    https://www.zjujournals.com/med/CN/Y1996/V25/I5/201

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[2] 傅旭春, 刘志强. 一组碳氢化合物与细胞色素P-450自旋状态的定量构效关系[J]. 浙江大学学报（医学版）, 1994, 23(2): 54-56.
[3] 傅旭春, 刘志强. 取代苯胺形成P-450-MI络合物构效关系的MINDO/3法研究[J]. 浙江大学学报（医学版）, 1993, 22(1): 16-18.