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浙江大学学报（医学版）
浙江大学学报（医学版）  2020, Vol. 49 Issue (6): 779-784    DOI: 10.3785/j.issn.1008-9292.2020.12.14
综述     
基于脂质组学的子宫内膜异位症生物标志物研究进展
林翠翠1(),陈正云2,王春艳1,席咏梅1,2,*()
1. 浙江大学遗传学研究所, 浙江 杭州 310058
2. 浙江大学医学院附属妇产科医院, 浙江 杭州 310006
Research progress on biomarkers for endometriosis based on lipidomics
LIN Cuicui1(),CHEN Zhengyun2,WANG Chunyan1,XI Yongmei1,2,*()
1. Institute of Genetics, Zhejiang University School of Medicine, Hangzhou 310058, China
2. Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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摘要：

子宫内膜异位症的发病机制不明，缺乏有效的生物标志物，疾病的延误诊断非常突出。脂质组学技术为子宫内膜异位症的诊断和预测提供了新的途径。外周血、子宫内膜液、腹腔液和卵泡液的鞘磷脂、磷脂酰胆碱和磷脂酰丝氨酸等对子宫内膜异位症及疾病分型具有良好的诊断价值；在位子宫内膜的磷脂酰胆碱、磷脂酰丝氨酸联合磷脂酸有望成为早期子宫内膜异位症的生物标志物；外周血的脂代谢数据对预测子宫内膜异位症相关不孕也有重要价值。脂质组学技术的发展将进一步推进子宫内膜异位症相关发病机制、疾病预测、诊断和治疗等方面的研究进展。
关键词： 子宫内膜异位症;  脂质组学;  生物标志物;  综述    
Abstract:

The pathogenesis of endometriosis is not well understood at the moment, and the lack of effective biomarkers often leads to delayed diagnosis of the disease. Lipidomics provides a new approach for the diagnosis and prediction of endometriosis. Sphingomyelin, phosphatidylcholine and phosphatidylserine in peripheral blood, endometrial fluid, peritoneal fluid and follicular fluid have good diagnostic value for endometriosis and disease classification; the lipid metabolites in the eutopic endometrium tissue are expected to be biomarkers of early endometriosis; and the lipid metabolites in peripheral blood are also of great value for predicting endometriosis-related infertility. The development of lipidomics technique will further advance the progress on the pathogenesis, prediction, diagnosis and treatment of endometriosis.
Key words: Endometriosis    Lipidomics    Biomarker    Review
收稿日期: 2020-08-17 出版日期: 2021-01-14
CLC:  R711.71  
基金资助: 浙江省基础公益研究计划(LGF20H040010)
通讯作者: 席咏梅     E-mail: 21718648@zju.edu.cn;xyyongm@zju.edu.cn
作者简介: 林翠翠(1993-), 女, 硕士研究生, 主要从事遗传学研究; E-mail:21718648@zju.edu.cn; https://orcid.org/0000-0002-5510-4486
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引用本文:

林翠翠,陈正云,王春艳,席咏梅. 基于脂质组学的子宫内膜异位症生物标志物研究进展[J]. 浙江大学学报（医学版）, 2020, 49(6): 779-784.

LIN Cuicui,CHEN Zhengyun,WANG Chunyan,XI Yongmei. Research progress on biomarkers for endometriosis based on lipidomics. J Zhejiang Univ (Med Sci), 2020, 49(6): 779-784.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.12.14    或    http://www.zjujournals.com/med/CN/Y2020/V49/I6/779

1 SIMOENS S , DUNSELMAN G , DIRKSEN C et al. The burden of endometriosis: costs and quality of life of women with endometriosis and treated in referral centres[J]. Hum Reprod, 2012, 27 (5): 1292- 1299
doi: 10.1093/humrep/des073
2 Revised American Society for Reproductive Medicine classification of endometriosis: 1996[J]. Fertil Steril, 1997, 67(5): 817-821. DOI: 10.1016/s0015-0282(97)81391-x.
3 WANG L , ZHENG W , MU L et al. Identifying biomarkers of endometriosis using serum protein fingerprinting and artificial neural networks[J]. Int J Gynaecol Obstet, 2008, 101 (3): 253- 258
doi: 10.1016/j.ijgo.2008.01.018
4 VIGANò P , SOMIGLIANA E , PANINA P et al. Principles of phenomics in endometriosis[J]. Hum Reprod Update, 2012, 18 (3): 248- 259
doi: 10.1093/humupd/dms001
5 CROOK D , HOWELL R , SIDHU M et al. Elevated serum lipoprotein(a) levels in young women with endometriosis[J]. Metabolism, 1997, 46 (7): 735- 739
doi: 10.1016/s0026-0495(97)90115-3
6 MELO A S , ROSA-E-SILVA J C , ROSA-E-SILVA A C et al. Unfavorable lipid profile in women with endometriosis[J]. Fertil Steril, 2010, 93 (7): 2433- 2436
doi: 10.1016/j.fertnstert.2009.08.043
7 HARZIF A K , SILVIA M , MARIANA A et al. Extrapelvic endometriosis in abdominal wall scar and PPAR gamma expression: a case report[J]. Int J Surg Case Rep, 2018, 53:66- 69
doi: 10.1016/j.ijscr.2018.10.026
8 KATAOKA H , MORI T , OKIMURA H et al. Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis[J]. Hum Reprod, 2019, 34 (6): 1019- 1029
doi: 10.1093/humrep/dez067
9 BROSENS J J , WILSON M S , LAM E W . FOXO transcription factors: from cell fate decisions to regulation of human female reproduction[J]. Adv Exp Med Biol, 2009, 665:227- 241
doi: 10.1007/978-1-4419-1599-3_17
10 YOO J Y , KIM T H , FAZLEABAS A T et al. KRAS activation and over-expression of SIRT1/BCL6 contributes to the pathogenesis of endometriosis and progesterone resistance[J]. Sci Rep, 2017, 7 (1): 6765
doi: 10.1038/s41598-017-04577-w
11 WANG J , WANG C , HAN X . Tutorial on lipidomics[J]. Anal Chim Acta, 2019, 1061:28- 41
doi: 10.1016/j.aca.2019.01.043
12 谢宏宇, 王文杰, 李贞子 et al. 卵巢癌脂质组学诊断标志物的筛选及其效果研究[J]. 中华肿瘤防治杂志, 2016, 23 (23): 1550- 1555
XIE Hongyu , WANG Wenjie , LI Zhenzi et al. Screening of lipid omics diagnostic markers for ovarian cancer and its effect study[J]. Chinese Journal of Cancer Prevention and Treatment, 2016, 23 (23): 1550- 1555
doi: 10.16073/j.cnki.cjcpt.2016.23.006
13 张逸人, 李晓静, 刘睿杰 . 脂质组学在糖尿病及其并发症早期诊断和治疗中的作用[J]. 中国油脂, 2018, 43 (11): 110- 115
ZHANG Yiren , LI Xiaojing , LIU Ruijie . The role of lipidomics in early diagnosis and treatment of diabetes mellitus and its complications[J]. China Oils and Fats, 2018, 43 (11): 110- 115
doi: 10.3969/j.issn.1003-7969.2018.11.023
14 曹正, 董莹, 赵晟隆 et al. 非靶向脂质组学在子痫前期预测中的应用[J]. 检验医学, 2020, 35 (2): 100- 107
CAO Zheng , DONG Ying , ZHAO Shenglong et al. Application of untargeted lipid omics in the prediction of preeclampsia[J]. Laboratory Medicine, 2020, 35 (2): 100- 107
doi: 10.3969/j.issn.1673-8640.2020.02.002
15 VOUK K , HEVIR N , RIBI?-PUCELJ M et al. Discovery of phosphatidylcholines and sphingomyelins as biomarkers for ovarian endometriosis[J]. Hum Reprod, 2012, 27 (10): 2955- 2965
doi: 10.1093/humrep/des152
16 D'ANGELO G , MOORTHI S , LUBERTO C . Role and function of sphingomyelin biosynthesis in the development of cancer[J]. Adv Cancer Res, 2018, 140:61- 96
doi: 10.1016/bs.acr.2018.04.009
17 BRAGA D , MONTANI D A , SETTI A S et al. Metabolomic profile as a noninvasive adjunct tool for the diagnosis of grades Ⅲ and Ⅳ endometriosis-related infertility[J]. Mol Reprod Dev, 2019, 86 (8): 1044- 1052
doi: 10.1002/mrd.23221
18 BOJIC L A , SAWYEZ C G , TELFORD D E et al. Activation of peroxisome proliferator-activated receptor δ inhibits human macrophage foam cell formation and the inflammatory response induced by very low-density lipoprotein[J]. Arterioscler Thromb Vasc Biol, 2012, 32 (12): 2919- 2928
doi: 10.1161/atvbaha.112.255208
19 AMETZAZURRA A , MATORRAS R , GARCíA-VELASCO J A et al. Endometrial fluid is a specific and non-invasive biological sample for protein biomarker identification in endometriosis[J]. Hum Reprod, 2009, 24 (4): 954- 965
doi: 10.1093/humrep/den450
20 DOMíNGUEZ F , FERRANDO M , DíAZ-GIMENO P et al. Lipidomic profiling of endometrial fluid in women with ovarian endometriosis[J]. Biol Reprod, 2017, 96 (4): 772- 779
doi: 10.1093/biolre/iox014
21 LI J , GAO Y , GUAN L et al. Discovery of phosphatidic acid, phosphatidylcholine, and phosphatidylserine as biomarkers for early diagnosis of endometriosis[J]. Front Physiol, 2018, 9:14
doi: 10.3389/fphys.2018.00014
22 NAGATA S , SUZUKI J , SEGAWA K et al. Exposure of phosphatidylserine on the cell surface[J]. Cell Death Differ, 2016, 23 (6): 952- 961
doi: 10.1038/cdd.2016.7
23 WANG X , DEVAIAH S P , ZHANG W et al. Signaling functions of phosphatidic acid[J]. Prog Lipid Res, 2006, 45 (3): 250- 278
doi: 10.1016/j.plipres.2006.01.005
24 CHAGOVETS V V , WANG Z , KONONIKHIN A S et al. Endometriosis foci differentiation by rapid lipid profiling using tissue spray ionization and high resolution mass spectrometry[J]. Sci Rep, 2017, 7 (1): 2546
doi: 10.1038/s41598-017-02708-x
25 ADAMYAN L V , STARODUBTSEVA N , BORISOVA A et al. Direct mass spectrometry differentiation of ectopic and eutopic endometrium in patients with endometriosis[J]. J Minim Invasive Gynecol, 2018, 25 (3): 426- 433
doi: 10.1016/j.jmig.2017.08.658
26 J?RGENSEN H , HILL A S , BESTE M T et al. Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility[J]. Fertil Steril, 2017, 107 (5): 1191- 1199.e2
doi: 10.1016/j.fertnstert.2017.03.013
27 POLAK G , BARCZY?SKI B , WERTEL I et al. Disrupted iron metabolism in peritoneal fluid may induce oxidative stress in the peritoneal cavity of women with endometriosis[J]. Ann Agric Environ Med, 2018, 25 (4): 587- 592
doi: 10.26444/aaem/75802
28 VOUK K , RIBI?-PUCELJ M , ADAMSKI J et al. Altered levels of acylcarnitines, phosphatidylcholines, and sphingomyelins in peritoneal fluid from ovarian endometriosis patients[J]. J Steroid Biochem Mol Biol, 2016, 159:60- 69
doi: 10.1016/j.jsbmb.2016.02.023
29 YU Z , ZHAI G , SINGMANN P et al. Human serum metabolic profiles are age dependent[J]. Aging Cell, 2012, 11 (6): 960- 967
doi: 10.1111/j.1474-9726.2012.00865.x
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