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浙江大学学报（医学版）
浙江大学学报（医学版）  2020, Vol. 49 Issue (5): 629-636    DOI: 10.3785/j.issn.1008-9292.2020.10.13
综述     
降血糖药对内皮祖细胞作用的研究进展
韩雪1,2(),蒋国军2,石巧娟1,*()
1. 杭州医学院实验动物中心, 浙江 杭州 310015
2. 浙江萧山医院药剂科, 浙江 杭州 311200
Effects of antihyperglycemics on endothelial progenitor cells
HAN Xue1,2(),JIANG Guojun2,SHI Qiaojuan1,*()
1. Laboratory Animal Center, Hangzhou Medical College, Hangzhou 310015, China
2. Department of Pharmacy, Zhejiang Xiaoshan Hospital, Hangzhou 311200, China
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摘要：

内皮祖细胞（EPC）在糖尿病血管并发症中发挥重要作用。大量研究证明，临床部分降血糖药可通过调节EPC功能进而发挥改善糖尿病并发症的作用。其中二甲双胍可通过多效性调节机体氧化应激水平或AMP活化蛋白激酶下游信号通路改善糖尿病患者的EPC功能；吡格列酮可通过调节端粒酶活性延缓EPC衰老；阿卡波糖、西格列汀和胰岛素在临床研究中均显示出提高EPC活性的作用，其机制主要表现为促进EPC增殖、迁移、黏附等。降血糖药的这种降血糖之外的药理作用可能是改善糖尿病并发症的机制之一。本文在分析EPC对糖尿病并发症血管修复影响的基础上，对降血糖药调控EPC数量和功能的研究进展作一综述。
关键词： 糖尿病;  内皮祖细胞;  降血糖药;  氧化应激;  端粒酶;  综述    
Abstract:

Endothelial progenitor cells (EPCs) play an important role in diabetic vascular complications. A large number of studies have revealed that some clinical antihyperglycemics can improve the complications of diabetes by regulating the function of EPCs. Metformin can improve EPCs function in diabetic patients by regulating oxidative stress level or downstream signaling pathway of adenosine monophosphate activated protein kinase; Pioglitazone can delay the aging of EPCs by regulating telomerase activity; acarbose, sitagliptin and insulin can promote the proliferation, migration and adhesion of EPCs. In addition to lowering blood glucose, the effects of antihyperglycemics on EPCs may also be one of the mechanisms to improve the complications of diabetes. This article reviews the research progress on the regulation of EPC proliferation and function by antihyperglycemics.
Key words: Diabetes mellitus    Endothelial progenitor cells    Antihyperglycemics    Oxidative stress    Telomerase    Review
收稿日期: 2020-04-25 出版日期: 2020-11-19
:  R587.1  
基金资助: 国家自然科学基金(31900381)
通讯作者: 石巧娟     E-mail: 13819113623@163.com;shiqiaojuan@163.com
作者简介: 韩雪(1988-), 女, 硕士, 助理研究员, 主要从事心脑血管疾病的内皮祖细胞机制研究; E-mail:13819113623@163.com; https://orcid.org/0000-0002-7849-0228
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引用本文:

韩雪,蒋国军,石巧娟. 降血糖药对内皮祖细胞作用的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(5): 629-636.

HAN Xue,JIANG Guojun,SHI Qiaojuan. Effects of antihyperglycemics on endothelial progenitor cells. J Zhejiang Univ (Med Sci), 2020, 49(5): 629-636.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.10.13    或    http://www.zjujournals.com/med/CN/Y2020/V49/I5/629

来源 细胞表面标志物 参考文献序号
外周血 CD31、酪氨酸激酶受体2、胎肝激酶1 5-6
骨髓 血管内皮生长因子受体2、CD31, 血管上皮钙黏素、血管性血友病因子 7
胚胎 内皮型一氧化氮合酶、血管内皮生长因子、胎肝激酶1、样酪氨酸激酶、血管上皮钙黏素、CD34、血小板内皮细胞黏附分子1 8-9
脐带血 标记乙酰化低密度脂蛋白、人源血管内皮生长因子受体2(KDR)、血管上皮钙黏素、CD31、血管性血友病因子、CD45 10
人脐静脉内皮细胞 CD133、CD146单克隆抗体(P1H12)、血管内皮生长因子受体2、血小板内皮细胞黏附分子、内皮联蛋白、细胞间黏附分子1 11
表 1  不同来源内皮祖细胞(EPC)的表面标志物
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