2019冠状病毒病(COVID-19)疑似患者合并焦虑和抑郁的临床分析

doi:10.3785/j.issn.1008-9292.2020.03.02

浙江大学学报（医学版）

2020, Vol. 49

Issue (2): 203-208 DOI: 10.3785/j.issn.1008-9292.2020.03.02

原著

2019冠状病毒病(COVID-19)疑似患者合并焦虑和抑郁的临床分析

李鑫¹(

),代甜²,王虹^1,*(

),石军年¹,袁薇¹,栗静¹,陈利军¹,张天明¹,张珊珊¹,孔焱¹,岳宁¹,时慧¹,何玉苹¹,胡惠芳¹,柳芙蓉¹,杨彩霞¹

1. 兰州大学第二医院发热隔离病房, 甘肃兰州 730030
2. 兰州大学公共卫生学院, 甘肃兰州 730000

Clinical analysis of suspected COVID-19 patients with anxiety and depression

LI Xin¹(

),DAI Tian²,WANG Hong^1,*(

),SHI Junnian¹,YUAN Wei¹,LI Jing¹,CHEN Lijun¹,ZHANG Tianming¹,ZHANG Shanshan¹,KONG Yan¹,YUE Ning¹,SHI Hui¹,HE Yuping¹,HU Huifang¹,LIU Furong¹,YANG Caixia¹

1. Fever Isolation Ward, Lanzhou University Second Hospital, Lanzhou 730030, China
2. School of Public Health, Lanzhou University, Lanzhou 730000, China

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摘要：

目的: 分析2019冠状病毒病（COVID-19）疑似患者伴发焦虑、抑郁的危险因素以便早期干预以改善临床预后。方法: 收集2020年1月31日至2月22日兰州大学第二医院发热隔离病房收治的COVID-19疑似患者76例，收集其临床资料并采用汉密尔顿焦虑量表评测患者焦虑情况，汉密尔顿抑郁量表评测患者抑郁情况，行多因素Logistic回归分析COVID-19疑似患者出现焦虑或抑郁的危险因素。结果: 女性患者较男性患者更易伴发焦虑（OR=3.206，95%CI：1.073~9.583，P < 0.05）和抑郁情绪（OR=9.111，95%CI：2.143~38.729，P < 0.01）；患者存在已知疫区及疫区人员接触史更容易伴发抑郁情绪（OR=3.267，95%CI：1.082~9.597，P < 0.05）。结论: 在COVID-19疑似患者隔离治疗期间，对于存在已知疫区及疫区人员接触史的女性患者应该早期进行心理干预，必要时提早给予药物治疗，以改善患者预后。

关键词： 2019冠状病毒病; 严重急性呼吸综合征冠状病毒2; 新型冠状病毒肺炎; 焦虑; 抑郁; Logistic模型

Abstract:

Objective: To explore the risk factors of anxiety and depression in patients with suspected coronavirus disease 2019 (COVID-19) so as to achieve early intervention and better clinical prognosis. Methods: Seventy-six patients with suspected COVID-19 in fever isolation wards of Second Hospital of Lanzhou University were enrolled From January 31, 2020 to February 22, 2020. Their clinical baseline data were collected. The anxiety of patients was assessed by Hamilton Anxiety Scale, and the depression of patients was assessed by Hamilton Depression Scale. Multivariate Logistic regression analysis was performed to explore the risk factors of anxiety and depression in these patients. Results: Female patients are more likely to have anxiety (OR=3.206, 95%CI:1.073-9.583, P < 0.05) and depression (OR=9.111, 95%CI:2.143-38.729, P < 0.01) than male patients; patients with known contact history of epidemic area and personnel in epidemic area are more likely to have depression (OR=3.267, 95%CI:1.082-9.597, P < 0.05). Conclusion: During the isolation treatment of suspected COVID-19 patients, early psychological intervention should be carried out for the female patients with known contact history of epidemic area and personnel in epidemic area, and drug treatment should be given in advance if necessary.

Key words: Coronavirus disease 2019 Severe acute respiratory syndrome coronavirus 2 Novel coronavirus pneumonia Anxiety Depression Logistic models

收稿日期: 2020-02-27 出版日期: 2020-03-06

R749.2

通讯作者: 王虹 E-mail: xin830910@163.com;1311098171@qq.com

作者简介: 李鑫(1983-), 男, 硕士, 副主任医师, 主要从事神经心理及脑血管病研究; E-mail:xin830910@163.com; https://orcid.org/0000-0001-7630-0163

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	李鑫
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	石军年
	袁薇
	栗静
	陈利军
	张天明
	张珊珊
	孔焱
	岳宁
	时慧
	何玉苹
	胡惠芳
	柳芙蓉
	杨彩霞

引用本文:

李鑫,代甜,王虹,石军年,袁薇,栗静,陈利军,张天明,张珊珊,孔焱,岳宁,时慧,何玉苹,胡惠芳,柳芙蓉,杨彩霞. 2019冠状病毒病(COVID-19)疑似患者合并焦虑和抑郁的临床分析[J]. 浙江大学学报（医学版）, 2020, 49(2): 203-208.

LI Xin,DAI Tian,WANG Hong,SHI Junnian,YUAN Wei,LI Jing,CHEN Lijun,ZHANG Tianming,ZHANG Shanshan,KONG Yan,YUE Ning,SHI Hui,HE Yuping,HU Huifang,LIU Furong,YANG Caixia. Clinical analysis of suspected COVID-19 patients with anxiety and depression. J Zhejiang Univ (Med Sci), 2020, 49(2): 203-208.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.03.02 或 http://www.zjujournals.com/med/CN/Y2020/V49/I2/203

表 1 伴发焦虑与不伴发焦虑的COVID-19疑似患者一般情况比较

表 2 伴发抑郁与不伴发抑郁的COVID-19疑似患者一般情况比较

表 3 COVID-19疑似患者伴发焦虑的多因素Logistic回归分析结果

表 4 COVID-19疑似患者伴发抑郁的多因素Logistic回归分析结果

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