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浙江大学学报（医学版）
浙江大学学报（医学版）  2019, Vol. 48 Issue (6): 682-687    DOI: 10.3785/j.issn.1008-9292.2019.12.14
综述     
组蛋白甲基化水平与骨关节炎病理发展的关联性
杜啸添1,2(),欧阳宏伟1,2,3,*()
1. 浙江大学医学院干细胞与再生医学系 浙江大学李达三·叶耀珍干细胞与再生医学研究中心, 浙江 杭州 310058
2. 浙江省组织工程与再生医学技术重点实验室, 浙江 杭州 310058
3. 浙江大学爱丁堡大学联合学院 浙江大学海宁国际校区, 浙江 海宁 314400
Correlation between histone methylation level and pathological development of osteoarthritis
DU Xiaotian1,2(),OUYANG Hongwei1,2,3,*()
1. Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China
2. Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
3. Zhejiang University-University of Edinburgh Institute, International Campus of Zhejiang University, Haining 314400, Zhejiang Province, China
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摘要：

骨关节炎是最常见的软骨退行性疾病。越来越多的研究显示，表观遗传学与骨关节炎之间密切相关，表观遗传修饰方式组蛋白甲基化水平与骨关节炎相关。组蛋白H3上不同氨基酸甲基化水平与骨关节炎病理发展的关联具体表现为第4位赖氨酸甲基化水平上升将加剧骨关节炎病理发展，而第9位与27位赖氨酸则呈现相反现象。因此，组蛋白甲基化修饰存在复杂网络，如能针对不同位置组蛋白的甲基化水平进行特异性靶向调控，有望延缓或阻止骨关节炎的发展。
关键词： 骨关节炎/病理学;  组蛋白类;  DNA甲基化;  综述    
Abstract:

Osteoarthritis is the most common degenerative cartilage disease. A large number of studies have shown the close association between epigenetics and osteoarthritis. Histone methylation is a type of epigenetic modification, and the link between histone methylation and osteoarthritis has also been revealed. In this article, we summarize the correlation between methylation levels of different histones and osteoarthritis in an attempt to explore the changes and regulation mechanisms of histone methylation in osteoarthritis. It has been shown that there are possible relations between the methylation levels of different amino acids on histone H3 and the pathological development of osteoarthritis; specifically, the rise of methylation level at the lysine 4 would aggravate the pathological development of osteoarthritis, while the the pattern of lysine 9 and 27 would be the opposite. These results indicate the possible existence of a complex network of histone methylation modifications. And the specific regulation of histone methylation levels in different positions may delay or prevent the occurrence and development of osteoarthritis.
Key words: Osteoarthritis/pathology    Histones    DNA methylation    Review
收稿日期: 2019-04-22 出版日期: 2020-01-19
:  R684.3  
基金资助: 国家自然科学基金(81630065)
通讯作者: 欧阳宏伟     E-mail: 21618580@zju.edu.cn;hwoy@zju.edu.cn
作者简介: 杜啸添(1991-), 男, 博士研究生, 主要从事骨关节炎表观遗传学修饰研究; E-mail:21618580@zju.edu.cn; https://orcid.org/0000-0002-7000-7828
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引用本文:

杜啸添,欧阳宏伟. 组蛋白甲基化水平与骨关节炎病理发展的关联性[J]. 浙江大学学报（医学版）, 2019, 48(6): 682-687.

DU Xiaotian,OUYANG Hongwei. Correlation between histone methylation level and pathological development of osteoarthritis. J Zhejiang Univ (Med Sci), 2019, 48(6): 682-687.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2019.12.14    或    http://www.zjujournals.com/med/CN/Y2019/V48/I6/682

组蛋白位置 对骨关节炎的作用 参考文献
H3K4：组蛋白H3上的第4位赖氨酸；H3K9：组蛋白H3上的第9位赖氨酸；H3K27：组蛋白H3上的第27位赖氨酸；H3K79：组蛋白H3上的第79位赖氨酸.
H3K4 加剧 [10-12]
H3K9 缓解 [13-14]
H3K27 缓解 [15-18]
加剧 [6, 19-21]
H3K79 缓解 [22-24]
表 1  组蛋白甲基化水平上升加剧或缓解骨关节炎作用一览
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