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浙江大学学报（医学版）
浙江大学学报（医学版）  2019, Vol. 48 Issue (6): 668-673    DOI: 10.3785/j.issn.1008-9292.2019.12.12
综述     
高原低氧对血脑屏障结构及其药物通透性影响的研究进展
丁怡丹1,2(),李文斌1,王荣1,2,*(),张建春3,*()
1. 解放军联勤保障部队第九四○医院全军高原环境损伤防治重点实验室, 甘肃 兰州 730050
2. 兰州大学药学院, 甘肃 兰州 730000
3. 中国人民解放军第一医院药剂科, 甘肃 兰州 730000
Research progress on the effects of plateau hypoxia on blood-brain barrier structure and drug permeability
DING Yidan1,2(),LI Wenbin1,WANG Rong1,2,*(),ZHANG Jianchun3,*()
1. Key Laboratory of Plateau Environmental Damage Prevention, the 940 th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China
2. School of Pharmacy, Lanzhou University, Lanzhou 730000, China
3. Department of Pharmacy, First Hospital of Chinese People's Liberation Army, Lanzhou 730000, China
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摘要：

中枢神经系统疾病治疗药物需通过血脑屏障进入脑组织发挥作用。在高原低氧环境下，血脑屏障组织结构中的紧密连接蛋白、星型胶质细胞和内皮细胞上的转运蛋白、内皮细胞上的ATP发生变化，同时血脑屏障通透性增加。这些变化是高原地区中枢神经系统疾病患者的合理用药的重要参考。本文就高原低氧对血脑屏障结构及其药物通透性影响的研究进展作一综述。
关键词： 中枢神经系统疾病;  血脑屏障;  高海拔;  高原病;  缺氧, 脑/病理生理学;  生物转运;  综述    
Abstract:

Drugs for the treatment of central nervous system diseases need to enter the brain tissue through the blood-brain barrier to function. In high altitude hypoxic environment, there are changes in tight junction proteins of blood-brain barrier tissue structure, transporters in astrocytes and endothelial cells and ATP in endothelial cells; at the same time the permeability of the blood-brain barrier is increased. These changes are an important reference for rational drug use in patients with central nervous system disease in the plateau region. This article reviews the research progress on the effects of plateau hypoxia on the structure of the blood-brain barrier and related drug permeability.
Key words: Central nervous system diseases    Blood-brain barrier    Altitude    Altitude sickness    Hypoxia, brain/physiopathology    Biological transport    Review
收稿日期: 2019-08-22 出版日期: 2020-01-19
:  R594.3  
基金资助: 国家自然科学基金(81673508)
通讯作者: 王荣,张建春     E-mail: dingyd17@lzu.edu.cn;wangrong-69@163.com;zjc1508@126.com
作者简介: 丁怡丹(1995-), 女, 硕士研究生, 主要从事高原药物转运体研究; E-mail:dingyd17@lzu.edu.cn; https://orcid.org/0000-0003-1196-5134
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引用本文:

丁怡丹,李文斌,王荣,张建春. 高原低氧对血脑屏障结构及其药物通透性影响的研究进展[J]. 浙江大学学报（医学版）, 2019, 48(6): 668-673.

DING Yidan,LI Wenbin,WANG Rong,ZHANG Jianchun. Research progress on the effects of plateau hypoxia on blood-brain barrier structure and drug permeability. J Zhejiang Univ (Med Sci), 2019, 48(6): 668-673.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2019.12.12    或    http://www.zjujournals.com/med/CN/Y2019/V48/I6/668

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