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浙江大学学报（医学版）
浙江大学学报（医学版）  2019, Vol. 48 Issue (3): 310-317    DOI: 10.3785/j.issn.1008-9292.2019.06.12
综述     
缰核及其神经环路在神经精神疾病中的作用研究进展
吴雨星(),张世红,陈忠*()
浙江大学医学院神经科学研究所, 杭州 浙江 310058
The roles of habenula and related neural circuits in neuropsychiatric diseases
WU Yuxing(),ZHANG Shihong,CHEN Zhong*()
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China
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摘要：

缰核是位于丘脑背侧的一个体积较小的双侧核团，含多种不同类型的神经元，与前额叶、隔核、中脑和脑干的单胺类核团有广泛的纤维联系。缰核是一个"反奖赏"核团，能被厌恶刺激和奖赏缺失激活，在多种对生存至关重要的行为中发挥作用。近年来，缰核在神经精神疾病中的作用越来越受到关注。本文综述了缰核在神经病理性疼痛、抑郁症、药物成瘾和精神分裂症中的作用及其环路机制，并讨论了缰核作为临床治疗靶点的可能性。
关键词： 缰核/生理学;  缰核/药物作用;  神经元/生理学;  神经元/药物作用;  疼痛;  抑郁症/遗传学;  物质相关性障碍;  精神分裂症;  综述    
Abstract:

The habenula is a small and bilateral nucleus above dorsal thalamus, which contains several different types of neurons. The habenula has extensive connections with the forebrain, septum and monoaminergic nuclei in the midbrain and brainstem. Habenula is known as an 'anti-reward' nucleus, which can be activated by aversive stimulus and negative reward prediction errors. Accumulating researchs have implicated that the habenula is involved in several behaviors crucial to survival. Meanwhile, the roles of the habenula in neuropsychiatric diseases have received increasing attention. This review summaries the studies regarding the roles of habenula and the related circuits in neuropathic pain, depression, drug addiction and schizophrenia, and discusses the possibility to use the habenula as a treatment target.
Key words: Habenula/physiology    Habenula/drug effects    Neurons/physiology    Neurons/drug effects    Pain    Depressive disorder/genetics    Substance-related disorders    Schizophrenia    Review
收稿日期: 2019-01-25 出版日期: 2019-09-04
CLC:  R74  
基金资助: 国家自然科学基金(81673404)
通讯作者: 陈忠     E-mail: wuyuxing@hrglobe.cn;chenzhong@zju.edu.cn
作者简介: 吴雨星(1993-), 女, 硕士研究生, 主要从事缰核在神经精神疾病中的作用研究; E-mail: wuyuxing@hrglobe.cn; https://orcid.org/0000-0002-3917-2454
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引用本文:

吴雨星, 张世红, 陈忠. 缰核及其神经环路在神经精神疾病中的作用研究进展[J]. 浙江大学学报（医学版）, 2019, 48(3): 310-317.

WU Yuxing, ZHANG Shihong, CHEN Zhong. The roles of habenula and related neural circuits in neuropsychiatric diseases. J Zhejiang Univ (Med Sci), 2019, 48(3): 310-317.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2019.06.12    或    http://www.zjujournals.com/med/CN/Y2019/V48/I3/310

图 1  缰核的神经纤维联系
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