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浙江大学学报（医学版）
浙江大学学报（医学版）  2019, Vol. 48 Issue (1): 111-115    DOI: 10.3785/j.issn.1008-9292.2019.02.16
综述     
细胞衰老与特发性肺纤维化的相关性研究进展
赵世浩(),张雪,柯越海*()
浙江大学医学院基础医学系, 浙江 杭州 310058
Progress on correlation between cell senescence and idiopathic pulmonary fibrosis
ZHAO Shihao(),ZHANG Xue,KE Yuehai*()
College of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China
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摘要：

细胞衰老是驱动衰老相关疾病的关键因素。衰老相关分泌表型、端粒损伤、表观遗传学改变、线粒体自噬受损等介导了细胞衰老相关特发性肺纤维化的发病；降低细胞衰老水平或清除衰老细胞可下调纤维化因子表达，缓解特发性肺纤维化进程。本文就近年来细胞衰老在特发性肺纤维化中的作用及机制研究进展作一综述。
关键词： 细胞衰老/病理学;  成纤维细胞/病理学;  上皮细胞/病理学;  肺纤维化/病理学;  综述    
Abstract:

Cellular senescence is a key factor driving age-related diseases. Recent studies have revealed that senescence-associated secretory phenotype, telomere attrition, epigenetic changes, and mitochondrial autophagy damage may mediate the pathogenesis of senescence-related idiopathic pulmonary fibrosis (IPF). Reducing the level of cellular senescence or clearing senescent cells can down-regulate the expression of fibrosis factors and alleviate the symptoms of IPF. In this review, we outlined the role and mechanism of cellular senescence in IPF.
Key words: Cell aging/pathology    Fibroblasts/pathology    Epithelial cells/pathology    Pulmonary fibrosis/pathology    Review
收稿日期: 2018-10-12 出版日期: 2019-05-13
:  R563  
基金资助: 国家自然科学基金(81530001)
通讯作者: 柯越海     E-mail: 21718492@zju.edu.cn;yke@zju.edu.cn
作者简介: 赵世浩(1995-), 男, 硕士研究生, 主要从事肺泡上皮稳态及炎症微环境的相关研究; E-mail:21718492@zju.edu.cn; https://orcid.org/0000-0002-9866-7844
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引用本文:

赵世浩,张雪,柯越海. 细胞衰老与特发性肺纤维化的相关性研究进展[J]. 浙江大学学报（医学版）, 2019, 48(1): 111-115.

ZHAO Shihao,ZHANG Xue,KE Yuehai. Progress on correlation between cell senescence and idiopathic pulmonary fibrosis. J Zhejiang Univ (Med Sci), 2019, 48(1): 111-115.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2019.02.16    或    http://www.zjujournals.com/med/CN/Y2019/V48/I1/111

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