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浙江大学学报（医学版）
浙江大学学报（医学版）  2019, Vol. 48 Issue (1): 34-38    DOI: 10.3785/j.issn.1008-9292.2019.02.06
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超声遗传学技术中的机械敏感性离子通道
洪非凡1(),李月舟1,2()
1. 浙江大学医学院生物物理系， 浙江 杭州 310058
2. 浙江大学医学院附属儿童医院实验检验中心， 浙江 杭州 310052
Application of mechanosensitive channels in sonogenetics
HONG Feifan1(),LI Yuezhou1,2()
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摘要：

超声遗传学技术是一种非侵入性神经调控手段。机械敏感性离子通道可以被低强度的超声激活而开放，达到调节可兴奋性细胞活性的目的，避免高强度超声对组织器官可能造成的损害。本文着重介绍了大电导机械敏感性离子通道、瞬时受体电位通道、双孔钾通道、Piezo等机械敏感性离子通道在超声神经调控中的研究进展及其应用，以期为超声遗传学研究提供参考。
关键词： 离子通道;  电生理学;  超声检查;  神经生理学;  神经元;  综述    
Abstract:

As a non-invasive approach, sonogenetics is applied to control neuronal activity. The mechanosensitive channel（MSC）, which has low threshold of responding to ultrasound, may be the alternative solution. Sonogenetics is the technique that activates the MSC expressed in targeted neurons by low intensity ultrasound, thus achieve the neuromodulation. In this review, we introduce the mechanosensitive channel of large conductance, transient receptor potential, channels of the two-pore-domain potassium family, Piezo and the recent progress on their application in sonogenetics.
Key words: Ion channels    Electrophysiology    Ultrasonography    Neurophysiology    Neurons    Review
收稿日期: 2018-08-21 出版日期: 2019-05-10
:  Q71  
基金资助: 国家自然科学基金(81527901，31270878)
通讯作者: 李月舟     E-mail: hongfeifanhff@qq.com;yuezhou-li@zju.edu.cn
作者简介: 洪非凡（1995—），男，硕士研究生，主要从事超声神经调控研究；E-mail：hongfeifanhff@qq.com； https://orcid.org/0000-0003-3792-906X|李月舟（1972—），男，博士，研究员，主要从事机械敏感性离子通道的功能和机制研究；E-mail：yuezhou-li@zju.edu.cn； https://orcid.org/ 0000-0003-0582-4255
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引用本文:

洪非凡,李月舟. 超声遗传学技术中的机械敏感性离子通道[J]. 浙江大学学报（医学版）, 2019, 48(1): 34-38.

HONG Feifan,LI Yuezhou. Application of mechanosensitive channels in sonogenetics. J Zhejiang Univ (Med Sci), 2019, 48(1): 34-38.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2019.02.06    或    http://www.zjujournals.com/med/CN/Y2019/V48/I1/34

图1  超声波调控神经活性的机制[15]
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