原著 |
|
|
|
|
基于尿液代谢组学技术研究尿毒清颗粒治疗慢性肾功能衰竭的机制 |
祝敏1( ),吴云秋2,寿张飞1,*( ) |
1. 树兰(杭州)医院肾脏病科, 浙江 杭州 310004 2. 江苏省中医药研究院, 江苏 南京 210028 |
|
Effects of Niaoduqing granule on urine metabolic profile in chronic renal failure rats |
ZHU Min1( ),WU Yunqiu2,SHOU Zhangfei1,*( ) |
1. Department of Nephrology, Shulan Hangzhou Hospital, Hangzhou 310004, China 2. Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China |
1 |
WANG P , WANG Q , YANG B et al. The progress of metabolomics study in traditional Chinese medicine research[J]. Am J Chin Med, 2015, 43 (7): 1281- 1310
doi: 10.1142/S0192415X15500731
|
2 |
吴昱铮, 王广基, 郝海平 . 中药代谢组学研究进展[J]. 中国药科大学学报, 2014, 45 (2): 129- 135 WU Yuzhen , WANG Guangji , HAO Haiping . Advances of metabolomic research of traditional Chinese medicine[J]. Journal of China Pharmaceutical University, 2014, 45 (2): 129- 135
|
3 |
范仕成, 高悦, 张慧贞 et al. 非靶向和靶向代谢组学在药物靶点发现中的应用[J]. 药学进展, 2017, 41 (4): 263- 269 FAN Shicheng , GAO Yue , ZHANG Huizhen et al. Untargeted and targeted metabolomics and their applications in discovering drug targets[J]. Progress in Pharmaceutical Sciences, 2017, 41 (4): 263- 269
|
4 |
任向楠, 梁琼麟 . 基于质谱分析的代谢组学研究进展[J]. 分析测试学报, 2017, 36 (2): 161- 169 REN Xiangnan , LIANG Qionglin . Advance in metabolomics based on mass spectrometry[J]. Journal of Instrumental Analysis, 2017, 36 (2): 161- 169
doi: 10.3969/j.issn.1004-4957.2017.02.002
|
5 |
WANT E J , NORDSTR?M A , MORITA H et al. From exogenous to endogenous:the inevitable imprint of mass spectrometry in metabolomics[J]. J Proteome Res, 2007, 6 (2): 459- 468
doi: 10.1021/pr060505+
|
6 |
QI Y , PI Z , LIU S et al. A metabonomic study of adjuvant-induced arthritis in rats using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry[J]. Mol Biosyst, 2014, 10 (10): 2617- 2625
doi: 10.1039/C4MB00131A
|
7 |
刘建璟.肾宁合剂治疗慢性肾功能衰竭大鼠的实验研究[D].南京: 南京中医药大学, 2011. LIU Jianjing. Experiment on chronic renal failure rats treated with Shenning Heji[D]. Nanjing: Nanjing University of Chinese Medicine, 2011. (in Chinese)
|
8 |
汪远霞, 俞国庆, 苏晓英 et al. 尿毒清颗粒对早中期慢性肾衰竭患者微炎症状态的作用[J]. 中国中西医结合肾病杂志, 2016, 17 (12): 1050- 1052 WANG Yuanxia , YU Guoqing , SU Xiaoying et al. The ameliorating effect of uremic clearance granule played on micro-inflammatory state for patients in early and mild stage of chronic renal insuficiency[J]. Chinese Journal of Integrated Traditional and Western Nephrology, 2016, 17 (12): 1050- 1052
doi: 10.3969/j.issn.1009-587X.2016.12.006
|
9 |
张宁, 曾涛, 张侃 et al. 尿毒清颗粒联合饮食干预对慢性肾功能衰竭患者血清Chemerin、VEGF的影响[J]. 实用药物与临床, 2017, 20 (10): 1148- 1152 ZHANG Ning , ZENG Tao , ZHANG Kan et al. Effect of Niaoduqing particles combined with diet intervention on serum chemerin and VEGF in patients with chronic renal failure[J]. Practical Pharmacy and Clinical Remedies, 2017, 20 (10): 1148- 1152
|
10 |
李春雨, 王平, 王张 et al. 基于代谢组学技术的大黄治疗慢性肾功能衰竭的作用机制研究[J]. 中草药, 2012, 43 (2): 312- 315 LI Chunyu , WANG Ping , WANG Zhang et al. Mechanism study of Rheum officinale on chronic renal failure based on metabolomics[J]. Chinese Traditional and Herbal Drugs, 2012, 43 (2): 312- 315
|
11 |
宋慧婷, 李长印, 万瑶瑶 et al. 黄芪口服液降低大鼠顺铂毒性作用机制的尿液代谢组学研究[J]. 分析化学, 2017, 45 (4): 565- 573 SONG Huiting , LI Changyin , WAN Yaoyao et al. Untargeted urinary metabolomicstudy on toxicity-alleviation effect of Huangqioral solution in cisplatin-exposed rats[J]. Chinese Journal of Analytical Chemistry, 2017, 45 (4): 565- 573
|
12 |
贺冲.花生四烯酸代谢网络动力学调控研究与抑制剂设计[D].北京: 北京大学, 2011. HE Chong. Quantitative study on the arachidonic acid metabolic network dynamics, intervention and inhibitor design[D]. Beijing: Peking University, 2011. (in Chinese)
|
13 |
余军, 赵维星, 杜春彦 et al. 胆碱改善脂多糖诱导的小鼠中枢神经系统炎症反应及认知功能障碍[J]. 南方医科大学学报, 2017, 37 (5): 600- 606 YU Jun , ZHAO Weixing , DU Chunyan et al. Choline improves lipopolysaccharide-induced central nervous system inflammatory response and cognitive dysfunction in mice[J]. Journal of Southern Medical University, 2017, 37 (5): 600- 606
|
14 |
赵保胜, 刘洋, 高晓燕 et al. 棕榈酸对C2C12细胞Toll样受体及其炎症因子表达的影响[J]. 中国临床药理学与治疗学, 2012, 17 (11): 1201- 1205 ZHAO Baosheng , LIU Yang , GAO Xiaoyan et al. The influence of palmitic acid to TLRs and inflammatory factors of C2C12 cell line[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17 (11): 1201- 1205
|
15 |
TAO Y Q , LIANG T , ZHOU K Y . Three arachidonic acid metabolic pathways involved in inflammation[J]. Int J Immunol, 2010, 33 (4): 303- 306
|
16 |
岳贺, 周祥羽, 李春苑 et al. 交泰丸干预对氯苯丙氨酸致大鼠失眠的代谢组学研究[J]. 中国中药杂志, 2016, 41 (18): 3451- 3456 YUE He , ZHOU Xiangyu , LI Chunyuan et al. Intervention effects of Jiaotai pills on PCPA-induced insomnia in rats[J]. China Journal of Chinese Materia Medica, 2016, 41 (18): 3451- 3456
|
17 |
王敦方, 王彦礼, 王怡薇 et al. 基于UHPLC-MS研究黄芩汤对溃疡性结肠炎大鼠血清代谢谱的影响[J]. 药学学报, 2017, 52 (8): 1306- 1312 WANG Dunfang , WANG Yanli , WANG Yiwei et al. Effect of Huangqin Tang on serum metabolic profile in rats withulcerative colitis based on UHPLC-MS[J]. Acta Pharmaceutica Sinica, 2017, 52 (8): 1306- 1312
|
18 |
袁发焕, 廖立生 . 慢性肾衰大鼠肾组织内炎性细胞浸润机理探讨[J]. 四川医学, 1993, 14 (10): 599- 600 YUANG Fahuan , LIAO Lisheng . Mechanism of inflammatory cell infiltration in kidney tissue of rats with chronic renal failure[J]. Sichuan Medical Journal, 1993, 14 (10): 599- 600
|
19 |
凃杰, 刘苗苗, 吴玥 et al. 石榴皮鞣质对慢性肾小球肾炎大鼠内源性代谢物的影响[J]. 中国医院药学杂志, 2015, 35 (8): 673- 678 TU Jie , LIU Miaomiao , WU Yue et al. Effects of tannins in pomegranate rind on endogenous metabolites in rats with chronic glomerulonephritis[J]. Chinese Journal of Hospital Pharmacy, 2015, 35 (8): 673- 678
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
|
Shared |
|
|
|
|
|
Discussed |
|
|
|
|