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基于间充质干细胞的小分子化学药物肿瘤靶向递送系统研究进展 |
王晓玲1,2( ),欧阳旭梅1,2,孙晓译1,*( ) |
1. 浙江大学城市学院医学院药学系, 浙江 杭州 310015 2. 浙江大学药学院, 浙江 杭州 310058 |
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Application of mesenchymal stem cells in antineoplastic drugs delivery for tumor-targeted therapy |
WANG Xiaoling1,2( ),OUYANG Xumei1,2,SUN Xiaoyi1,*( ) |
1. Department of Pharmacy, Zhejiang University City College, Hangzhou 310015, China 2. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China |
1 |
CHULPANOVA D S , KITAEVA K V , TAZETDINOVA L G et al. Application of mesenchymal stem cells for therapeutic agent delivery in anti-tumor treatment[J]. Front Pharmacol, 2018, 9:259
doi: 10.3389/fphar.2018.00259
|
2 |
FURLANI D , UGURLUCAN M , ONG L et al. Is the intravascular administration of mesenchymal stem cells safe? Mesenchymal stem cells and intravital microscopy[J]. Microvasc Res, 2009, 77 (3): 370- 376
doi: 10.1016/j.mvr.2009.02.001
|
3 |
LEE R H , PULIN A A , SEO M J et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6[J]. Cell Stem Cell, 2009, 5 (1): 54- 63
doi: 10.1016/j.stem.2009.05.003
|
4 |
WANG X , CHEN H , ZENG X et al. Efficient lung cancer-targeted drug delivery via a nanoparticle/MSC system[J]. Acta Pharm Sin B, 2018, in press
|
5 |
NYSTEDT J , ANDERSON H , TIKKANEN J et al. Cell surface structures influence lung clearance rate of systemically infused mesenchymal stromal cells[J]. Stem Cells, 2013, 31 (2): 317- 326
doi: 10.1002/stem.v31.2
|
6 |
GHOLAMREZANEZHAD A , MIRPOUR S , BAGHERI M et al. In vivo tracking of 111In-oxine labeled mesenchymal stem cells following infusion in patients with advanced cirrhosis[J]. Nucl Med Biol, 2011, 38 (7): 961- 967
doi: 10.1016/j.nucmedbio.2011.03.008
|
7 |
KIM S M , JEONG C H , WOO J S et al. In vivo near-infrared imaging for the tracking of systemically delivered mesenchymal stem cells:tropism for brain tumors and biodistribution[J]. Int J Nanomedicine, 2016, 11:13- 23
|
8 |
DE WITTE S F H , LUK F , SIERRA P J M et al. Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells[J]. Stem Cells, 2018, 36 (4): 602- 615
doi: 10.1002/stem.v36.4
|
9 |
GALLEU A , RIFFO-VASQUEZ Y , TRENTO C et al. Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation[J]. Sci Transl Med, 2017, 9 (416): eaam7828
doi: 10.1126/scitranslmed.aam7828
|
10 |
TEG K , DLJ T , DENMEADE S R et al. Concise review:mesenchymal stem cell-based drug delivery:the good, the bad, the ugly, and the promise[J]. Stem Cells Transl Med, 2018, 7 (9): 651- 663
doi: 10.1002/sctm.18-0024
|
11 |
TOMA C , WAGNER W R , BOWRY S et al. Fate of culture-expanded mesenchymal stem cells in the microvasculature:in vivo observations of cell kinetics[J]. Circ Res, 2009, 104 (3): 398- 402
doi: 10.1161/CIRCRESAHA.108.187724
|
12 |
FISCHER U M , HARTING M T , JIMENEZ F et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery:the pulmonary first-pass effect[J]. Stem Cells Dev, 2009, 18 (5): 683- 692
doi: 10.1089/scd.2008.0253
|
13 |
ZANETTI A , GRATA M , ETLING E B et al. Suspension-expansion of bone marrow results in small mesenchymal stem cells exhibiting increased transpulmonary passage following intravenous administration[J]. Tissue Eng Part C Methods, 2015, 21 (7): 683- 692
doi: 10.1089/ten.tec.2014.0344
|
14 |
GILAZIEVA Z , TAZETDINOVA L , ARKHIPOVA S et al. Effect of cisplatin on ultrastructure and viability of adipose-derived mesenchymal stem cells[J]. Bio Nano Science, 2016, 6 (4): 534- 539
|
15 |
NICOLAY N H , LOPEZ P R , RVHLE A et al. Mesenchymal stem cells maintain their defining stem cell characteristics after treatment with cisplatin[J]. Sci Rep, 2016, 6:20035
doi: 10.1038/srep20035
|
16 |
PESSINA A, BONOMI A, COCCè V, et al. Mesenchymal stromal cells primed with paclitaxel provide a new approach for cancer therapy[J/OL]. PLoS One, 2011, 6(12): e28321.
|
17 |
BONOMI A , SILINI A , VERTUA E et al. Human amniotic mesenchymal stromal cells (hAMSCs) as potential vehicles for drug delivery in cancer therapy:an in vitro study[J]. Stem Cell Res Ther, 2015, 6 (1): 155
|
18 |
PETRELLA F , COCCè V , MASIA C et al. Paclitaxel-releasing mesenchymal stromal cells inhibit in vitro proliferation of human mesothelioma cells[J]. Biomed Pharmacother, 2017, 87:755- 758
doi: 10.1016/j.biopha.2017.01.118
|
19 |
BONOMI A , STEIMBERG N , BENETTI A et al. Paclitaxel-releasing mesenchymal stromal cells inhibit the growth of multiple myeloma cells in a dynamic 3D culture system[J]. Hematol Oncol, 2017, 35 (4): 693- 702
doi: 10.1002/hon.v35.4
|
20 |
PESSINA A , COCCè V , PASCUCCI L et al. Mesenchymal stromal cells primed with Paclitaxel attract and kill leukaemia cells, inhibit angiogenesis and improve survival of leukaemia-bearing mice[J]. Br J Haematol, 2013, 160 (6): 766- 778
doi: 10.1111/bjh.12196
|
21 |
BRINI A T , COCCè V , FERREIRA L M et al. Cell-mediated drug delivery by gingival interdental papilla mesenchymal stromal cells (GinPa-MSCs) loaded with paclitaxel[J]. Expert Opin Drug Deliv, 2016, 13 (6): 789- 798
|
22 |
COCCè V , FARRONATO D , BRINI A T et al. Drug loaded gingival mesenchymal stromal cells (GinPa-MSCs) inhibit in vitro proliferation of oral squamous cell carcinoma[J]. Sci Rep, 2017, 7 (1): 9376
doi: 10.1038/s41598-017-09175-4
|
23 |
COCCE V , BALDUCCI L , FALCHETTI M L et al. Fluorescent immortalized human adipose derived stromal cells (hASCs-TS/GFP+) for studying cell drug delivery mediated by microvesicles[J]. Anticancer Agents Med Chem, 2017, 17 (11): 1578- 1585
|
24 |
PASCUCCI L , COCCè V , BONOMI A et al. Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth:a new approach for drug delivery[J]. J Control Release, 2014, 192:262- 270
doi: 10.1016/j.jconrel.2014.07.042
|
25 |
PESSINA A , LEONETTI C , ARTUSO S et al. Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model[J]. J Exp Clin Cancer Res, 2015, 34:82
doi: 10.1186/s13046-015-0200-3
|
26 |
PACIONI S , D'ALESSANDRIS Q G , GIANNETTI S et al. Mesenchymal stromal cells loaded with paclitaxel induce cytotoxic damage in glioblastoma brain xenografts[J]. Stem Cell Res Ther, 2015, 6:194
doi: 10.1186/s13287-015-0185-z
|
27 |
BONOMI A , GHEZZI E , PASCUCCI L et al. Effect of canine mesenchymal stromal cells loaded with paclitaxel on growth of canine glioma and human glioblastoma cell lines[J]. Vet J, 2017, 223:41- 47
doi: 10.1016/j.tvjl.2017.05.005
|
28 |
KALIMUTHU S , ZHU L , OH J M et al. Migration of mesenchymal stem cells to tumor xenograft models and in vitro drug delivery by doxorubicin[J]. Int J Med Sci, 2018, 15 (10): 1051- 1061
doi: 10.7150/ijms.25760
|
29 |
BONOMI A , SORDI V , DUGNANI E et al. Gemcitabine-releasing mesenchymal stromal cells inhibit in vitro proliferation of human pancreatic carcinoma cells[J]. Cytotherapy, 2015, 17 (12): 1687- 1695
doi: 10.1016/j.jcyt.2015.09.005
|
30 |
RIMOLDI I , COCCè V , FACCHETTI G et al. Uptake-release by MSCs of a cationic platinum(Ⅱ) complex active in vitro on human malignant cancer cell lines[J]. Biomed Pharmacother, 2018, 108:111- 118
doi: 10.1016/j.biopha.2018.09.040
|
31 |
CLAVREUL A , POURBAGHI-MASOULEH M , ROGER E et al. Human mesenchymal stromal cells as cellular drug-delivery vectors for glioblastoma therapy:a good deal?[J]. J Exp Clin Cancer Res, 2017, 36 (1): 135
doi: 10.1186/s13046-017-0605-2
|
32 |
YAO S , LI X , LIU J et al. Maximized nanodrug-loaded mesenchymal stem cells by a dual drug-loaded mode for the systemic treatment of metastatic lung cancer[J]. Drug Deliv, 2017, 24 (1): 1372- 1383
doi: 10.1080/10717544.2017.1375580
|
33 |
DAI T , YANG E , SUN Y et al. Preparation and drug release mechanism of CTS-TAX-NP-MSCs drug delivery system[J]. Int J Pharm, 2013, 456 (1): 186- 194
doi: 10.1016/j.ijpharm.2013.07.070
|
34 |
SADHUKHA T , O'BRIEN T D , PRABHA S . Nano-engineered mesenchymal stem cells as targeted therapeutic carriers[J]. J Control Release, 2014, 196:243- 251
doi: 10.1016/j.jconrel.2014.10.015
|
35 |
WANG X , GAO J , OUYANG X et al. Mesenchymal stem cells loaded with paclitaxel-poly(lactic-co-glycolic acid) nanoparticles for glioma-targeting therapy[J]. Int J Nanomedicine, 2018, 13:5231- 5248
doi: 10.2147/IJN
|
36 |
YANES R E , TARN D , HWANG A A et al. Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition[J]. Small, 2013, 9 (5): 697- 704
doi: 10.1002/smll.v9.5
|
37 |
OH N , PARK J H . Endocytosis and exocytosis of nanoparticles in mammalian cells[J]. Int J Nanomedicine, 2014, 9 (Suppl 1): 51- 63
|
38 |
SAKHTIANCHI R , MINCHIN R F , LEE K B et al. Exocytosis of nanoparticles from cells:role in cellular retention and toxicity[J]. Adv Colloid Interface Sci, 2013, 201-202:18- 29
doi: 10.1016/j.cis.2013.10.013
|
39 |
EL-DAKDOUKI M H , PURé E , HUANG X . Development of drug loaded nanoparticles for tumor targeting. Part 2:Enhancement of tumor penetration through receptor mediated transcytosis in 3D tumor models[J]. Nanoscale, 2013, 5 (9): 3904- 3911
doi: 10.1039/c3nr90022c
|
40 |
LIU S L , ZHANG Z L , SUN E Z et al. Visualizing the endocytic and exocytic processes of wheat germ agglutinin by quantum dot-based single-particle tracking[J]. Biomaterials, 2011, 32 (30): 7616- 7624
doi: 10.1016/j.biomaterials.2011.06.046
|
41 |
ROGER M , CLAVREUL A , VENIER-JULIENNE M C et al. Mesenchymal stem cells as cellular vehicles for delivery of nanoparticles to brain tumors[J]. Biomaterials, 2010, 31 (32): 8393- 8401
doi: 10.1016/j.biomaterials.2010.07.048
|
42 |
LAYEK B , SADHUKHA T , PANYAM J et al. Nano-engineered mesenchymal stem cells increase therapeutic efficacy of anticancer drug through true active tumor targeting[J]. Mol Cancer Ther, 2018, 17 (6): 1196- 1206
doi: 10.1158/1535-7163.MCT-17-0682
|
43 |
ZHAO Y , TANG S , GUO J et al. Targeted delivery of doxorubicin by nano-loaded mesenchymal stem cells for lung melanoma metastases therapy[J]. Sci Rep, 2017, 7:44758
doi: 10.1038/srep44758
|
44 |
ZHANG X , YAO S , LIU C et al. Tumor tropic delivery of doxorubicin-polymer conjugates using mesenchymal stem cells for glioma therapy[J]. Biomaterials, 2015, 39:269- 281
doi: 10.1016/j.biomaterials.2014.11.003
|
45 |
DUCHI S , SOTGIU G , LUCARELLI E et al. Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles:effective photoinduced in vitro killing of osteosarcoma[J]. J Control Release, 2013, 168 (2): 225- 237
doi: 10.1016/j.jconrel.2013.03.012
|
46 |
CAO S , GUO J , HE Y et al. Nano-loaded human umbilical cord mesenchymal stem cells as targeted carriers of doxorubicin for breast cancer therapy[J]. Artif Cells Nanomed Biotechnol, 2018, 1- 11
|
47 |
PARIS J L , DE LA TORRE P , MANZANO M et al. Decidua-derived mesenchymal stem cells as carriers of mesoporous silica nanoparticles. In vitro and in vivo evaluation on mammary tumors[J]. Acta Biomater, 2016, 33:275- 282
doi: 10.1016/j.actbio.2016.01.017
|
48 |
WU J , LIU Y , TANG Y et al. Synergistic chemo-photothermal therapy of breast cancer by mesenchymal stem cell-encapsulated yolk-shell GNR@HPMO-PTX nanospheres[J]. ACS Appl Mater Interfaces, 2016, 8 (28): 17927- 17935
doi: 10.1021/acsami.6b05677
|
49 |
KANG S , BHANG S H , HWANG S et al. Mesenchymal stem cells aggregate and deliver gold nanoparticles to tumors for photothermal therapy[J]. ACS Nano, 2015, 9 (10): 9678- 9690
doi: 10.1021/acsnano.5b02207
|
50 |
HEREA D D , LABUSCA L , RADU E et al. Human adipose-derived stem cells loaded with drug-coated magnetic nanoparticles for in-vitro tumor cells targeting[J]. Mater Sci Eng C Mater Biol Appl, 2019, 94:666- 676
doi: 10.1016/j.msec.2018.10.019
|
51 |
ROGER M , CLAVREUL A , HUYNH N T et al. Ferrociphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy[J]. Int J Pharm, 2012, 423 (1): 63- 68
|
52 |
HO Y J , CHIANG Y J , KANG S T et al. Camptothecin-loaded fusogenic nanodroplets as ultrasound theranostic agent in stem cell-mediated drug-delivery system[J]. J Control Release, 2018, 278:100- 109
doi: 10.1016/j.jconrel.2018.04.001
|
53 |
WANG Q , CHENG H , PENG H et al. Non-genetic engineering of cells for drug delivery and cell-based therapy[J]. Adv Drug Deliv Rev, 2015, 91:125- 140
doi: 10.1016/j.addr.2014.12.003
|
54 |
CHENG H , KASTRUP C J , RAMANATHAN R et al. Nanoparticulate cellular patches for cell-mediated tumoritropic delivery[J]. ACS nano, 2010, 4 (2): 625- 631
doi: 10.1021/nn901319y
|
55 |
LI L , GUAN Y , LIU H et al. Silica nanorattle-doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy[J]. ACS Nano, 2011, 5 (9): 7462- 7470
doi: 10.1021/nn202399w
|
56 |
SURYAPRAKASH S , LI M , LAO Y H et al. Graphene oxide cellular patches for mesenchymal stem cell-based cancer therapy[J]. Carbon, 2018, 129:863- 868
doi: 10.1016/j.carbon.2017.12.031
|
57 |
KLOPP A H , GUPTA A , SPAETH E et al. Concise review:dissecting a discrepancy in the literature:do mesenchymal stem cells support or suppress tumor growth?[J]. Stem Cells, 2011, 29 (1): 11- 19
doi: 10.1002/stem.559
|
58 |
SHI Y , DU L , LIN L et al. Tumour-associated mesenchymal stem/stromal cells:emerging therapeutic targets[J]. Nat Rev Drug Discov, 2017, 16 (1): 35- 52
|
59 |
ZHANG T Y , HUANG B , WU H B et al. Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice[J]. J Control Release, 2015, 209:260- 271
doi: 10.1016/j.jconrel.2015.05.007
|
60 |
PACIONI S , D'ALESSANDRIS Q G , GIANNETTI S et al. Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts[J]. Stem Cell Res Ther, 2017, 8 (1): 53
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