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浙江大学学报(医学版)  2018, Vol. 47 Issue (4): 435-440    DOI: 10.3785/j.issn.1008-9292.2018.08.17
综述     
系统性红斑狼疮合并器官特异性自身免疫性疾病的相关研究进展
王星星1(),王盼盼2,杨旭燕1,*()
1. 浙江大学医学院附属第二医院风湿免疫科, 浙江 杭州 310009
2. 成都中医药大学附属医院内分泌科, 四川 成都 610075
Research progress on systemic lupus erythematosus overlapping organ-specific autoimmune diseases
WANG Xingxing1(),WANG Panpan2,YANG Xuyan1,*()
1. Department of Rheumatism and Immunology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
2. Department of Endocrinology, Chengdu University of TCM, Chengdu 610075, China
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摘要:

系统性红斑狼疮(SLE)是一种多器官多系统累及的自身免疫性疾病,可以与器官特异性自身免疫性疾病如自身免疫性甲状腺疾病、自身免疫性肝炎、炎性肠疾病同时存在。SLE与这三种器官特异性自身免疫性疾病可能存在某种关联性,如相似的免疫学及基因背景,但其机制尚不清楚。本文就SLE合并上述三种自身免疫性疾病的可能机制、发病率和临床特征等作一综述。

关键词: 红斑狼疮, 系统性甲状腺炎, 自身免疫性肝炎, 自身免疫性结肠炎, 溃疡性克罗恩病综述    
Abstract:

Systemic lupus erythematosus (SLE) is a multiorgan-involved autoimmune disease, and it can overlap organ-specific autoimmune diseases such as autoimmune thyroid diseases, autoimmune hepatitis and inflammatory bowel disease. There may be some association between SLE and these autoimmune diseases, such as common immunological and genetic basis, but the pathogenic mechanism is still unclear. This review focuses on current knowledge regarding the prevalence and possible pathogenesis of SLE overlapping the above three autoimmune diseases.

Key words: Lupus erythematosus, systemic    Thyroiditis, autoimmune    Hepatitis, autoimmune    Colitis, ulcerative    Crohn disease    Review
收稿日期: 2018-04-10 出版日期: 2018-12-04
:  R593.24+1  
基金资助: 浙江省自然科学基金(Y15H1000006);国家自然科学基金(81571578)
通讯作者: 杨旭燕     E-mail: 21618189@zju.edu.cn;13819186380@163.com
作者简介: 王星星(1991-), 女, 硕士研究生, 主要从事系统性红斑狼疮的临床研究; E-mail:21618189@zju.edu.cn; https://orcid.org/0000-0001-9939-1096
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引用本文:

王星星,王盼盼,杨旭燕. 系统性红斑狼疮合并器官特异性自身免疫性疾病的相关研究进展[J]. 浙江大学学报(医学版), 2018, 47(4): 435-440.

WANG Xingxing,WANG Panpan,YANG Xuyan. Research progress on systemic lupus erythematosus overlapping organ-specific autoimmune diseases. J Zhejiang Univ (Med Sci), 2018, 47(4): 435-440.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2018.08.17        http://www.zjujournals.com/med/CN/Y2018/V47/I4/435

1 ARKEMA E V, SIMARD J F. Cohort profile: systemic lupus erythematosus in Sweden: the Swedish Lupus Linkage (SLINK) cohort[J/OL]. BMJ Open, 2015, 5(8): e008259.
2 MOLINELLI E , GIULIODORI K , CAMPANATI A et al. Coexistence of systemic lupus erythematosus, Hashimoto's thyroiditis, and bilateral breast cancer in the same patient:a random association?[J]. Acta Dermatovenerol Alp Pannonica Adriat, 2015, 24 (3): 55- 57
3 RASAEI N, SHAMS M, KAMALI-SARVESTANI E, et al. The prevalence of thyroid dysfunction in patients with systemic lupus erythematosus[J/OL]. Iran Red Crescent Med J, 2015, 17(12): e17298.
4 BATTAGLIOTTI C, RISPOLO K D, KARAKACHOFF M, et al. An overlap syndrome involving systemic lupus erythematosus and autoimmune hepatitis in an adolescent girl[J/OL]. Arch Argent Pediatr, 2016, 114(3): e155-e158.
5 YAMASHITA H , UEDA Y , KAWAGUCHI H et al. Systemic lupus erythematosus complicated by Crohn's disease:a case report and literature review[J]. BMC Gastroenterol, 2012, 12 174
doi: 10.1186/1471-230X-12-174
6 ROBAZZI T C , ADAN L F . Autoimmune thyroid disease in patients with rheumatic diseases[J]. Rev Bras Reumatol, 2012, 52 (3): 417- 430
7 ANTONELLI A , FERRARI S M , CORRADO A et al. Autoimmune thyroid disorders[J]. Autoimmun Rev, 2015, 14 (2): 174- 180
doi: 10.1016/j.autrev.2014.10.016
8 NAMJOU B , KELLY J A , KILPATRICK J et al. Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease[J]. Arthritis Rheum, 2005, 52 (11): 3646- 3650
9 WU H , CANTOR R M , GRAHAMD S et al. Association analysis of the R620W polymorphism of protein tyrosine phosphatase PTPN22 in systemic lupus erythematosus families:increased T allele frequency in systemic lupus erythematosus patients with autoimmune thyroid disease[J]. Arthritis Rheum, 2005, 52 (8): 2396- 2402
doi: 10.1002/(ISSN)1529-0131
10 PHENEKOS C , VRYONIDOU A , GRITZAPIS A D et al. Th1 and Th2 serum cytokine profiles characterize patients with Hashimoto's thyroiditis(Th1) and Graves' disease (Th2)[J]. Neuroimmunomodulation, 2004, 11 (4): 209- 213
doi: 10.1159/000078438
11 杨佳荟, 刘莉, 郭品娥 et al. 系统性红斑狼疮病人外周血Th细胞和Tc细胞IFN-γ及IL-4表达水平与疾病的关系[J]. 中国免疫学杂志, 2006, 22 (2): 186- 190
YANG Jiahui , LIU Li , GUO Pin'e et al. Measurement of intracellular interferon-γ and interleukin-4 in whole blood Th and Tc lymphocytes from patients with systemi lupus erythematosus[J]. Chinese Journal of Immunology, 2006, 22 (2): 186- 190
doi: 10.3321/j.issn:1000-484X.2006.02.022
12 FERRARI S M , ELIA G , VIRILI C et al. Systemic lupus erythematosus and thyroid autoimmunity[J]. Front Endocrinol(Lausanne), 2017, 8 138
doi: 10.3389/fendo.2017.00138
13 郭庆敏, 禚志红, 王怀立 et al. Graves病合并系统性红斑狼疮1例分析[J]. 临床儿科杂志, 2014, 32 (12): 1122- 1125
GUO Qingmin , ZHOU Zhihong , WANG Huaili et al. One case of childhood Graves' disease complicated with systemic lupus erythematosus:clinical manifestation and diagnosis[J]. Journal of Clinical Pediatrics, 2014, 32 (12): 1122- 1125
doi: 10.3969/j.issn.1000-3606.2014.12.08
14 LIU Y C , LIN W Y , TSAIM C et al. Systemic lupus erythematosus and thyroid disease-experience in a single medical center in Taiwan[J]. J Microbiol Immunol Infect, 2017, pii:S1684-1182 (17): 30084-1
15 WATAD A , MAHROUM N , WHITBY A et al. Hypothyroidism among SLE patients:Case-control study[J]. Autoimmun Rev, 2016, 15 (5): 484- 486
doi: 10.1016/j.autrev.2016.01.019
16 WATAD A , COHEN A D , COMANESHTER D et al. Hyperthyroidism association with SLE, lessons from real-life data-a case-control study[J]. Autoimmunity, 2016, 49 (1): 17- 20
doi: 10.3109/08916934.2015.1090985
17 ANTONELLI A , FALLAHI P , MOSCA M et al. Prevalence of thyroid dysfunctions in systemic lupus erythematosus[J]. Metabolism, 2010, 59 (6): 896- 900
doi: 10.1016/j.metabol.2009.10.010
18 MIHAILOVA D , GRIGOROVA R , VASSILEVA B et al. Autoimmune thyroid disorders in juvenile chronic arthritis and systemic lupus erythematosus[J]. Adv Exp Med Biol, 1999, 455 55- 60
doi: 10.1007/978-1-4615-4857-7
19 PAN X F, GU J Q, SHANZ Y. Patients with systemic lupus erythematosus have higher prevalence of thyroid autoantibodies: a systematic review and meta-analysis[J/OL]. PLoS One, 2015, 10(4): e0123291.
20 CATUREGLI P , DE REMIGIS A , ROSE N R . Hashimoto thyroiditis:clinical and diagnostic criteria[J]. Autoimmun Rev, 2014, 13 (4-5): 391- 397
doi: 10.1016/j.autrev.2014.01.007
21 PYZIK A , GRYWALSKA E , MATYJASZEK-MATUSZEK B et al. Immune disorders in Hashimoto's thyroiditis:what do we know so far?[J]. J Immunol Res, 2015, 2015 979167
22 LIBERAL R , KRAWITT E L , VIERLING J M et al. Cutting edge issues in autoimmune hepatitis[J]. J Autoimmun, 2016, 75 6- 19
doi: 10.1016/j.jaut.2016.07.005
23 USTA Y , GURAKAN F , AKCOREN Z et al. An overlap syndrome involving autoimmune hepatitis and systemic lupus erythematosus in childhood[J]. World J Gastroenterol, 2007, 13 (19): 2764- 2767
doi: 10.3748/wjg.v13.i19.2764
24 BENTHAM J , MORRIS D L , DSC G et al. Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus[J]. Nat Genet, 2015, 47 (12): 1457- 1464
doi: 10.1038/ng.3434
25 RUNYON B A , LABRECQUE D R , ANURAS S . The spectrum of liver disease in systemic lupus erythematosus. Report of 33 histologically-proved cases and review of the literature[J]. Am J Med, 1980, 69 (2): 187- 194
doi: 10.1016/0002-9343(80)90378-2
26 VAN HOEK B . The spectrum of liver disease in systemic lupus erythematosus[J]. Neth J Med, 1996, 48 (6): 244- 253
doi: 10.1016/0300-2977(96)00003-4
27 EBERT E C , HAGSPIEL K D . Gastrointestinal and hepatic manifestations of systemic lupus erythematosus[J]. J Clin Gastroenterol, 2011, 45 (5): 436- 441
doi: 10.1097/MCG.0b013e31820f81b8
28 BEISEL C , WEILER-NORMANN C , TEUFEL A et al. Association of autoimmune hepatitis and systemic lupus erythematodes:a case series and review of the literature[J]. World J Gastroenterol, 2014, 20 (35): 12662- 12667
doi: 10.3748/wjg.v20.i35.12662
29 BESSONE F , POLES N , ROMAM G . Challenge of liver disease in systemic lupus erythematosus:Clues for diagnosis and hints for pathogenesis[J]. World J Hepatol, 2014, 6 (6): 394- 409
doi: 10.4254/wjh.v6.i6.394
30 IRVING K S , SEN D , TAHIR H et al. A comparison of autoimmune liver disease in juvenile and adult populations with systemic lupus erythematosus-a retrospective review of cases[J]. Rheumatology(Oxford), 2007, 46 (7): 1171- 1173
doi: 10.1093/rheumatology/kem108
31 OLESI?SKA M , CHWALI?SKA-SADOWSKA H , WIESIK-SZEWCZYK E et al. Clinical manifestation of systemic lupus erythematosus in patients with antiribosomal P protein antibodies[J]. Pol Arch Med Wewn, 2010, 120 (3): 76- 81
32 OHIRA H , TAKIGUCHI J , RAI T et al. High frequency of anti-ribosomal P antibody in patients with systemic lupus erythematosus-associated hepatitis[J]. Hepatol Res, 2004, 28 (3): 137- 139
doi: 10.1016/j.hepres.2003.11.008
33 GOLDBERG A C , BITTENCOURT P L , OLIVEIRA L C et al. Autoimmune hepatitis in Brazil:an overview[J]. Scand J Immunol, 2007, 66 (2-3): 208- 216
doi: 10.1111/sji.2007.66.issue-2-3
34 SHOR D B , DAHAN S , COMANESHTER D et al. Does inflammatory bowel disease coexist with systemic lupus erythematosus?[J]. Autoimmun Rev, 2016, 15 (11): 1034- 1037
doi: 10.1016/j.autrev.2016.07.027
35 KASER A , ZEISSIG S , BLUMBERG R S . Inflammatory bowel disease[J]. Annu Rev Immunol, 2010, 28 573- 621
doi: 10.1146/annurev-immunol-030409-101225
36 KATSANOS K H , VOULGARI P V , TSIANOSE V . Inflammatory bowel disease and lupus:a systematic review of the literature[J]. J Crohns Colitis, 2012, 6 (7): 735- 742
doi: 10.1016/j.crohns.2012.03.005
37 DE JAGER P L , GRAHAM R , FARWELL L et al. The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus[J]. Genes Immun, 2006, 7 (4): 327- 334
doi: 10.1038/sj.gene.6364303
38 FERREIROS-VIDAL I , GARCIA-MEIJIDE J , CARREIRA P et al. The three most common CARD15 mutations associated with Crohn's disease and the chromosome 16 susceptibility locus for systemic lupus erythematosus[J]. Rheumatology(Oxford), 2003, 42 (4): 570- 574
doi: 10.1093/rheumatology/keg192
39 NITZAN O , ELIAS M , SALIBAW R . Systemic lupus erythematosus and inflammatory bowel disease[J]. Eur J Intern Med, 2006, 17 (5): 313- 318
doi: 10.1016/j.ejim.2006.02.001
40 BERNSTEIN C N , BLANCHARD J F , RAWSTHORNE P et al. The prevalence of extraintestinal diseases in inflammatory bowel disease:a population-based study[J]. Am J Gastroenterol, 2001, 96 (4): 1116- 1122
doi: 10.1111/j.1572-0241.2001.03756.x
41 RICART E , PANACCIONE R , LOFTUS E V et al. Autoimmune disorders and extraintestinal manifestations in first-degree familial and sporadic inflammatory bowel disease:a case-control study[J]. Inflamm Bowel Dis, 2004, 10 (3): 207- 214
doi: 10.1097/00054725-200405000-00005
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