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浙江大学学报（医学版）
浙江大学学报（医学版）  2018, Vol. 47 Issue (4): 419-425    DOI: 10.3785/j.issn.1008-9292.2018.08.15
综述     
氧化应激在子宫内膜异位症发病机制中的研究进展
何佳怡(),张信美*()
浙江大学医学院附属妇产科医院, 浙江 杭州 310006
Research progress on oxidative stress in pathogenesis of endometriosis
HE Jiayi(),ZHANG Xinmei*()
Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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摘要：

近年来大量研究表明，子宫内膜异位症患者体内普遍存在氧化应激现象。线粒体呼吸链异常、雌激素代谢失衡、内环境铁过载和子宫内膜异位病灶可导致活性氧增多，抗氧化酶和非酶类物质减少导致患者体内抗氧化水平减弱，而环境因素则会加剧子宫内膜异位症患者的氧化抗氧化失衡。本文从氧化物过度产生和抗氧化能力下降两方面分析氧化应激及其在子宫内膜异位症发病中的作用，旨在为发现子宫内膜异位症新的治疗方案提供思路。
关键词： 子宫内膜异位症;  氧化性应激;  活性氧;  雌激素类;  线粒体;  电子转运;  综述    
Abstract:

A large number of studies have shown that the oxidative imbalance is common in patients with endometriosis. Abnormal respiratory chain of mitochondrial, estrogen metabolism imbalance, iron overload, and ectopic foci may increase active oxygen, reduction of antioxidant enzyme and non-enzymatic substances may result in decreased antioxidant level, and the exposure to environmental hazards may further aggravate oxidative imbalance in patients with endometriosis. This article analyzes the oxidative imbalance and its role in the pathogenesis of endometriosis from the aspects of excessive oxide production and decreased antioxidant capacity.
Key words: Endometriosis    Oxidative stress    Reactive oxygen species    Estrogens    Mitochondria    Electron transport    Review
收稿日期: 2018-01-22 出版日期: 2018-12-04
:  R711.71  
基金资助: “十三五”国家重点研发计划(2017YFC1001202);国家自然科学基金(81471433, 81671429)
通讯作者: 张信美     E-mail: 21718425@zju.edu.cn;zhangxinm@zju.edu.cn
作者简介: 何佳怡(1993-), 女, 硕士研究生, 主要从事子宫内膜异位症研究; E-mail:21718425@zju.edu.cn; https://orcid.org/0000-0001-7228-2228
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引用本文:

何佳怡,张信美. 氧化应激在子宫内膜异位症发病机制中的研究进展[J]. 浙江大学学报（医学版）, 2018, 47(4): 419-425.

HE Jiayi,ZHANG Xinmei. Research progress on oxidative stress in pathogenesis of endometriosis. J Zhejiang Univ (Med Sci), 2018, 47(4): 419-425.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2018.08.15    或    http://www.zjujournals.com/med/CN/Y2018/V47/I4/419

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