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浙江大学学报（医学版）
浙江大学学报（医学版）  2018, Vol. 47 Issue (4): 413-418    DOI: 10.3785/j.issn.1008-9292.2018.08.14
综述     
维生素D在子宫内膜异位症中的作用研究进展
张丽凤(),张信美*()
浙江大学医学院附属妇产科医院, 浙江 杭州 310006
Research progress on roles of vitamin D in endometriosis
ZHANG Lifeng(),ZHANG Xinmei*()
Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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摘要：

维生素D除了调节机体钙磷代谢维持骨骼强壮外，还具有免疫调节、抗炎等作用，与慢性炎症性疾病、免疫疾病、肿瘤等有关。近年研究发现，维生素D可通过调节免疫、炎症反应、细胞增殖及凋亡、血管生成、细胞黏附及侵袭等方面参与子宫内膜异位症的发病；补充维生素D可缓解子宫内膜异位症相关疼痛，改善内膜容受性，防治子宫内膜异位症。本文就近年来维生素D在子宫内膜异位症中的作用及机制研究进展作一综述。
关键词： 子宫内膜异位症;  维生素D;  免疫活性;  综述    
Abstract:

In addition to regulating calcium and phosphorus metabolism to maintain strong bones, vitamin D also has immune regulating and anti-inflammatory effects. Moreover, it is related to chronic inflammatory diseases, autoimmune diseases and cancer. Many studies indicate the roles of vitamin D in the development and progression of endometriosis including the effects on modulation of immune responses, inflammation reactions, cell proliferation and apoptosis, angiogenesis, adhesion and invasion. Vitamin D supplementation can relieve pain and improve endometrial receptivity associated with endometriosis and play a preventive and therapeutic role. This paper summarizes the roles of vitamin D in endometriosis.
Key words: Endometriosis    Vitamin D    Immunocompetence    Review
收稿日期: 2018-06-20 出版日期: 2018-12-04
:  R711.71  
基金资助: 国家自然科学基金(81471433, 81671429)
通讯作者: 张信美     E-mail: lfzhang1993@163.com;zhangxinm@zju.edu.cn
作者简介: 张丽凤(1993-), 女, 硕士研究生, 主要从事子宫内膜异位症研究; E-mail:lfzhang1993@163.com; https://orcid.org/0000-0002-1414-4043
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引用本文:

张丽凤,张信美. 维生素D在子宫内膜异位症中的作用研究进展[J]. 浙江大学学报（医学版）, 2018, 47(4): 413-418.

ZHANG Lifeng,ZHANG Xinmei. Research progress on roles of vitamin D in endometriosis. J Zhejiang Univ (Med Sci), 2018, 47(4): 413-418.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2018.08.14    或    http://www.zjujournals.com/med/CN/Y2018/V47/I4/413

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