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浙江大学学报（医学版）
浙江大学学报（医学版）  2017, Vol. 46 Issue (5): 505-510    DOI: 10.3785/j.issn.1008-9292.2017.10.09
精准影像医学专题     
动态增强磁共振成像参照物模型定量参数与乳腺癌预后因素及分子病理分型的关系
李爱静1, 潘宇宁2, 陈斌1, 夏建笔1, 干放1, 金银华1, 郑建军1
1. 宁波市第二医院放射科, 浙江 宁波 315010;
2. 宁波市第一医院放射科, 浙江 宁波 315010
Association of parameters in dynamic contrast-enhanced MRI using reference region model with prognostic factors and molecular subtypes of breast cancer
LI Aijing1, PAN Yuning2, CHEN Bin1, XIA Jianbi1, GAN Fang1, JIN Yinhua1, ZHENG Jianjun1
1. Department of Radiology, Ningbo Second Hospital, Ningbo 315010, Zhejiang Province, China;
2. Department of Radiology, Ningbo First Hospital, Ningbo 315010, Zhejiang Province, China
 全文: PDF(999 KB)  
摘要：

目的：评估动态增强磁共振成像（DCE-MRI）参照物模型定量参数与乳腺浸润性导管癌患者预后相关因素和乳腺癌分子病理分型之间的相关性。方法：回顾性分析50例经病理学检查证实的浸润性导管癌患者的MRI和病理学检查资料，运用DCE-MRI参照物模型测量药代动力学定量参数，包括病灶相对肌肉的容量转运常数（RR Ktrans）、病灶的速率常数（Kep）、病灶的容量转运常数与肌肉的血管外细胞外间隙容积比值（Ktrans/Ve），分析上述定量参数与乳腺癌患者预后相关因素和乳腺癌分子病理分型之间的相关性。结果：组织学分级为3级的病灶的平均RR Ktrans和Kep值高于组织分级为1~2级的病灶（均P<0.05）；雌激素受体（ER）阴性者和孕激素受体（PR）阴性者的平均RR Ktrans值和Kep值分别高于ER阳性者和PR阳性者（均P<0.05）。三阴性乳腺癌患者的RR Ktrans和Kep高于Luminal型乳腺癌患者（均P<0.05）。结论：DCE-MRI参照物模型所得定量参数RR Ktrans和Kep有助于预测乳腺癌的预后和鉴别乳腺癌的分子病理分型。
关键词： 乳腺肿瘤/诊断;  钆/诊断应用;  预后;  模型;  生物学;  血流动力学;  回顾性研究;  磁共振成像/方法    
Abstract:

Objective: To investigate the association of parameters in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using reference region model with prognostic factors and molecular subtypes of breast cancer.Methods: MRI and pathological data of 50 patients with pathologically confirmed invasive ductal carcinoma of the breast were retrospectively analyzed. Reference region model was applied to analyze pharmacokinetic quantitative parameters including volume transfer constant (RR Ktrans), rate constant (Kep) and the ratio of Ktrans to extracellular space volume (Ktrans/Ve). The associations of the above parameters with prognostic factors and molecular subtypes of breast cancer were analyzed.Results: RR Ktrans and Kep were significantly higher in patients of histological grade 3 compared with those of histological grade 1 & 2 (all P<0.05); and the patients with estrogen receptor (ER)-negative and/or progesterone receptor (PR)-negative also had higher RR Ktrans and Kep than those with ER-positive or PR-positive (all P<0.05). For immunohistochemistry, RR Ktrans and Kep were significantly higher in triple negative breast cancer compared with luminal type breast cancer (all P<0.05).Conclusion: High RR Ktrans and Kep are associated with poor prognosis of breast cancer, and which can also be used to distinguish molecular subtypes of breast cancer.
Key words: Magnetic resonance imaging/methods    Gadolinium/diagnostic use    Prognosis    Retrospective studies    Breast neoplasms/diagnosis    Models,biological    Hemodynamics
收稿日期: 2017-04-19 出版日期: 2017-10-25
CLC:  R445.2  
基金资助:

宁波市自然科学基金（2016A610140）；宁波市科技惠民科技项目（2016C51013）；浙江省公益技术应用研究计划（2017C35003）；宁波市社发领域重大科技专项（2015C50004）；浙江省医药卫生重大科技计划（WKJ-ZJ-1807）
通讯作者: 郑建军(1973-),男,大学,主任医师,硕士生导师,主要从事肿瘤分子影像学及其新材料研究;E-mail:zhjjnb2@163.com;http://orcid.org/0000-0002-6177-9607     E-mail: zhjjnb2@163.com
作者简介: 李爱静(1980-),女,硕士,副主任医师,主要从事乳腺、头颈部影像诊断及新技术应用研究;E-mail:lajnbey@163.com;http://orcid.org/0000-0001-8854-3541
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引用本文:

李爱静 等. 动态增强磁共振成像参照物模型定量参数与乳腺癌预后因素及分子病理分型的关系[J]. 浙江大学学报（医学版）, 2017, 46(5): 505-510.

LI Aijing, PAN Yuning, CHEN Bin, XIA Jianbi, GAN Fang, JIN Yinhua, ZHENG Jianjun. Association of parameters in dynamic contrast-enhanced MRI using reference region model with prognostic factors and molecular subtypes of breast cancer. Journal of ZheJiang University(Medical Science), 2017, 46(5): 505-510.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2017.10.09    或    http://www.zjujournals.com/xueshu/med/CN/Y2017/V46/I5/505

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