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浙江大学学报(医学版)  2017, Vol. 46 Issue (3): 328-333    DOI: 10.3785/j.issn.1008-9292.2017.06.17
综述     
肽类激素Kisspeptin在生殖内分泌领域的应用前景
傅燕玲, 朱依敏
浙江大学医学院附属妇产科医院生殖内分泌科, 浙江 杭州 310006
Potential clinical application of Kisspeptin in reproductive endocrinology
FU Yanling, ZHU Yimin
Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
 全文: PDF(979 KB)  
摘要:

肽类激素Kisspeptin是调控女性生殖内分泌功能的重要激素,能作用于促性腺激素释放激素(GnRH)神经元,刺激GnRH分泌,从而激活下丘脑-垂体-性腺轴。在大量动物实验的基础上,越来越多的人体临床实验结果表明,外源性地给予Kisspeptin能够使健康个体甚至生殖内分泌紊乱的个体诱发生理性GnRH释放。Kisspeptin在诱导女性排卵及卵子成熟方面可能较传统药物更贴近生理过程,更具安全性和高效性,在体外受精治疗中有一定程度的优势。同时,Kisspeptin因其与滋养细胞浸润相关,可能用于预测妊娠结局。另外,Kisspeptin是启动青春期的关键激素,在人体代谢和生殖功能方面起到了信号传导作用,这为多囊卵巢综合征、高泌乳素血症等相关生殖内分泌疾病的诊治提示了新的研究思路。本文综述Kisspeptin在生殖内分泌领域的应用前景。

关键词: 肽类激素/药理学促性腺素释放激素/分泌生殖内分泌系统疾病受精体外综述    
Abstract:

Gonadotropin-releasing hormone (GnRH) plays an important role in the process of reproduction. Studies have shown that a family of peptides Kisspeptin can act on GnRH-related neurons, stimulating the secretion of GnRH, and activating the hypothalamic-pituitary-gonadal axis. Both animal experiments and clinical studies have shown that exogenous administration of Kisspeptin is able to induce physiological GnRH release in healthy individuals and those with endocrine-disorders, which brings great hope for treatment of reproductive endocrine diseases. The effect of Kisspeptin is similar to the physiological process in induction of ovulation and ovum maturation, leading to high security and efficiency for women receiving in vitro fertilization. Kisspeptin is involved in trophoblast invasion, so it may be useful for predicting pregnancy outcomes. In addition, Kisspeptin is the key hormone in the onset of puberty acting as a signal transducer in metabolism and reproduction, so it provides some directions for studies of polycystic ovary syndrome, hyperprolactinemia, and other metabolic-related reproductive endocrine diseases. This article reviews the character of Kisspeptin and the prospect of its application in treatment of reproductive endocrine diseases.

Key words: Peptide hormones/pharmacology    Gonadotropin-releasing hormone/secretion    Reproduction    Endocrine system diseases    Fertilization in vitro    Review
收稿日期: 2017-06-01 出版日期: 2017-06-25
CLC:  R714  
基金资助:

国家科技支撑计划(2014BAI05B04)

通讯作者: 朱依敏(1964-),女,博士,主任医师,博士生导师,主要从事生殖内分泌学研究;E-mail:zhuyim@zju.edu.cn     E-mail: zhuyim@zju.edu.cn
作者简介: 傅燕玲(1992-),女,硕士研究生,主要从事生殖内分泌学研究;E-mail:maggiefu0113@163.com
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引用本文:

傅燕玲 等. 肽类激素Kisspeptin在生殖内分泌领域的应用前景[J]. 浙江大学学报(医学版), 2017, 46(3): 328-333.

FU Yanling, ZHU Yimin. Potential clinical application of Kisspeptin in reproductive endocrinology. Journal of ZheJiang University(Medical Science), 2017, 46(3): 328-333.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2017.06.17        http://www.zjujournals.com/xueshu/med/CN/Y2017/V46/I3/328

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