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浙江大学学报（医学版）
浙江大学学报（医学版）  2017, Vol. 46 Issue (2): 167-172    DOI: 10.3785/j.issn.1008-9292.2017.04.08
专题报道     
纳米材料靶向肿瘤相关巨噬细胞用于肿瘤成像及治疗的研究进展
郭峰亮1(),汤谷平2,*(),胡青莲1
1. 浙江工业大学生物工程学院, 浙江 杭州 310032
2. 浙江大学有机与药物化学研究所, 浙江 杭州 310028
Advances in nanoparticle-targeting tumor associated macrophages for cancer imaging and therapy
GUO Fengliang1(),TANG Guping2,*(),HU Qinglian1
1. College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China
2. Institute of Organic and Medicinal Chemistry, Zhejiang University, Hangzhou 310028, China
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摘要：

肿瘤组织由肿瘤细胞和复杂的微环境构成。肿瘤相关巨噬细胞（TAM）是肿瘤微环境的重要组成成分，在肿瘤生长转移及微环境调控中扮演着重要的角色。近年来的研究表明，纳米材料作为新兴的技术平台，为肿瘤的成像和治疗提供了新的思路。一方面可以通过TAM成像为肿瘤发生、发展以及肿瘤治疗的效果提供直观的证据；另一方面通过TAM靶向杀伤或者促进TAM类型转化，调节肿瘤微环境的免疫抑制，提高肿瘤治疗效果。本文阐述了TAM的功能，同时对靶向TAM的纳米材料在肿瘤成像以及治疗方面的应用进行了综述。
关键词： 巨噬细胞/生理学;  肿瘤/免疫学;  肿瘤/诊断，肿瘤/治疗;  纳米结构;  免疫疗法;  综述    
Abstract:

Tumor tissues are composed of tumor cells and complicate microenvironment. Tumor associated macrophages (TAMs) as an important component in tumor microenvironment, play fundamental roles in tumor progression, metastasis and microenvironment regulation. Recently, studies have found that nanotechnology, as an emerging platform, provides unique potential for cancer imaging and therapy. With the nanotechnology, TAMs imaging presents direct evidence for cancer development, progression, and the effectiveness of cancer treatments; it also can regulate the immunosuppression of tumor microenvironment and improve therapeutic efficiency through TAMs targeted killing or phenotypic transformation. In this article, we illustrate the function of TAMs and review the latest development in nano-carriers and their applications in tumor associated macrophage targeting cancer imaging and therapy.
Key words: Macrophages/physiology    Neoplasms/immunology    Neoplasms/diagnosis    Neoplasms/therapy    Nanostructures    Immunotherapy    Review
收稿日期: 2016-12-23 出版日期: 2017-08-07
基金资助: 国家自然科学基金（51603186）
通讯作者: 汤谷平     E-mail: 374095668@qq.com;tangguping@zju.edu.cn
作者简介: 郭峰亮(1991—)，男，硕士研究生，主要从事纳米材料与免疫系统相互作用研究；E-mail: 374095668@qq.com；http://orcid.org/0000-0003-1874-4326
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引用本文:

郭峰亮,汤谷平,胡青莲. 纳米材料靶向肿瘤相关巨噬细胞用于肿瘤成像及治疗的研究进展[J]. 浙江大学学报（医学版）, 2017, 46(2): 167-172.

GUO Fengliang,TANG Guping,HU Qinglian. Advances in nanoparticle-targeting tumor associated macrophages for cancer imaging and therapy. J Zhejiang Univ (Med Sci), 2017, 46(2): 167-172.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2017.04.08    或    http://www.zjujournals.com/xueshu/med/CN/Y2017/V46/I2/167

图 1  纳米材料靶向肿瘤相关巨噬细胞应用于肿瘤成像(A)和肿瘤免疫治疗(B)的示意图
图 2  肿瘤相关巨噬细胞在肿瘤发展过程中分泌的主要细胞因子[3]
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