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浙江大学学报（医学版）
浙江大学学报（医学版）  2017, Vol. 46 Issue (1): 80-88    DOI: 10.3785/j.issn.1008-9292.2017.02.12
中药现代化     
近红外光谱应用于中药质量控制及生产过程监控的研究进展
李文龙(),瞿海斌()
浙江大学药物信息学研究所, 杭州 310058
Application progress on near infrared spectroscopy in quality control and process monitoring of traditional Chinese medicine
LI Wenlong(),QU Haibin()
Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China
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摘要：

目前中药生产过程存在原料质量波动较大、制药过程模糊等问题。近红外光谱分析技术具有信息丰富、分析快速、样品无损等特点，近年来已成功运用于中药材、中间体、中成药等定量分析，中药的真α 、基源、产地、生产厂家等鉴别，以及中药提取、醇沉、柱层析、混料等生产过程的监控。本文对近红外光谱分析技术在中药领域的应用进行综述，并针对其应用中缺乏必要的标准等问题，提出结合中药具体特点来开展近红外光谱分析技术的规范化研究，以期推动该技术在中药行业更为广泛的应用。
关键词： 谱学, 近红外线;  中药鉴定/方法;  质量控制;  中草药/分析;  药物监测;  综述    
Abstract:

The industry of traditional Chinese medicine (TCM) encounters problems like quality fluctuation of raw materials and unstandardized production process. Near infrared (NIR) spectroscopy technology is widely used in quality control of TCM because of its abundant information, fast and nondestructive characters. The main applications include quantitative analysis of Chinese medicinal materials, intermediates and Chinese patent medicines; the authenticity of TCM, species, origins and manufacturers; monitoring and control of the extraction, alcohol precipitation, column chromatography and blending process. This article reviews the progress on the application of NIR spectroscopy technology in TCM field. In view of the problems existing in the application, the article proposes that the standardization of NIR analysis method should be developed according to specific characteristics of TCM, which will promote the application of NIR technology in the TCM industry.
Key words: Spectroscopy, near-infrared    TCD IDENTIFICATION/methods    Quality control    Drugs, Chinese herbal/analysis    Drug monitoring    Review
收稿日期: 2016-12-20 出版日期: 2017-07-06
CLC:  R917  
基金资助: 浙江省自然科学基金(LY17H280001);浙江省中医药科学研究基金(2015ZB023)
通讯作者: 瞿海斌     E-mail: wshlwl@zju.edu.cn;quhb@zju.edu.cn
作者简介: 李文龙 (1980-), 男, 博士, 讲师, 主要从事中药质量控制技术研究; E-mail:wshlwl@zju.edu.cn|瞿海斌 (1969-), 男, 博士, 教授, 博士生导师, 主要从事中药制药工艺及过程分析技术研究; E-mail: quhb@zju.edu.cn
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引用本文:

李文龙,瞿海斌. 近红外光谱应用于中药质量控制及生产过程监控的研究进展[J]. 浙江大学学报（医学版）, 2017, 46(1): 80-88.

LI Wenlong,QU Haibin. Application progress on near infrared spectroscopy in quality control and process monitoring of traditional Chinese medicine. J Zhejiang Univ (Med Sci), 2017, 46(1): 80-88.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2017.02.12    或    http://www.zjujournals.com/med/CN/Y2017/V46/I1/80

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