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浙江大学学报(医学版)  2016, Vol. 45 Issue (6): 626-630    DOI: 10.3785/j.issn.1008-9292.2016.11.11
原著     
长期电离辐射对介入放射人员造血系统和细胞遗传学的影响
周齐红, 俞慧娟, 付风云, 叶海朋
杭州市职业病防治院检验科, 浙江 杭州 310014
Assessment of hematopoiesis and cytogenetics changes in interventional radiologists
ZHOU Qihong, YU Huijuan, FU Fengyun, YE Haipeng
Hangzhou Prevention and Treatment Center for Occupational Diseases, Hangzhou 310014, China
 全文: PDF(1013 KB)  
摘要:

目的:了解长期从事介入放射工作人员的造血功能和细胞遗传学情况。方法:对介入放射人员121名、普通放射人员245名及无射线接触的其他医务人员100名进行淋巴细胞染色体畸变分析与微核率检测,同时分析白细胞检测结果。结果:血常规检查结果显示,介入放射组白细胞计数、中性粒细胞比例降低,淋巴细胞比例升高,与普通放射组和对照组间差异具有统计学意义(均P<0.05)。介入放射组染色体畸变率高于对照组和普通放射组(均P<0.05),染色体畸变主要为双着丝粒体、无着丝粒环、断片和微小体。微核率检测结果显示,介入放射组的微核率高于对照组和普通放射组,差异有统计学意义(P<0.05或P<0.01)。介入放射人员染色体畸变率和微核率异常比例随着工龄的增加而增加,但不同工龄间差异无统计学意义(P>0.05)。结论:长期接触电离辐射可导致人体造血系统变化和人体染色体损伤,这种异常的程度可能与接触电离辐射的剂量有关。

关键词: 辐射电离淋巴细胞/病理学微核试验染色体/辐射效应白细胞/辐射效应放射学介入性/人力    
Abstract:

Objective: To investigate hematopoiesis and cytogenetics changes in staff of interventional radiology. Methods: A total of 121 intervention radiation workers, 245 common radiation workers and 100 medical personnel (healthy control) without exposure to radiation were enrolled in the study. The peripheral lymphocyte chromosomal aberrations and micronucleus were detected, and the result of white blood cells examination was analyzed. Results: Compared with common radiation group and healthy control group, decreases in white blood cells count, neutrophil ratio, and increase in lymphocyte ratio were observed in intervention radiation group (all P<0.05). Intervention radiation group had higher chromosome aberration rate and micronuclear rate than common radiation group and healthy control group (all P<0.05). Most common chromosome aberrations were dicentric chromosome, acentric ring, fragments and minute chromosome. Abnormal rates in chromosome aberration and micronucleus rates were increased with the rise of length of service, but no statistically significant difference was observed (P>0.05). Conclusion: Long term exposure to ionizing radiation may lead to changes in the human hematopoietic system and cause human chromosome aberration, and the severity of such injuries may be associated with the dose of ionizing radiation.

Key words: Radiation, ionizing    Lymphocytes/pathology    Micronucleus tests    Chromosomes/radiation effects    Leukocytes/radiation effects    Radiology, interventional/manpower
收稿日期: 2016-01-24
CLC:  R81  
基金资助:

浙江省医药卫生科技计划(2016KYB241)

作者简介: 周齐红(1976-),女,学士,主管技师,主要从事临床检验工作;E-mail:122347594@qq.com;http://orcid.org/0000-0002-2148-9277
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引用本文:

周齐红 等. 长期电离辐射对介入放射人员造血系统和细胞遗传学的影响[J]. 浙江大学学报(医学版), 2016, 45(6): 626-630.

ZHOU Qihong, YU Huijuan, FU Fengyun, YE Haipeng. Assessment of hematopoiesis and cytogenetics changes in interventional radiologists. Journal of ZheJiang University(Medical Science), 2016, 45(6): 626-630.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.11.11        http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I6/626

[1] LABERGE J M, ANDERSON J C. A guide to the interventional radiology residency program requirements[J]. J Am Coll Radiol, 2015, 12(8):848-53.
[2] SÁNCHEZ R M, VANO E, FERNÁNDEZ J M, et al. Staff doses in interventional radiology:a national survey[J]. J Vasc Interv Radiol, 2012, 23(11):1496-501.
[3] KUNT H, DAYIO?LU H, ÇAYCI M K, et al. The assessment as bone mineral density of bone damage in radiology workers occupationally exposed to ionizing radiation[J]. Eur J Gen Med, 2013, 10(4):214-218.
[4] OSKOUII M R, REFAHI S, POURISSA M, et al. Assessment of humoral immunity in workers occupationally exposed to low levels of ionizing radiation[J]. Studi Italiani Di Linguistica Teorica Ed Applicata, 2013, 49(5):1005-1009.
[5] 刘成玉,罗春丽. 临床检验基础[M].5版. 北京:人民卫生出版社,2013:7-8,49. LIU Chengyu, LUO Chunli. Basis of clinical laboratory[M]. 5th ed. Beijing:People's Health Publishing House, 2013:7-8, 49. (in Chinese)
[6] 中华人民共和国国家卫生和计划生育委员会. GBZ/T248-2014放射工作人员职业健康检查外周血淋巴细胞染色体畸变检测与评价[S]. 北京:中国标准出版社,2014. National Health and Family Planning Commission of the People's Republic of China. GBZ/T248-2014 Test and assessment of chromosomal aberrations on occupational health examinations for radition workers[S]. Beijing:China Standards Publishing House, 2014.(in Chinese)
[7] 白玉书,陈德清. 人类辐射细胞遗传学[M]. 北京:人民卫生出版社,2006:105-107. BAI Yushu, CHEN Deqing. Human radiation cytogenetics[M]. Beijing:People's Health Publishing House, 2006:105-107.(in Chinese)
[8] 孙一丁,牛如芳,李敏. 从事介入治疗医护人员体细胞染色体畸变及白细胞总数的检测[J].工业卫生与职业病,2000,26(5):282-283. SUN Yiding, NIU Rufang, LI Min. Study on chromosome aberration and leukocyte count of medical staff engaging in intervention treatment[J]. Industrial Health and Occupational Diseases, 2000, 26(5):282-283. (in Chinese)
[9] 杨爱初,刘移民,杜柳涛,等. 广东省放射工作人员健康状况调查[J].中国职业医学,2003,30(4):22. YANG Aichu, LIU Yimin, DU Liutao, et al. Investigation on health status of radiation-exposed workers in Guangdong province[J]. China Occupational Medicine, 2003, 30(4):22.(in Chinese)
[10] 于夕荣,何顺升,杨珂,等. 82例介入放射学工作者剂量与效应分析[J].中华放射医学与防护杂志,1999,19(3):216-217. YU Xirong, HE Shunsheng, YANG Ke, et al. Dose effect analysis on 82 cases of interventional radiology workers[J]. Chinese Journal of Radiological Medicine and Protection, 1999, 19(3):216-217.(in Chinese)
[11] 罗文文,赵洁.消化内科医生放射暴露情况调查及健康状况分析[J].中华劳动卫生职业病杂志,2014,32(2):133-135. LUO Wenwen, ZHAO Jie. Investigation and analysis of health status on digestive physician radiation exposure situation[J]. Chinese Journal of Industrial Hygiene and Occupational Diseases, 2014, 32(2):133-135.(in Chinese)
[12] 张素英,李全开,吴旭梅,等. 放射人员白细胞、淋巴细胞微核率及染色体畸变率异常影响因素分析[J].中华放射医学与防护杂志,2010,30(1):61-62. ZHANG Suying, LI Quankai, WU Xumei, et al. Influencing factors on anomaly rate of radiation personnel leukocyte, lymphocyte micronucleus rate and chromosome aberration[J]. Chinese Journal of Radiological Medicine and Protection, 2010, 30(1):61-62.(in Chinese)
[13] 李清芹,刘永兰,游江成,等. 电离辐射对放射工作人员外周血淋巴细胞染色体畸变率的影响[J].福建医药杂志,2014,35(4):60-62. LI Qingqin, LIU Yonglan, YOU Jiangcheng, et al. Effect on cytogenetics of stuffs exposed to radiation by occupational exposure[J]. Fujian Medical Journal, 2014, 35(4):60-62.(in Chinese)
[14] 庄丽,邱玉会,李文.济南市1999年放射工作人员个人剂量监测分析[J].中国辐射卫生,2001,10(2):108. ZHUANG Li, QIU Yuhui, LI Wen. Personal dose monitoring of radiation workers in Jinan in 1999[J]. Chinese Journal of Radiological Health, 2001, 10(2):108.(in Chinese)
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