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浙江大学学报（医学版）
浙江大学学报（医学版）  2016, Vol. 45 Issue (3): 315-322    DOI: 10.3785/j.issn.1008-9292.2016.05.16
综述     
秀丽隐杆线虫神经胶质细胞对神经系统发育和功能的影响
徐玉兰, 薛雅丹, 康利军
浙江大学医学院神经科学研究所, 浙江 杭州 310058
The effect of glial cells in the function and development of the nervous system in Caenorhabditis elegans
XU Yulan, XUE Yadan, KANG Lijun
Institute of Neuroscience, Zhengjiang University School of Medicine, Hangzhou 310058, China
全文: PDF(1095 KB)  
摘要: 

秀丽隐杆线虫（简称线虫）神经胶质细胞（简称胶质细胞）分为三种类型：鞘状胶质细胞、槽状胶质细胞和谷氨酸受体胶质细胞，主要分布在化学感受器、头部感受器、外唇感受器和内唇感受器这四种感觉器官中。在神经系统发育过程中，胶质细胞在线虫神经元的树突延伸和轴突的导向延伸中发挥关键作用，还参与了突触生成，并且通过形成感受器通道的方式来维持感觉神经末梢的正常形态和功能。此外，线虫胶质细胞还可作为神经元的起源。在神经系统成熟过程中，线虫胶质细胞既可通过维持神经元形态来间接控制感觉神经元的功能，也可直接控制感觉神经元的功能。有些胶质细胞可以感受特定的外界刺激，用这些信息来调节与之相伴神经元的活动。线虫胶质细胞不仅通过神经元来影响神经系统，其自身也可以感受机械刺激。本文总结了目前已知线虫胶质细胞对神经发育和功能影响的研究进展。
关键词 ： 新小杆线虫,漂亮,  神经胶质/细胞学,  神经系统/生长和发育,  综述    
Abstract：

There are three types of glial cells in Caenorhabditis elegans (C. elegans for short): sheath glia, socket glia and glutamate receptor glia. They are mainly located in four sensory organs including the amphid, the cephalic organ, the outer labial sensilla and the inner labial sensilla. C. elegans glial cells play key roles in dendrite extension, neurite guidance and extension, and are essential for synaptogenesis and maintain the normal morphology and the function of sensory nerve endings as well. A recent study shown that some nematode neurons are derived from the glial cells. Moreover, nematodes glial cells can directly modulate the function of sensory neurons. Some glial cells can also respond to certain external stimuli, such as mechanical stimulation, and adjust the accompanying neuronal activities.The article summarizes the progress on effects of nematodes glial cells on the nervous system development and function.
Key words： Caenorhabditis elegans    Neuroglia/cytology    Nervous system/growth&    development    Review
收稿日期: 2015-11-10
CLC:  Q421  
基金资助:

国家重大科学研究计划（2013CB945603）；国家高技术研究发展计划（863计划）（2015AA020512）；国家自然科学基金（31471023，31271180）；浙江省自然科学基金杰出青年项目（LR14C090001）
通讯作者: 康利军(1973-),男,博士,研究员,博士生导师,主要从事机械敏感离子通道和神经胶质细胞的生理、病理和药理研究;E-mail:kanglijun@zju.edu.cn;http://orcid.org/0000-0001-9939-5134     E-mail: kanglijun@zju.edu.cn
作者简介: 徐玉兰(1990-),女,硕士研究生,主要从事神经胶质细胞参与神经调控的分子与细胞机制研究;E-mail:1138688311@qq.com;http://orcid.org/0000-0002-0386-2875
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引用本文:

徐玉兰 等. 秀丽隐杆线虫神经胶质细胞对神经系统发育和功能的影响[J]. 浙江大学学报（医学版）, 2016, 45(3): 315-322.
XU Yulan, XUE Yadan, KANG Lijun. The effect of glial cells in the function and development of the nervous system in Caenorhabditis elegans. Journal of ZheJiang University(Medical Science), 2016, 45(3): 315-322.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.05.16      或      http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I3/315

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