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浙江大学学报（医学版）
浙江大学学报（医学版）  2016, Vol. 45 Issue (3): 302-307    DOI: 10.3785/j.issn.1008-9292.2016.05.14
综述     
Toll样受体在抗白假丝酵母菌感染中的作用研究进展
周云1,2, 潘建平1
1. 浙江大学城市学院医学院, 浙江 杭州 310015;
2. 浙江大学医学院病原生物学系, 浙江 杭州 310058
Progress on the role of Toll-like receptors in Candida albicans infections
ZHOU Yun1,2, PAN Jianping1
1. Zhejiang University City College School of Medicine, Hangzhou 310015, China;
2. Department of Pathogen Biology, Zhejiang University School of Medicine, Hangzhou 310058, China
全文: PDF(984 KB)  
摘要: 

Toll样受体（TLR）是一类主要表达于树突状细胞和巨噬细胞等固有免疫细胞上的模式识别受体，能识别和结合白假丝酵母菌上的病原相关分子模式，并引起特定下游信号转导。TLR多态性与宿主对白假丝酵母菌的易感性有关，TLR激活后可诱导促炎性细胞因子的表达，发挥抗白假丝酵母菌感染作用；而白假丝酵母菌也可发生菌相改变以利于逃逸机体免疫反应。了解TLR和白假丝酵母菌之间的相互作用，可为阐明抗真菌感染免疫的机制提供新的实验依据。
关键词 ： Toll样受体,  念珠菌,白色/药物作用,  细胞因子类,  感染/药物疗法,  综述    
Abstract：

Toll like receptors (TLRs) are expressed mainly on innate immunocytes such as dendritic cells and macrophages, and may have the potential to recognize and bind to pathogen-associated molecular patterns (PAMPs) from Candida albicans, thereby triggering the downstream signals. The genetic polymorphism of TLRs is associated with susceptibility to Candida albicans. The activation of TLRs by PAMPs from Candida albicans can induce the production of proinflammatory cytokines that play key roles in the anti-infection of Candida albicans. However, in order to evade the immune response of host,Candida albicans can also change its bacterial phase. Understanding of the interaction between TLRs and Candida albicans will provide novel evidence to further clarify the mechanisms of anti-fungal immune response.
Key words： Toll-like receptors    Candida albicans/drug effects    Cytokines    Infection/drug therapy    Review
收稿日期: 2015-11-13
CLC:  R378.2  
基金资助:

浙江省医药卫生科技计划（2013KYA149）；杭州市科技发展计划（20150633B44）；杭州市高层次留学回国人员在杭创业创新项目
通讯作者: 潘建平(1962-),男,博士,教授,博士生导师,从事免疫学研究;E-mail:jppan@zucc.edu.cn;http://orchid.org/0000-0001-9636-1561     E-mail: jppan@zucc.edu.cn
作者简介: 周云(1990-),女,硕士研究生,主要从事感染免疫学研究;E-mail:zhyun0813@163.com;http://orcid.org/0000-0001-8394-0409
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引用本文:

周云 等. Toll样受体在抗白假丝酵母菌感染中的作用研究进展[J]. 浙江大学学报（医学版）, 2016, 45(3): 302-307.
ZHOU Yun, PAN Jianping. Progress on the role of Toll-like receptors in Candida albicans infections. Journal of ZheJiang University(Medical Science), 2016, 45(3): 302-307.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.05.14      或      http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I3/302

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