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| LR-90对骨关节炎模型兔关节软骨的保护效应 |
| 黄恺1, 张建方1, 万俊明1, 陆建伟1, 高阳2 |
1. 浙江省立同德医院骨科, 浙江 杭州 310012;
2. 浙江省磐安中医院骨科, 浙江 金华 322300 |
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| Protective effect of LR-90 on articular cartilage in rabbit model of osteoarthritis |
| HUANG Kai1, ZHANG Jianfang1, WAN Junming1, LU Jianwei1, GAO Yang2 |
1. Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China;
2. Department of Orthopedics, Pan'an County TCM Hospital, Pan'an 322300, China |
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[3] SATHEESAN S, FIGAROLA J L, DABBS T, et al.Effects of a new advanced glycation inhibitor, LR-90, on mitigating arterial stiffening and improving arterial elasticity and compliance in a diabetic rat model: aortic impedance analysis[J].Br J Pharmacol, 2014, 171(12):3103-3114.
[4] FIGAROLA J L, SHANMUGAM N, NATARAJAN R, et al.Anti-inflammatory effects of the advanced glycation end product inhibitor LR-90 in human monocytes[J].Diabetes, 2007, 56(3):647-655.
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[6] ROUSSET F, NGUYEN M V, GRANGE L, et al.Heme oxygenase-1 regulates matrix metalloproteinase MMP-1 secretion and chondrocyte cell death via Nox4 NADPH oxidase activity in chondrocytes[J].PLoS One, 2013, 8(6):e66478.
[7] LAI Y, BAI X, ZHAO Y, et al.ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis[J].Ann Rheum Dis, 2014, 73(8):1575-1584.
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[9] PELLETIER J P, JOVANOVIC D, FERNANDES J C, et a1.Reduced progression of experimental osteoarthritis in vivo by selective inhibition of inducible nitric oxide synthase[J].Arthritis Rheum, 1998, 41(7):1275-1286.
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[11] LAVERTY S, GIRARD C A, WILLIAMS J M, et al.The OARSI histopathology initiative-recommendations for histological assessments of osteoarthritis in the rabbit[J].Osteoarthritis Cartilage, 2010, 18(Suppl 3):S53-S65.
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[13] ZENG C, GAO S G, LEI G H.Viscosupplementation for osteoarthritis of the knee[J].N Engl J Med, 2015, 372(26):2569-2570.
[14] NEUHOLD L A, KILLAR L, ZHAO W, et al.Postnatal expression in hyaline cartilage of constitutively active human collagenase-3(MMP-13) induces osteoarthritis in mice[J].J Clin Invest, 2001, 107(1):35-44.
[15] ECHTERMEYER F, BERTRAND J, DREIER R, et al.Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis[J].Nat Med, 2009, 15(9):1072-1076.
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[17] LI N G, SHI Z H, TANG Y P, et al.New hope for the treatment of osteoarthritis through selective inhibition of MMP-13[J].Curr Med Chem, 2011, 18(7):977-1001.
[18] JABERI F M.Osteochondritis dissecans of the weight-bearing surface of the medial femoral condyle in adults[J].Knee, 2002, 9(3):201-207.
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[20] KATO T, MIYAKI S, ISHITOBI H, et al.Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes[J].Arthritis Res Ther, 2014, 16(4):R163. |
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