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浙江大学学报（医学版）
浙江大学学报（医学版）  2016, Vol. 45 Issue (2): 179-186    DOI: 10.3785/j.issn.1008-9292.2016.03.11
运动系统再生医学专题     
血小板富集血浆治疗肌腱病的研究进展
郑泽峰1,2, 乐辉辉1,2, 陈维善2, 沈炜亮1,2, 欧阳宏伟1
1. 浙江大学医学院干细胞与再生医学系 浙江大学李达三·叶耀珍干细胞与再生医学研究中心 浙江省组织工程与再生医学技术重点实验室, 浙江 杭州 310058;
2. 浙江大学医学院附属第二医院骨科 浙江大学骨科研究所, 浙江 杭州 310009
Progress on treatment of tendinopathy with platelet-enriched plasma
ZHENG Zefeng1,2, LE Huihui1,2, CHEN Weishan2, SHEN Weiliang1,2, OUYANG Hongwei1
1. Center of Stem Cell and Tissue Engineering, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Key Laboratory of Stem Cell of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China;
2. Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Orthopedics Research Institute of Zhejiang University, Hangzhou 310009, China
全文: PDF(989 KB)  
摘要: 

血小板富集血浆(PRP)是血小板浓度高于体内正常浓度且富含各种生长因子的血浆制品,通过全血离心去除红细胞后获得。PRP通过释放丰富的细胞因子,促进肌腱细胞及肌腱干细胞增殖、分化及基质的合成分泌,从而促进组织修复和再生。同时,通过抑制疼痛相关因子的表达,缓解患者的疼痛症状。目前大量临床研究表明,PRP对于髌腱病、肱骨外上髁炎、足底筋膜炎等肌腱疾病有着较好的修复作用,但也有一些研究显示其效果不确切,主要是由于PRP提取流程不一致、患者病程不同以及注射方案不同等所导致。因其安全,可作为肌腱病保守治疗的选择,尤其是在其他保守治疗无效的情况。相信通过更多严谨的基础研究及临床试验,规范其使用过程,PRP将在肌腱病的治疗上发挥更重要的作用。
关键词 ： 肌腱病,  血小板,  综述    
Abstract：

Platelet-enriched plasma (PRP) contains high concentration of platelets and abundant growth factors, which is made by centrifuging of blood and separating of blood elements. PRP promotes tendon repair by releasing various cytokines to enhance cell proliferation, tenogenic differentiation, formation and secretion of matrix; meantime, it can reduce pain by inhibiting the expression of pain-associated molecules. A number of clinical studies demonstrated that PRP was effective in treatment of tendinopathy, including patellar tendinopathy, lateral epicondylitis and plantar fasciopathy. However, some studies did not support this conclusion, because of disparity of PRP types, therapeutic courses and injections protocols in clinical application. Based on its safety, PRP can be a choice of treatment for tendinopathy, in case other non-surgical therapies are of no effect.
Key words： Tendinopathy    Blood platelets    Review
收稿日期: 2015-10-12     
CLC:  R686  
基金资助:

国家自然科学基金(81572157,81271970);浙江省自然科学基金(LY14H060003)
通讯作者: 欧阳宏伟(1971-),男,博士,教授,博士生导师,从事干细胞与组织工程的研究;E-mail:hwoy@zju.edu.cn;沈炜亮(1982-),男,博士,主治医师,硕士生导师,从事骨科疾病研究;E-mail:shenweiliang365@163.com     E-mail: hwoy@zju.edu.cn;shenweiliang365@163.com
作者简介: 郑泽峰(1991-),男,硕士研究生,从事骨科相关疾病新技术研究;E-mail:zhengzftianwang@sina.com
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引用本文:

郑泽峰 等. 血小板富集血浆治疗肌腱病的研究进展[J]. 浙江大学学报（医学版）, 2016, 45(2): 179-186.
ZHENG Zefeng, LE Huihui, CHEN Weishan, SHEN Weiliang, OUYANG Hongwei. Progress on treatment of tendinopathy with platelet-enriched plasma. Journal of ZheJiang University(Medical Science), 2016, 45(2): 179-186.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.03.11      或      http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I2/179

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