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浙江大学学报（医学版）
浙江大学学报（医学版）  2016, Vol. 45 Issue (2): 161-169    DOI: 10.3785/j.issn.1008-9292.2016.03.09
运动系统再生医学专题     
碳纳米管在骨组织工程支架中的研究进展
姚梦竹1, 盛晓霞2, 林军3, 高建青1
1. 浙江大学药学院药物制剂研究所, 浙江 杭州 310058;
2. 杭州领业医药科技有限公司, 浙江 杭州 310058;
3. 浙江大学医学院附属第一医院口腔科, 浙江 杭州 310006
Research progress on application of carbon nanotubes in bone tissue engineering scaffold
YAO Mengzhu1, SHENG Xiaoxia2, LIN Jun3, GAO Jianqing1
1. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China;
2. Hangzhou Solipharma Co. Ltd, Hangzhou 310058,China;
3. Department of Stomatology,the First Affiliated Hospital,Zhejiang University School of Medicine, Hangzhou 310009, China
全文: PDF(1009 KB)  
摘要: 

碳纳米管具有良好的机械力学性能、导电性,作为最为广泛使用的纳米材料之一,在医药领域也展现了广阔的应用前景。采用粒子致孔法、热致相分离(冷冻干燥法)、微球聚集法、静电纺丝和三维打印等方法,可实现碳纳米管与无机材料、天然可降解高分子材料、人工合成可降解高分子材料等的复合,构建复合骨组织工程支架。不同材料的组合克服了单一材料的缺点,可以制备出与骨组织天然构造更加吻合,同时具有良好的生物相容性、骨传导性以及骨诱导性的骨组织工程支架。随着碳纳米管表面化学、毒理学研究的深入,生物相容性良好、具有一定降解性或降解产物安全的"人体友好型"碳纳米管的诞生值得期待。
关键词 ： 纳米管,碳,  骨和骨组织,  支架,  组织工程,  综述    
Abstract：

Carbon nanotubes possess excellent mechanical and electrical properties and demonstrate broad application prospects in medical fields. Carbon nanotubes are composed of inorganic materials, natural biodegradable polymer or synthetic biodegradable polymer. The composite bone tissue engineering scaffolds are constructed by particle-hole method, lyophilization, microsphere aggregation method, electrostatic spinning or three-dimensional printing. Composite scaffolds overcome the shortcomings of single material and have good biocompatibility, osteoconduction and osteoinduction. With the study of surface chemistry, toxicology, and biocompatibility, a degradable "human-friendly" carbon nanotubes composite bone tissue scaffold will be available; and under the drive of new fabrication techniques, the clinical application of carbon nanotubes composite bone tissue engineering scaffolds will be better developed.
Key words： Nanotubes, carbon    Bone and bone    Scaffolds    Tissue engineering    Review
收稿日期: 2016-01-07     
CLC:  R68  
基金资助:

国家自然科学基金(81271955)
通讯作者: 高建青(1969-),男,博士,教授,博士生导师,从事新型药物靶向系统的研究;E-mail:gaojianqing@zju.edu.cn     E-mail: gaojianqing@zju.edu.cn
作者简介: 姚梦竹(1989-),女,硕士研究生,从事组织工程支架研究;E-mail:yao_mengzhu@163.com
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姚梦竹 等. 碳纳米管在骨组织工程支架中的研究进展[J]. 浙江大学学报（医学版）, 2016, 45(2): 161-169.
YAO Mengzhu, SHENG Xiaoxia, LIN Jun, GAO Jianqing. Research progress on application of carbon nanotubes in bone tissue engineering scaffold. Journal of ZheJiang University(Medical Science), 2016, 45(2): 161-169.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.03.09      或      http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I2/161

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