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浙江大学学报（医学版）
浙江大学学报（医学版）  2016, Vol. 45 Issue (2): 152-160    DOI: 10.3785/j.issn.1008-9292.2016.03.08
运动系统再生医学专题     
蚕丝相关组织工程支架在肌腱和韧带再生修复中的应用
胡叶君1, 乐辉辉2, 金张楚1,2, 陈晓1, 茵梓1, 沈炜亮1,2, 欧阳宏伟1
1. 浙江大学医学院干细胞与再生医学系 浙江大学李达三·叶耀珍干细胞与再生医学研究中心 浙江省组织工程与再生医学技术重点实验室, 浙江 杭州 310058;
2. 浙江大学医学院附属第二医院骨科 浙江大学骨科研究所, 浙江 杭州 310009
Application of silk-based tissue engineering scaffold for tendon / ligament regeneration
HU Yejun1, LE Huihui2, JIN Zhangchu1,2, CHEN Xiao1, YIN Zi1, SHEN Weiliang1,2, OUYANG Hongwei1
1. Center of Stem Cell and Tissue Engineering, Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Key Laboratory of Stem Cell of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China;
2. Department of Orthopedic Surgery, Orthopedics Research Iustitute of Zhejiang University, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
全文: PDF(995 KB)  
摘要: 

肌腱和韧带损伤是临床常见运动系统损伤之一。传统治疗手段因供体来源有限、机体免疫排斥等局限,尚无法达到令人满意的临床疗效,尤其是对那些竞技运动员。目前的组织工程学手段能够突破传统治疗的局限,促进肌腱和韧带损伤的修复再生。蚕丝是一种天然的生物材料,具有生物相容性较好、力学强度跨度大和物理结构可调节等特性,可以作为肌腱和韧带的组织工程支架。以蚕丝支架为核心提供力学支持,复合胶原等其他生物成分能增加支架的三维空间,促进更多细胞黏附,并提升材料的生物相容性。体内研究逐步验证了蚕丝支架在发病率较高的肌腱和韧带(前交叉韧带、内侧副韧带、跟腱、肩袖韧带)修复中的临床应用潜能。生物力学良好,宿主自然整合的组织工程肌腱和韧带需要深入基础微观领域研究和延伸临床操作领域研究,促进产品走出实验室,开辟临床应用新航路,为肌腱和韧带损伤患者带来新的希望。本文就蚕丝相关组织工程支架的历史演变及其用于肌腱和韧带损伤修复的效果进行综述和展望。
关键词 ： 蚕属,  腱损伤,  韧带,  支架,  修复外科手术,  组织工程,  再生,  综述    
Abstract：

Tendon/ligament injury is one of the most common impairments in sports medicine. The traditional treatments of damaged tissue repair are unsatisfactory, especially for athletes, due to lack of donor and immune rejection. The strategy of tissue engineering may break through these limitations, and bring new hopes to tendon/ligament repair, even regeneration. Silk is a kind of natural biomaterials, which has good biocompatibility, wide range of mechanical properties and tunable physical structures; so it could be applied as tendon/ligament tissue engineering scaffolds. The silk-based scaffold has robust mechanical properties; combined with other biological ingredients, it could increase the surface area, promote more cell adhesion and improve the biocompatibility. The potential clinical application of silk-based scaffold has been confirmed by in vivo studies on tendon/ligament repairing, such as anterior cruciate ligament, medial collateral ligament, achilles tendon and rotator cuff. To develop novel biomechanically stable and host integrated tissue engineered tendon/ligament needs more further micro and macro studies, combined with product development and clinical application, which will give new hope to patients with tendon/ligament injury.
Key words： Bombyx    Tendon injuries    Ligaments    Scaffolds    Reconstructive surgical procedures    Tissue engineering    Regeneration    Review
收稿日期: 2015-11-26     
CLC:  R686  
基金资助:

国家自然科学基金(81572157,81201396,81572115);国家自然科学青年基金(81271970);浙江省自然科学基金(LY14H060003)
通讯作者: 欧阳宏伟(1971-),男,博士,教授,博士生导师,从事干细胞与组织工程、运动医学研究;E-mail:hwoy@zju.edu.cn;沈炜亮(1982-),男,博士,主治医师,硕士生导师,从事骨科疾病研究;E-mail:shenweiliang365@163.com     E-mail: hwoy@zju.edu.cn;shenweiliang365@163.com
作者简介: 胡叶君(1988-),男,博士研究生,从事运动医学研究;E-mail:huyejun@zju.edu.cn
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引用本文:

胡叶君 等. 蚕丝相关组织工程支架在肌腱和韧带再生修复中的应用[J]. 浙江大学学报（医学版）, 2016, 45(2): 152-160.
HU Yejun, LE Huihui, JIN Zhangchu, CHEN Xiao, YIN Zi, SHEN Weiliang, OUYANG Hongwei. Application of silk-based tissue engineering scaffold for tendon / ligament regeneration. Journal of ZheJiang University(Medical Science), 2016, 45(2): 152-160.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.03.08      或      http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I2/152

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