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浙江大学学报（医学版）
浙江大学学报（医学版）  2016, Vol. 45 Issue (2): 132-140    DOI: 10.3785/j.issn.1008-9292.2016.03.05
运动系统再生医学专题     
椎间盘纤维环组织工程研究进展
周平辉1, 过倩萍2, 凌峰1, 钱忠来1, 李斌1,2
1. 苏州大学附属第一医院骨科, 江苏 苏州 215006;
2. 苏州大学骨科研究所, 江苏 苏州 215007
Progress and challenges in tissue engineering of intervertebral disc annulus fibrosus
ZHOU Pinghui1, GUO Qianping2, LING Feng1, QIAN Zhonglai1, LI Bin1,2
1. Department of Orthopedics, the First Affiliated Hospital of Soochow University, Suzhou 215006, China;
2. Orthopedic Institute, Soochow University, Suzhou 215007, China
全文: PDF(997 KB)  
摘要: 

椎间盘退行性疾病是引起下腰痛的主要病因,严重影响患者的生活质量。纤维环损伤能导致椎间盘严重退变。然而,由于纤维环组织本身在细胞、生物化学和生物力学方面的异质性,纤维环的修复和再生治疗仍面临挑战。近年来,随着组织工程学的发展,利用组织工程化的纤维环为治疗退变椎间盘提供了新的途径。本文从组织工程的主要要素,即细胞、支架、生长因子和力学刺激等方面简要介绍纤维环组织工程业已取得的成果和面临的挑战。进一步研究需结合多学科手段,选取高效的细胞来源、制备多重仿生的支架、利用合适的生长因子和力学刺激等,充分模拟实际纤维环组织及其微环境,从而有效地促进纤维环组织再生,最终实现纤维环组织工程应用于椎间盘退行性疾病的临床治疗。
关键词 ： 椎间盘移位/治疗,  细胞移植,  支架,  腰椎/病理学,  转化生长因子β1/代谢,  椎间盘/病理学,  纤维化,  组织工程,  综述    
Abstract：

Degenerative disc disease (DDD) is a leading cause of low back pain, which severely affects the quality of life and incurs significant medical cost. Annulus fibrosus(AF) injuries can lead to substantial deterioration of intervertebral disc degeneration. However, the AF repair/regeneration remains a challenge due to the intrinsic cellular, biochemical and biomechanical heterogeneity of AF tissue. Tissue engineering would be a promising approach for AF regeneration. This article aims to provide a brief overview of the fundamental aspects of AF, the current achievements and future challenges of AF tissue engineering. A multidisciplinary approach is proposed for future studies to fully mimic the native AF tissue and its microenvironment, including choosing adequate cell source, preparing scaffolds with hierarchical microstructures, supplementing appropriate growth factors, and enforcing suitable mechanical stimulation. Hopefully, the engineered AF tissues would be effectively used to facilitate the treatment of DDD in the future.
Key words： Intervertebral disk displacement/therapy    Cell transplantation    Scaffolds    Lumbar vertebrae/pathology    Transforming growth factor beta1/metabolism    Intervertebral disk/pathology    Fibrosis    Tissue engineering    Review
收稿日期: 2015-10-12     
CLC:  R68  
基金资助:

国家自然科学基金(81171479,31530024)
通讯作者: 李斌(1974-),男,博士,特聘教授,博士生导师,从事骨科生物材料与再生医学研究;E-mail:binli@suda.edu.cn     E-mail: binli@suda.edu.cn
作者简介: 周平辉(1983-),男,博士研究生,主治医师,从事脊柱疾病的临床与基础研究;E-mail:37601745@qq.com
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引用本文:

周平辉 等. 椎间盘纤维环组织工程研究进展[J]. 浙江大学学报（医学版）, 2016, 45(2): 132-140.
ZHOU Pinghui, GUO Qianping, LING Feng, QIAN Zhonglai, LI Bin. Progress and challenges in tissue engineering of intervertebral disc annulus fibrosus. Journal of ZheJiang University(Medical Science), 2016, 45(2): 132-140.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2016.03.05      或      http://www.zjujournals.com/xueshu/med/CN/Y2016/V45/I2/132

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