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浙江大学学报（医学版）
浙江大学学报（医学版）  2015, Vol. 44 Issue (6): 672-677    DOI: 10.3785/j.issn.1008-9292.2015.11.12
综述     
脉冲电场肿瘤消融激发免疫反应的研究进展
崔光莹, 刁宏燕
浙江大学医学院附属第一医院传染病诊治国家重点实验室, 浙江 杭州 310003;
感染性疾病诊治协同创新中心, 浙江 杭州 310003
Research advances of anti-tumor immune response induced by pulse electric field ablation
CUI Guang-ying, DIAO Hong-yan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China
全文: PDF(706 KB)  
摘要: 

脉冲电场作为一种新型的肿瘤治疗手段,显示出了良好的临床应用前景。本文综述了微秒脉冲电场和纳秒脉冲电场肿瘤消融的特点,主要阐述了脉冲电场肿瘤消融激发抗肿瘤免疫反应的研究进展,指出了脉冲电场不仅能够导致肿瘤局部彻底消融,还能激发机体保护性免疫反应,进而抑制肿瘤的复发和转移。这些独特优势对于肿瘤治疗有着广阔的临床应用前景。然而,脉冲电场消融所激发的保护性免疫反应的机制及肿瘤疫苗的研发是未来亟待解决的科学问题。
关键词 ： 肿瘤/治疗,  电穿孔,  电化学疗法,  电磁场,  综述    
Abstract：

As a novel tumor therapy, pulse electric field has shown a clinical perspective. This paper reviews the characteristics of tumor ablation by microsecond pulse and nanosecond pulse electric field, and the research advances of anti-tumor immune response induced by pulse electric field ablation. Recent researches indicate that the pulse electric field not only leads to a complete ablation of local tumor, but also stimulates a protective immune response, thereby inhibiting tumor recurrence and metastasis. These unique advantages will show an extensive clinical application in the future. However, the mechanism of anti-tumor immune response and the development of related tumor vaccine need further studies.
Key words： Neoplasms/therapy    Electroporation    Electrochemotherapy    Electromagnetic fields    Review
收稿日期: 2015-06-30 出版日期: 2015-11-12
CLC:  R730.5  
基金资助:

国家自然科学基金(81271810);浙江省自然科学基金(LY16H190002)
通讯作者: 刁宏燕(1970-),女,博士,教授,主要从事感染免疫和细胞免疫学研究;E-mail:diaohy@zju.edu.cn;http://orcid.org/0000-0002-7197-4051     E-mail: diaohy@zju.edu.cn
作者简介: 崔光莹(1986-),女,博士研究生,主要研究方向为感染免疫和细胞免疫学研究;E-mail:cuiguangying1986@163.com;http://orcid.org/0000-0003-3656-8100
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引用本文:

崔光莹等. 脉冲电场肿瘤消融激发免疫反应的研究进展[J]. 浙江大学学报（医学版）, 2015, 44(6): 672-677.
CUI Guang-ying, DIAO Hong-yan. Research advances of anti-tumor immune response induced by pulse electric field ablation. Journal of ZheJiang University(Medical Science), 2015, 44(6): 672-677.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2015.11.12      或      http://www.zjujournals.com/xueshu/med/CN/Y2015/V44/I6/672

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