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浙江大学学报（医学版）
浙江大学学报（医学版）  2015, Vol. 44 Issue (6): 665-671    DOI: 10.3785/j.issn.1008-9292.2015.11.11
原著     
交联壳聚糖/聚丙烯酸/聚氧化乙烯包埋三七颗粒纳米纤维的制备及其性能研究
邢桂英1, 邵林军2
1. 绍兴文理学院医学院, 浙江 绍兴 312000;
2. 绍兴文理学院化学化工学院, 浙江 绍兴 312000
Preparation and performance characterization of pseudo-ginseng entrapped in crosslinked chitosan/polyacrylic acid/poly(ethylene oxide) nanofibrous membrane
XING Gui-ying1, SHAO Lin-jun2
1. School of Medical Sciences, Shaoxing University, Shaoxing 312000, China;
2. College of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China
全文: PDF(1724 KB)  
摘要: 

目的:制备交联壳聚糖/聚丙烯酸/聚氧化乙烯负载三七颗粒纳米纤维膜中药制剂,并对其体外释药特性进行研究。方法:以三七颗粒为模型中药,壳聚糖、聚丙烯酸和聚氧化乙烯为载体,利用静电纺丝和热交联技术,制备纤维膜型中药制剂;采用扫描电镜观察纤维膜的形貌,红外光谱研究纤维膜的化学结构,热失重研究样品的热稳定性,用紫外可见光谱仪表征纤维膜活性成分的释放性能。结果:交联壳聚糖/聚丙烯酸/聚氧化乙烯负载三七颗粒纳米纤维膜纤维直径为(181±71) nm。热交联使纤维膜的拉伸强度提高了35.3%,热分解温度从180℃提高到197℃,增加了纤维膜的结构稳定性。体外释药结果显示相比于普通的涂覆膜,纤维结构提高了药物活性组分的释放速率和释放总量。结论:交联壳聚糖/聚丙烯酸/聚氧化乙烯负载三七颗粒纳米纤维膜制备工艺简单,载药均匀,具有良好的释药性能,是一种有效的中药新剂型。
关键词 ： 三七/生产和制备,  壳聚糖,  纳米技术,  药物释放系统,  工艺学,制药,  纤维化    
Abstract：

Objective: To prepare the cross-linked chitosan/poly(acrylic acid)/poly (ethylene oxide) nanofibrous membrance loaded with pseudo-ginseng and to determine its characteristics. Methods: Pseudo-ginseng entrapped in chitosan, poly (acrylic acid), poly (ethylene oxide) nanofibrous membrane loaded with pseudo-ginseng was prepared by electrospinning and thermal treatment method. The surface morphology of fiber membrane was observed by scanning electron microscopy and the chemical structures were characterized by infrared spectroscopy; the thermal decomposition temperature was analyzed by the thermogravimetric analysis. UV-Vis spectra were used to evaluate the in vitro release properties. Results: The average diameter of the prepared nanofibrous particles was (181±71) nm. The tensile strength of fiber membrane increased by 35.3% and the decomposition temperature increased from 197℃ to 208℃ after crosslinking. Compared with casting film, the structure of fiber membrane increased the release rate and the overall amount of active components from pseudo-ginseng. Conclusion: The preparation of chitosan fiber loaded with pseudo-ginseng is simple and the dispersion of pseudo-ginseng is homogeneous. This fibrous pseudo-ginseng exhibited good release performance, providing a new Chinese medicine formulation.
Key words： Pseudo-ginseng/production &    preparation    Chitosan    Nanotechnology    Drug delivery systems    Technology, pharmaceutical    Fibrosis
收稿日期: 2015-08-14 出版日期: 2015-12-12
CLC:  TB383  
基金资助:

浙江省自然科学基金(LQ14E030003);绍兴文理学院校级资助项目(2011LG1027)
作者简介: 邢桂英(1981-),女,硕士,实验师,主要从事纳米中药研究;E-mail:312087578@qq.com;htty://orcid.org/0000-0002-0139-2929
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引用本文:

邢桂英等. 交联壳聚糖/聚丙烯酸/聚氧化乙烯包埋三七颗粒纳米纤维的制备及其性能研究[J]. 浙江大学学报（医学版）, 2015, 44(6): 665-671.
XING Gui-ying, SHAO Lin-jun. Preparation and performance characterization of pseudo-ginseng entrapped in crosslinked chitosan/polyacrylic acid/poly(ethylene oxide) nanofibrous membrane. Journal of ZheJiang University(Medical Science), 2015, 44(6): 665-671.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2015.11.11      或      http://www.zjujournals.com/xueshu/med/CN/Y2015/V44/I6/665

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