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浙江大学学报（医学版）
浙江大学学报（医学版）  2015, Vol. 44 Issue (5): 584-588    DOI: 10.3785/j.issn.1008-9292.2015.09.18
综述     
肾脏树突状细胞研究进展
陈瑞玲1,2, 潘建平1
1. 浙江大学城市学院医学院, 浙江杭州 310015;
2. 浙江大学医学院病原生物学系, 浙江杭州 310058
Research progress in kidney dendritic cells
CHEN Rui-ling1,2, PAN Jian-ping1
1. Zhejiang University City College School of Medicine, Hangzhou 310015, China;
2. Department of Pathogen Biology, Zhejiang University School of Medicine, Hangzhou 310058, China
全文: PDF(604 KB)  
摘要: 

肾脏树突状细胞(DC)在肾脏疾病的发生发展中扮演重要角色。肾脏DC在某些肾脏疾病中可表现为抗炎作用,而在另一些肾脏疾病中表现为促炎作用,甚至在某一疾病过程中其作用可发生变化,提示肾脏微环境对肾脏DC的分化和功能具有重要的影响。本文就肾脏DC的来源、种类和分布,肾脏DC在狼疮性肾炎和肾盂肾炎等肾脏疾病发生发展中的作用和机制,以及近端小管上皮细胞对DC功能调节作用等方面的研究进展作一综述。
关键词 ： 狼疮肾炎/免疫学,  肾盂肾炎/免疫学,  肾疾病/免疫学,  肾,  树突细胞/免疫学,  综述    
Abstract：

Kidney dendritic cells(DC) play important roles in the pathogenesis of kidney diseases. Kidney DC presents anti-inflammatory effects in certain kidney diseases, sometimes presents pro-inflammation in other diseases, and sometimes their effects are changing in different stages of the disease, suggesting that the differentiation and function of kidney DC may be influenced by microenvironment. This article reviews the origin and distribution of kidney DC subsets and their roles in the pathogenesis of kidney diseases such as lupus nephritis and pyelonephritis, and the functional regulation of kidney DC by proximal tubule epithelial cells.
Key words： Lupus nephritis/immunology    Pyelonephritis/immunolog    Kidney diseases/immunology    Kidney    Dendritic cells/immunology    Review
收稿日期: 2014-12-16
CLC:  R392  
基金资助:

浙江省医药卫生科技计划(2013KYA149);杭州市科技发展计划(20120633B30)
通讯作者: 潘建平(1962-),男,博士,教授,博士生导师,从事免疫学研究;E-mail:jppan@zucc.edu.cn;http://orcid.org/0000-0001-9636-1561     E-mail: jppan@zucc.edu.cn
作者简介: 陈瑞玲(1989-),女,硕士研究生,主要从事感染免疫学研究;E-mail:crl974888563@126.com;http://orcid.org/0000-0002-6372-1927
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引用本文:

陈瑞玲, 潘建平. 肾脏树突状细胞研究进展[J]. 浙江大学学报（医学版）, 2015, 44(5): 584-588.
CHEN Rui-ling, PAN Jian-ping. Research progress in kidney dendritic cells. Journal of ZheJiang University(Medical Science), 2015, 44(5): 584-588.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2015.09.18      或      http://www.zjujournals.com/xueshu/med/CN/Y2015/V44/I5/584

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