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浙江大学学报（医学版）
浙江大学学报（医学版）  2015, Vol. 44 Issue (4): 417-422    DOI: 10.3785/j.issn.1008-9292.2015.07.11
原著     
丙型肝炎病毒基因型在中国大陆汉族慢性丙型肝炎患者中的分布特征
毛小荣1, 张立婷1, 蒋妮1, 肖萍1, 彭雪彬1, 张有成2
1. 兰州大学第一医院感染科, 甘肃 兰州 730000;
2. 兰州大学第二医院普外科, 甘肃 兰州 730000
Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C
MAO Xiao-rong1, ZHANG Li-ting1, JIANG Ni1, XIAO Ping1, PENG Xue-bin1, ZHANG You-cheng2
1. Department of Infectious Diseases, the First Hospital of Lanzhou University, Lanzhou 730000, China;
2. Department of General Surgery, the Second Hospital of Lanzhou University, Lanzhou 730000, China
全文: PDF(686 KB)  
摘要: 

目的:调查中国大陆汉族慢性丙型肝炎(CHC)患者的HCV基因型与地区分布、性别、HCV-RNA复制水平之间的关系.方法:选取来自中国大陆不同地区28家医院的1 014例汉族CHC患者,对其性别、分布区域、HCV基因型、HCV-RNA复制水平等指标进行调查,用SPSS 20.0软件进行数据处理,采用χ2检验分析各指标的相互关系.结果:①中国大陆HCV 1型患者人数最多(56.80%);除西南、华南、华中地区外,其余地区HCV基因型分布频度均为HCV 1型>HCV 2型>HCV 3型>HCV 6型.②HCV 1型在华南地区男性患者多见(P <0.05);HCV 2型在华北地区女性多见(P <0.05);HCV 3型在华北、西北地区男性多见(P <0.05);HCV 6型在西北地区男性多见(P <0.05),其余各地区不同性别间HCV基因型分布差异无统计学意义.③在HCV 1、HCV 2、HCV 3、HCV 6型中,均多见HCV-RNA高水平复制,低水平复制患者数最少.结论:中国大陆汉族CHC患者HCV基因型在各地区分布不同,并与性别、HCV-RNA复制水平有关.
关键词 ： 肝炎,  丙型/病毒学,  肝炎病毒/遗传学,  基因型,  肝炎,  慢性/病毒学,  序列分析,  基因,  病毒/遗传学,  中国,  性别分布    
Abstract：

Objective: To investigate the distribution of HCV genotypes in Chinese Han population with chronic hepatitis C (CHC). Methods: This randomized multicenter study included 1 014 CHC patients from 28 hospitals in different regions of China. SPSS 20.0 was applied to analyze the relationship among region, HCV genotype, gender and the replication level of HCV-RNA. Results: HCV 1 genotype (56.80%) was the most common genotype. The majority of CHC patients were of genotype 1, 2, 3, 6 in the order of frequency, except those in southwestern, southern and central China. HCV 1, 2, 3, 6 genotypes were most common among male patients in southern China; among female patients in northern China; among male patients in northern and northwestern China and among male patients in northwestern China, respectively (all P <0.05). There was no statistical significance between different genders in other regions. The high viral load was more common than the low viral load among HCV 1, 2, 3, 6 genotype-infected patients. Conclusion: There are different distributions of HCV genotypes among the different regions. In addition, HCV genotypes are correlated with gender and HCV-RNA load.
Key words： Hepatitis C/virology    Hepatitis viruses/genetics    Genotype    Hepatitis, chronic/virology    Sequence analysis    Genes, viral/genetics    China    Sex distribution
收稿日期: 2015-01-06
CLC:  R51  
基金资助:

甘肃省自然科学基金(0803RJZA057);中央高校基本科研项目专项资金(lzujbky2009150)
通讯作者: 张有成(1962-),男,博士,主任医师,主要从事肝病的基础与临床研究;E-mail:youchengzhang12@hotmail.com;http://orcid.org/0000-0002-4404-8079     E-mail: youchengzhang12@hotmail.com
作者简介: 毛小荣(1971-),女,博士,主任医师,主要从事肝病的基础与临床研究;E-mail:mxr2013@126.com;http://orcid.org/0000-0003-1952-1554
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引用本文:

毛小荣, 张立婷, 蒋妮, 肖萍, 彭雪彬, 张有成. 丙型肝炎病毒基因型在中国大陆汉族慢性丙型肝炎患者中的分布特征[J]. 浙江大学学报（医学版）, 2015, 44(4): 417-422.
MAO Xiao-rong, ZHANG Li-ting, JIANG Ni, XIAO Ping, PENG Xue-bin, ZHANG You-cheng. Distribution of HCV genotypes in Chinese Han population with chronic hepatitis C. Journal of ZheJiang University(Medical Science), 2015, 44(4): 417-422.

链接本文:

http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2015.07.11      或      http://www.zjujournals.com/xueshu/med/CN/Y2015/V44/I4/417

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