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浙江大学学报(医学版)  2015, Vol. 44 Issue (3): 349-353    DOI: 10.3785/j.issn.1008-9292.2015.05.18
综述     
生命早期营养不良与成年期心血管功能的关系
劳林江1, 章丽燕2, 杜立中1
1. 浙江大学医学院附属儿童医院新生儿科, 浙江 杭州 310003;
2. 福州儿童医院新生儿科, 福建 福州 350000
Malnutrition in early life and cardiovascular disease in adulthood
LAO Lin-jiang1, ZHANG Li-yan2, DU Li-zhong1
1. Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;
2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China
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摘要:

流行病学调查和实验研究发现成年期心血管疾病除了与遗传和生活方式相关外,还受生命早期营养环境的影响。宫内和出生后早期营养不良及相伴随的追赶生长模式均影响成年期血压、内皮功能等心血管指标。目前已建立多种出生前和(或)出生后营养干预的动物模型研究不同干预方式对成年期心血管功能的影响。本综述结合“健康与疾病的发育起源”假说相关概念阐述成年期心血管疾病的早期营养起源,并对可能的预防措施提出设想。

关键词: 心血管疾病/病因学心血管疾病/流行病学胎儿发育营养不良模型动物综述    
Abstract:

Epidemiological and experimental studies have demonstrated that the risk of cardiovascular disease(CVD) in adulthood is influenced by the environment in early life. Intrauterine and early postnatal malnutrition and the following catch-up growth have a long-term effect on blood pressure and endothelial function in adulthood. Well-established prenatal or/and postnatal animal models are used to study the impact of different nutritional intervention on CVD in adulthood. This article reviews the early original cause of chronic CVD in adulthood with the hypothesis of DOHaD(the developmental origins of health and disease), and proposes possible preventions in early life on the basis of this theory.

Key words: Cardiovascular diseases/etiology    Cardiovascular diseases/epidemiology    Fetal development    Malnutrition    Models, animal    Review
收稿日期: 2015-01-22 出版日期: 2015-05-25
:  R715  
基金资助:

国家自然科学基金(81471480,81270722)

通讯作者: 杜立中(1958-),男,博士,主任医师,教授,主要从事新生儿领域相关研究;E-mail:dulizhong@zju.edu.cn;http://orcid.org/0000-0002-3181-810X     E-mail: dulizhong@zju.edu.cn
作者简介: 劳林江(1988-),男,硕士研究生,主要研究方向为早期营养和成年期肺疾病;E-mail:laolinjiang@gmail.com;http://orcid.org/0000-0001-6862-9903
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引用本文:

劳林江, 章丽燕, 杜立中. 生命早期营养不良与成年期心血管功能的关系[J]. 浙江大学学报(医学版), 2015, 44(3): 349-353.

LAO Lin-jiang, ZHANG Li-yan, DU Li-zhong. Malnutrition in early life and cardiovascular disease in adulthood. Journal of ZheJiang University(Medical Science), 2015, 44(3): 349-353.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2015.05.18        http://www.zjujournals.com/med/CN/Y2015/V44/I3/349

[1] YANG Z J, LIU J, GE J P, et al. Prevalence of cardiovascular disease risk factor in the Chinese population: the 2007-2008 China National Diabetes and Metabolic Disorders Study[J]. Eur Heart J, 2012,33(2):213-210.
[2] SINGHAL A, COLE T J, LUCAS A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials[J]. Lancet, 2001,357(9254):413-419.
[3] GLUCKMAN P D, HANSON M A.The developmental origins of health and disease[M]. New York: Cambridge University Press,2006:1-5.
[4] CALKINS K, DEVASKAR S U.Fetal origins of adult disease[J]. Curr Probl Pediatr Adolesc Health Care, 2011,41(6):158-176.
[5] HALES C N, BARKER D J.Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis[J]. Diabetologia, 1992,35(7):595-601.
[6] GLUCKMAN P D, HANSON M A.Living with the past: evolution, development, and patterns of disease[J]. Science,2004,305(5691):1733-1736.
[7] 魏克伦,杨于嘉,姚裕家,等.中国城市早产儿流行病学初步调查报告[J].中国当代儿科杂志,2005,7(1):25-28. WEI Ke-Lun, YANG Yu-Jia, YAO Yu-Jia, et al. An initial epidemiologic investigation of preterm infants in cities of China[J]. Chinese Journal of Contemporary Pediatrics,2005,7(1):25-28.(in Chinese)
[8] BARKER D J, OSMOND C,GOLDING J, et al. Growth in utero,blood pressure in childhood and adult life,and mortality from cardiovascular disease[J]. BMJ,1989, 298(6673):564-567.
[9] RICH-EDWARDS J W, STAMPFER M J,MANSON J E, et al. Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976[J]. BMJ,1997, 315(7105):396-400.
[10] HUXLEY R R, SHIELL A W, LAW C M. The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature[J]. J Hypertens,2000,18(7):815-831.
[11] LEESON C P, KATTENHORN M, MORLEY R, et al. Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life[J]. Circulation,2001,103(9):1264-1268.
[12] BARKER D J,GLUCKMAN P D,GODFREY K M,et al.Fetal nutrition and cardiovascular disease in adult life[J].Lancet,1993,341(8850):938-941.
[13] NORMAN M, MARTIN H. Preterm birth attenuates association between low birth weight and endothelial dysfunction[J]. Circulation,2003,108(8):996-1001.
[14] DE JONG F, MONUTEAUX M C, VAN ELBURG R M,et al.Systematic review and meta-analysis of preterm birth and later systolic blood pressure[J]. Hypertension, 2012,59(2):226-234.
[15] BROOKE O G, ANDERSON H R, BLAND J M, et al. Effects on birth weight of smoking, alcohol, caffeine, socioeconomic factors, and psychosocial stress[J]. BMJ,1989, 298(6676):795-801.
[16] ROGERS L K, VELTEN M. Maternal inflammation, growth retardation, and preterm birth: insights into adult cardiovascular disease[J]. Life Sci,2011, 89(13-14):417-421.
[17] TURNER S, PRABHU N,DANIELAN P, et al. First-and second-trimester fetal size and asthma outcomes at age 10 years[J]. Am J Resp Crit Care Med,2011,184(4):407-413.
[18] ELMES M J, GARDNER D S, LANGLEY-EVANS S C. Fetal exposure to a maternal low-protein diet is associated with altered left ventricular pressure response to ischaemia-reperfusion injury[J]. Br J Nutr,2007,98(1):93-100.
[19] TORRENS C, HANSON M A, GLUCKMAN P D, et al. Maternal undernutrition leads to endothelial dysfunction in adult male rat offspring independent of postnatal diet[J]. Br J Nutr,2009,101(1):27-33.
[20] WOODALL S M, JOHNSTON B M, BREIER B H,et al. Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring[J]. Pediatr Res,1996,40(3):438-443.
[21] ALEXANDER B T. Placental insufficiency leads to development of hypertension in growth-restricted offspring[J]. Hypertension,2003,41(3):457-462.
[22] BASERGA M, HALE M A, WANG Z M, et al. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension[J]. Am J Physiol Regul Integr Comp Physiol,2007,292(5):R1943-R1955.
[23] BRENNER B M,GARCIA D L,ANDERSON S.Glomeruli and blood pressure.Less of one, more the other?[J]. Am J Hypertens,1988,1(4 Pt 1):335-347.
[24] ORTIZ ESPEJO M,GIL CAMPOS M,MUNOZ VILLANUEVA M C,et al. Metabolic changes in prepuberty children with extrauterine growth restriction[J].An Pediatr(Barc), 2012,77(4):247-253.
[25] BARKER D J, OSMOND C, FORSON T J,et al.Trajectories of growth among children who have coronary events as adults[J]. N Engl J Med,2005,353(17):1802-1809.
[26] ERIKSSON J,FORSEN T,TUOMILEHTO J,et al.Fetal and childhood growth and hypertension in adult life[J]. Hypertension,2000,36(5):790-794.
[27] SINGHAL A, COLE T J, FEWTRELL M, et al. Promotion of faster weight gain in infants born small for gestational age: is there an adverse effect on later blood pressure?[J]. Circulation,2007,115(2):213-220.
[28] NICHOLAS K R, HARTMANN P E. Milk secretion in the rat: progressive changes in milk composition during lactation and weaning and the effect of diet[J]. Comp Biochem Physiol A Comp Physiol,1991,98(3-4):535-542.
[29] O'DOWD R, KENT J C, MOSELEY J M, et al. Effects of uteroplacental insufficiency and reducing litter size on maternal mammary function and postnatal offspring growth[J]. Am J Physiol Regul Integr Comp Physiol,2008,294(2):R539-548.
[30] DESAI M, GAYLE D, BABU J, et al. Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition[J]. Am J Physiol Regul Integr Comp Physiol,2005,288(1):R91-96.
[31] TOSH D N, FU Q, CALLAWAY C W, et al. Epigenetics of programmed obesity: alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth[J]. Am J Physiol Gastrointest Liver Physiol, 2010,299(5):G1023-1029.
[32] CLEAL J K, POORE K R, BOULLIN J P, et al.Mismatched pre-and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood[J]. Proc Natl Acad Sci U S A,2007,104(22):9529-9533.
[33] TARE M,PARKINGTON H C, BUBB K J, et al. Uteroplacental insufficiency and lactational environment separately influence arterial stiffness and vascular function in adult male rats[J]. Hypertension, 2012,60(2):378-386.
[34] TARRY-ADKINGS J L, MARTIN-GRONERT M S, FERNANDEZ-TWINN D S,et al. Poor maternal nutrition followed by accelerated postnatal growth leads to alterations in DNA damage and repair, oxidative and nitrosative stress,and oxidative defense capacity in rat heart[J]. FASEB J, 2013,27(1):379-390.
[35] BOL V,DESJARDINGS F,REUSENS B,et al. Does early mismatched nutrition predispose to hypertension and atherosclerosis, in male mice?[J]. PLoS One, 2010, 5(9). pii: e12656.
[36] ZHANG L, TANG L, WEI J, et al. Extrauterine growth restriction on pulmonary vascular endothelial dysfunction in adult male rats: the role of epigenetic mechanisms[J]. J Hypertens, 2014,32(11):2188-2198; discussion 2198.
[37] ROSEBOOM T,DE ROOIJ S,PAINTER R.The Dutch famine and its long-term consequences for adult health[J]. Early Hum Dev,2006,82(8):485-491.
[38] STANNER S A, YUDKIN J S.Fetal programming and the Leningrad Siege study[J]. Twin Res,2001,4(5):287-292.

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