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浙江大学学报（医学版）
浙江大学学报（医学版）  2015, Vol. 44 Issue (2): 131-137    DOI: 10.3785/j.issn.1008-9292.2015.03.003
专题报道     
人体全颈椎及椎动脉流固耦合模型的构建
王辉昊1,2, 沈知彼1,2, 邓真1,2, 王宽1,2, 詹红生1,2
1. 上海中医药大学附属曙光医院石氏伤科医学中心, 上海 201203;
2. 上海市中医药研究院骨伤科研究所, 上海 201203
Construction of a human cervical spine with bilateral vertebral artery fluid-solid coupling model
WANG Hui-hao1,2, SHEN Zhi-bi1,2, DENG Zhen1,2, WANG Kuan1,2, ZHAN Hong-sheng1,2
1. Shi's Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201203, China;
2. Institute of Traumatology & Orthopedics, Shanghai Academy of TCM, Shanghai 201203, China
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摘要：

目的:建立全颈椎生物力学数字仿真研究平台。方法:参考大量解剖学数据和人体颈椎标本的实验数据,应用逆向工程原理对序列螺旋CT 图片进行处理,分别构建颈椎椎体、椎动脉、韧带、椎间盘、关节面软骨和终板等结构模型,并从解剖形态和活动功能两方面验证该模型与人体生理状态的一致性。结果:构建了人体颈椎三维有限元模型,该模型椎体表面应力集中规律、双侧椎动脉血管壁所受应力特点以及血流速度—时间变化曲线等内容与文献报道的人体颈椎标本实验结果趋势一致,并能合理解释相对应的临床现象。结论:成功构建了人体全颈椎三维有限元流固耦合模型,该模型能为深入了解人体颈椎及其附属结构的生物力学机制提供新的研究思路。
关键词： 颈椎;  模型,解剖学;  血流速度;  椎动脉;  有限元分析    
Abstract:

Objective: To construct a human cervical spine with bilateral vertebral artery fluid-solid coupling model. Methods: Helical CT images under the principle of reverse engineering and meshed in finite element model(FEM) related software were used to establish a human cervical spine with bilateral vertebral artery fluid-solid coupling model. In the process of modeling of vertebral body, vertebral artery, ligament, intervertebral disc, cartilage and endplate large anatomic data and cadaver experiments results were referenced. From the morphology and function the simulation of model with real physiological status was tested. Results: The study showed that the stress concentration on the surface of vertebral body and the blood wall of the bilateral vertebral artery, and the result of the volume flow rate-time curve of bilateral vertebral artery of the model were consistent with the published literatures. This model was well consistent with the clinical phenomenon. Conclusion: The three-dimensional FEM of the human cervical spine established by the introduced method has been effectively verified. The modeling method would provide a new tool for research on the cervical spine biomechanics.
Key words: Cervical vertebrae    Models, anatomic    Blood flow velocity    Vertebral artery    Finite element analysis
收稿日期: 2014-11-17 出版日期: 2015-03-25
:  R318.01  
基金资助:

“中医骨伤科学”国家重点学科(100508); 国家自然科学基金(81473702、81001528); 上海领军人才项目(041);上海市科委重点项目(14401970402 、09dZ1973800); 上海高校“中医脊柱病损研究”创新团队建设项目(2009-26)
通讯作者: 詹红生(1964-),男,博士,主任医师,教授,博士生导师,主要从事骨和关节退行性疾病的防治研究;E-mail:zhanhongsheng2010@163.com     E-mail: zhanhongsheng2010@163.com
作者简介: 王辉昊(1986-),男,博士,实习研究员,主要从事中医药防治慢性筋骨病损的生物力学研究与临床疗效评价;E-mail:huihaowang@126.com
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引用本文:

王辉昊, 沈知彼, 邓真, 王宽, 詹红生. 人体全颈椎及椎动脉流固耦合模型的构建[J]. 浙江大学学报（医学版）, 2015, 44(2): 131-137.

WANG Hui-hao, SHEN Zhi-bi, DENG Zhen, WANG Kuan, ZHAN Hong-sheng. Construction of a human cervical spine with bilateral vertebral artery fluid-solid coupling model. Journal of ZheJiang University(Medical Science), 2015, 44(2): 131-137.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2015.03.003    或    http://www.zjujournals.com/med/CN/Y2015/V44/I2/131

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