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浙江大学学报（医学版）
浙江大学学报（医学版）  2014, Vol. 43 Issue (4): 406-412    DOI: 10.3785/j.issn.1008-9292.2014.07.003
专题报道     
转录因子FOXC1、基质金属蛋白酶7在不同乳腺癌分子亚型中的表达及与临床病理的相关性分析
曹培龙，王凯，王春宝，李晓峰，杨喆，王鸿雁
西安交通大学医学院第一附属医院病理科，陕西 西安710061
Expressions of FOXC1 and MMP-7 in molecular subtypes of breast cancer and their association with clinicopathological characteristics
CAO Pei-long， WANG Kai， WANG Chun-bao， LI Xiao-feng， YANG Zhe， WANG Hong-yan
Department of Pathology， First Affiliated Hospital of Xian Jiaotong University School of Medicine， Xian 710061， China
全文: PDF(1801 KB)  
摘要: 目的： 观察转录因子FOXC1、基质金属蛋白酶7（MMP-7）在乳腺癌各分子亚型中的表达情况，探讨FOXC1、MMP-7对乳腺癌分子亚型的诊断及预后价值。方法：105例乳腺癌患者根据免疫组织化学检测ER、PR、HER2、CK5/6、CK14、EGFR结果分为四型：腔型、HER2阳性型、基底细胞样型（BLs型）及正常乳腺样型（NBLs型）。观察各乳腺癌分子亚型的临床特征及与FOXC1、MMP-7的关系。结果：在105例乳腺癌患者中腔型、HER2阳性型、BLs型和NBLs型乳腺癌所占比例分别为52.4%（55/105）、16.2%（17/105）、17.1%（18/105）、14.3%（15/105）。腔型和（或）NBLs型乳腺癌患者5年生存率明显高于HER2阳性型和（或）BLs型患者（log-rank值为22.161，P<0.01）。FOXC1阳性表达共28例，阳性表达率为26.7%（28/105），FOXC1表达与肿瘤组织学分级、肿瘤大小、远处转移及患者5年生存率有关，而且FOXC1在BLs型乳腺癌中阳性表达率显著高于其他分子亚型乳腺癌（χ2=30.108，P<0.01）。MMP-7阳性表达共71例，阳性表达率为67.6%（71/105），MMP-7与患者同侧腋窝淋巴结转移、远处转移及患者5年生存率有关。MMP-7在BLs型乳腺癌中阳性表达率也高于其他分子亚型乳腺癌（χ2=11.328，P<0.05）。FOXC1与MMP-7的表达呈正相关（r=0.325， P<0.01）。结论：腔型和NBLs型乳腺癌患者预后较好，HER2阳性型和BLs型乳腺癌预后较差。FOXC1可能作为BLs型乳腺癌的特异性潜在分子标志物和潜在治疗靶点。MMP-7可能作为判断乳腺癌侵袭性、恶性程度及评估预后的有用指标。FOXC1与MMP-7在分子机制上可能存在一定的联系。
Abstract：Objective: To investigate the expressions of FOXC1 and matrix metalloproteinase 7 （MMP-7） in different molecular subtypes of breast cancer and their association with clinicopathological characteristics of the disease. Methods： Based on immunohistochemical results of ER， PR， HER2， CK5/6， CK14 and EGFR， 105 breast cancer patients were classified as 4 subtypes: luminal， HER2 positive， basal-like subtype （BLs） and normal breast-like subtype （NBLs）. The association of FOXC1 and MMP-7 expressions with clinicopathological parameters in different molecular subtypes was analyzed. Results： Out of 105 patients with breast cancer， the subtypes of luminal， HER2 positive， BLs and NBLs accounted for 52.4% （55/105）， 16.2% （17/105）， 17.1% （18/105） and 14.3% （15/105）， respectively. Patients with luminal and/or NBLs subtypes had significantly higher 5-year survival rate than those with HER2 positive and/or BLs did （log-rank=22.161， P<0.01）. The overall positive expression rate of FOXC1 was 26.7% （28/105） and the expression was higher in BLs patients than that in other subgroups （χ2=30.108， P<0.01）. The expression of FOXC1 was correlated with histological grade， tumor size， distant metastasis and 5-year survival rate of breast cancer. The overall positive expression rate of MMP-7 was 67.6% （71/105）and the expression of MMP-7 was also higher in BLs patients than that in other molecular subtypes （χ2=11.328， P<0.05）. The positive expression of MMP-7 was correlated with metastasis in ipsilateral axillary lymph nodes， distant metastasis and 5-year survival rate of the patients. FOXC1 was correlated with MMP-7 （r=0.325，P<0.01）.Conclusion： Patients with luminal and/or NBLs breast cancer have more favorable prognosis than those with HER2 positive and/or BLs subtypes. The expressions of FOXC1 and MMP-7 are closely correlated with the clinicopathological features of breast cancer patients．
Key words： Breast neoplasms/pathology丨Breast neoplasms/diagnosis丨FOXC1;Matrix metalloproteinase 7/metabolism丨Transcription factors/metabolism丨Gene expression    Prognosi丨Immunohistochemistry    Follow-up study
收稿日期: 2014-03-08
通讯作者: 王鸿雁（1967-），博士，主任医师，主要从事肿瘤病理研究；E-mail: whycc0320@126.com    
Corresponding author: WANG Hong-yan， E-mail: whycc0320@126.com   
作者简介: 曹培龙（1974-），硕士，主治医师，主要从事肿瘤病理研究；E-mail: cpl0208@163.com
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引用本文:

曹培龙，等. 转录因子FOXC1、基质金属蛋白酶7在不同乳腺癌分子亚型中的表达及与临床病理的相关性分析[J]. 浙江大学学报（医学版）, 2014, 43(4): 406-412.
CAO Pei-long，et al. Expressions of FOXC1 and MMP-7 in molecular subtypes of breast cancer and their association with clinicopathological characteristics . Journal of ZheJiang University(Medical Science), 2014, 43(4): 406-412.

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http://www.zjujournals.com/xueshu/med/CN/10.3785/j.issn.1008-9292.2014.07.003      或      http://www.zjujournals.com/xueshu/med/CN/Y2014/V43/I4/406

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