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浙江大学学报(医学版)  2013, Vol. 42 Issue (2): 237-241    DOI: 10.3785/j.issn.1008-9292.2013.02.017
综述     
乙型肝炎病毒对精子和辅助生殖技术结局的影响
李苗,朱依敏综述
浙江大学医学院附属妇产科医院,杭州 浙江 310006
Impact of hepatitis B virus on sperm parameters and outcome of assisted reproductive technology
LI Miao, ZHU Yi-Min
The Affiliated Obstetrics and Gynecology Hospital, Zhejiang University School of Medicine,Hangzhou 310006,China
 全文: PDF(629 KB)   HTML (
摘要:

乙型肝炎病毒(HBV)垂直传播近年来受到广泛关注,随着辅助生殖技术(ART)的迅猛发展,越来越多的HBV携带夫妇借助于ART获得了子代。然而,HBV的垂直传播现象仍然不可完全避免,尤其是父婴垂直传播。原因在于HBV感染精子的机制至今仍未阐明。了解HBV携带者精子的HBV感染状况及其与精子参数的关系,随访男性HBV患者接受ART治疗后的结局,揭示HBV感染精子的机制,将有助于在解决了生育问题的同时更好地为防控HBV的父婴垂直传播提供新的思路。

关键词: 肝炎病毒乙型生殖技术辅助疾病传播垂直精子妊娠结局综述    
Abstract:

With the development of assisted reproductive technology(ART),more and more hepatitis B virus(HBV)-infected couples have their own children successfully; however,vertical transmission of HBV in ART,especially father-to-child transmission,cannot be avoided.The mechanism of attachment and penetration of HBV into human sperm is still not known.Therefore,understanding the state and mechanism of HBV infection of sperm and the impact of HBV on sperm parameters,following up the ART outcome in man with HBV infection are helpful to solve the fertility problem and to control father-to-child vertical HBV infection.

Key words: Hepatitis B virus    Reproductive techniques,assisted    Disease transmission,vertical    Spermatozoma    Pregnancy outcome    Review
收稿日期: 2012-03-22 出版日期: 2013-03-25
:  R 713.7  
基金资助:

浙江省自然科学基金资助项目(491050+N21025);卫生部-卫生厅共建项目(491050-W11082).

通讯作者: 朱依敏(1964-),女,主任医师,主要从事生殖内分泌临床和研究     E-mail: zhuyim@zju.edu.cn
作者简介: 李苗(1987-),女,硕士生.
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引用本文:

李苗, 朱依敏. 乙型肝炎病毒对精子和辅助生殖技术结局的影响[J]. 浙江大学学报(医学版), 2013, 42(2): 237-241.

LI Miao, ZHU Yi-Min . Impact of hepatitis B virus on sperm parameters and outcome of assisted reproductive technology. Journal of ZheJiang University(Medical Science), 2013, 42(2): 237-241.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2013.02.017        http://www.zjujournals.com/med/CN/Y2013/V42/I2/237


[1]HADCHOUEL M,SCOTTO J,HURET J L,et al.Presence of HBV DNA in spermatozoa: a possible vertical transmission of HBV via the germ line
[J].J Med Virol,1985,16(1):61-66.

[2]HUANG J M,HUANG T H,QIU H Y,et al.Effects of hepatitis B virus infection on human sperm chromosomes
[J].World J Gastroenterol,2003,9(4):736-740.

[3]WANG S,PENG G,LI M,et al.Identification of hepatitis B virus vertical transmission from father to fetus by direct sequencing
[J].Southeast Asian J Trop Med Public Health,2003,34:106-113.


[4]TAJIRI H,TANAKA Y,KAGIMOTO S,et al.Molecular evidence of father-to-child transmission of hepatitis B virus
[J].J Med Virol,2007,79(7):922-926.


[5]ALI B A,HUANG T H,XIE Q D,et al..Detection and expression of hepat it is B Virus X gene in one and two cell embryos from golden hamster oocytes in vitro fertilized with human spermatozoa carrying HBV-DNA
[J].Mol Report Dev,2005,70(1): 30-36.


[6]HU X L,ZHOU X P,QIAN Y L,et al.The presence and expression of the hepatitis B virus in human oocytes and embryos.
[J].Hum Reprod,2011,26(7):1860-1867.

[7]NIE R,JIN L,ZHANG H,et al.Presence of hepatitis B virus in oocytes and embryos: a risk of hepatitis B virus transmission during in vitro fertilization
[J].Fertil Steril,2011,95(5):1667-1671.

[8]LORUSSO F,PALMISANO M,CHIRONNA M,et al.Depalo R.Impact of chronic viral diseases on semen parameters
[J].Andrologia,2010,42(2):121-126.

[9]ZHOU X P,HU XL,ZHU Y M,et al.Comparison of semen quality and outcome of assisted reproductive techniques in Chinese men with and without hepatitis B
[J].Asian J Androl,2011,13(3):465-469.

[10]MORETTI E,FEDERICO M G,GIANNERINI V,et al.Sperm ultrastructure and meiotic segregation in a group of patients with chronic hepatitis B and C
[J].Andrologia,2008,40(5):286-291.

[11]PIRWANY I R,PHILLIPS S,KELLY S,et al.Reproductive performance of couples discordant for hepatitis B and C following IVF treatment
[J].J Assist Reprod Genet,2004,21(5):157-161.

[12]OGER P,YAZBECK C,GERVAIS A,et al.Adverse effects of hepatitis B virus on sperm motility and fertilization ability during IVF
[J].Reprod Biomed Online,2011,23(2):207-212.

[13]VICARI E,ARCORIA D,DI MC,et al.Sperm output in patients with primary infertility and hepatitis B or C virus; negative influence of HBV infection during concomitant varicocele
[J].Minerva Med,2006,97(1):65-77.

[14]LEE V C,NG E H,YEUNG W S,et al.Impact of positive hepatitis B surface antigen on the outcome of IVF treatment
[J].Reproductive BioMedicine Online,2010,21(5) :712-717.

[15]ZHOU X L,SUN P N,HUANG T H,et al Effects of hepatitis B virus S protein on human sperm function
[J].Hum Reprod,2009,24(7):1575-1583.

[16]CHEN Jianwei,CUI Yun,ZHANG Xiaoxia(陈建伟,崔云,张晓霞).Investigate the impact of hepatitis B virus infection on sperm DNA integrity
[J].Chinese Journal of Experimental and Clinical Virology(中华实验和临床病毒学杂志),2011,25(5):345-347.(in Chinese).

[17]KANG X,XIE Q,ZHOU X,et al.Effects of hepatitis B virus S protein exposure on sperm membrane integrity and functions
[J].PLoS One,2012,7(3):e33471.

[18]JIANG H,HE R B,WANG C L,et al.The relationship of sperm DNA fragmentation index with the outcomes of in-vitro fertilisation-embryo transfer and intracytoplasmic sperm injection
[J].J Obstet Gynaecol,2011,31(7):636-639.

[19]ZHANG Ronglian,LUO Ying,XIE Jingxian,et al(张荣莲,罗颖,谢婧娴,等).A correlation analysis between the rate of vertical transmission of HBV and HBsAg-positive father to infant and the rate of neonatal cord blood HBV-DNA
[J].Chinese Journal of Epidemiology(中华流行病学杂志),2010,31(2):159-162.(in Chinese)

[20]TIAN Y,KUO C F,CHEN W L,et al.Enhancement of hepatitis B virus replication by androgen and its receptor in mice.
[J].J Virol,2012,86(4):1904-1910.

[21]WANG S H,YEH S H,LIN W H,et al.Estrogen Receptor α Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor4α
[J].Gastroenterology,2012,10.

[22]WANG Liang,OUYANG Qiqi,LI Qian,et al(王亮,欧阳奇琦,李茜,等).Influence of Alcohol on Rat Blood-testis Barrier after Transfecting Epithelial Cells of Seminiferous Tubules with HBV DNA
[J].Progress in Modern Biomedicine(现代生物医学进展),2010,10(1):19-22.(in Chinese)

[23]XIE Y,ZHAI J,DENG Q,et al.Entry of hepatitis B virus: mechanism and new therapeutic target
[J].Pathol Biol(Paris),2010,58(4):301-307.

[24]ZHAO Eryong,CHEN Shiling,SUN Ling,et al(赵二勇,陈士岭,孙玲,等).Influence of chronic HBV infection in the husband on the outcome of IVF-ET treatment
[J].Journal of Southern Medical University(南方医科大学学报),2007,27:1827-1829.(in Chinese)

[25]LAM P M,SUEN S H,LAO T T,et al.Hepatitis B infection and outcomes of in vitro fertilization and embryo transfer treatment
[J].Fertil Steril,2010,93:480-485.

[26]FEI Qianjin,HUANG Xuefeng,YANG Haiyan,et al(费前进,黄学锋,杨海燕,等).The outcome of ICSI and IVF cycles of HBsAg-positive carrier males
[J].Chinese Journal of Andrology(中国男科学杂志),2008,22(1):36-38.(in Chinese)

[27]NI Lili(倪丽莉).Study on in vitro fertilization outcome of HBV carriers and the health of mother and offspring
[D].Dissertation Submitted to Zhejiang University for the Master Degree(浙江大学硕士学位论文),2009.7-28.(in Chinese)
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