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浙江大学学报(医学版)  2013, Vol. 42 Issue (2): 224-231    DOI: 10.3785/j.issn.1008-9292.2013.02.015
综述     
哺乳动物促性腺激素抑制激素的生殖内分泌调节与行为作用
孟凡森,陈学群,杜继曾
浙江大学医学院基础医学系,浙江 杭州 310058
Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians
MENG Fan-Sen, CHEN Xue-Qun, DU Ji-Zeng
Department of Basic Medical Sciences,Zhejiang University School of Medicine,Hangzhou 310058,China
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摘要:

哺乳动物中促性腺激素抑制激素(gonadotropin-inhibitory hormone,GnIH)同源物(RF-amide related peptide,RFRP)的神经元胞体主要存在于下丘脑背内侧核(dorsomedial hypothalamic nucleus,DMH),其神经纤维主要投射到视前区(preoptic area,POA)和下丘脑正中隆起,其受体主要分布在下丘脑。RFRP神经元投射到促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)神经元上;最终,RFRP和GnRH共同完成哺乳动物生殖轴功能调节。

关键词: 促性腺激素抑制激素促性腺激素释放激素生殖应激摄食    
Abstract:

RF-amide related peptide(RFRP) is the orthologue of gonadtropin-inhibitory hormone(GnIH) in mammals.The bodies of RFRP cell are located in the dorsomedial nucleus of the hypothalamus(DMH) and the fibers project to preoptic area(POA) and median eminence of the hypothalamus.Its receptor mainly distributes in hypothalamus.RFRP fibers project to GnRH cells to regulate mammalian reproduction axis.This paper reviews the progress of current researches on RFRP in regulation of animal behaviors,including reproduction,food intake,anxiety and stress response.

Key words: Gonadotropin-inhibitory hormone    Gonadotropin-releasing hormone    Reproduction    Stress    Food intake
收稿日期: 2012-02-08 出版日期: 2013-03-25
:  Q 492  
基金资助:

国家重点基础研究发展计划资助项目(2012 CB518200).

通讯作者: 陈学群(1963-),女,教授,博士生导师,从事生理学与神经生物学研究     E-mail: chewyg@zju.edu.cn
作者简介: 孟凡森(1988-),男,硕士生.
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引用本文:

孟凡森, 陈学群, 杜继曾. 哺乳动物促性腺激素抑制激素的生殖内分泌调节与行为作用[J]. 浙江大学学报(医学版), 2013, 42(2): 224-231.

MENG Fan-Sen, CHEN Xue-Qun, DU Ji-Zeng. Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians. Journal of ZheJiang University(Medical Science), 2013, 42(2): 224-231.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2013.02.015        http://www.zjujournals.com/med/CN/Y2013/V42/I2/224


[1]MATSUO H,BABA Y,NAIR R M,et al.Structure of the porcine LH- and FSH-releasing hormone.I.The proposed amino acid sequence
[J].Biochem Biophys Res Commun,1971,43(6):1334-1339.


[2]BURGUS R,BUTCHER M,AMOSS M,et al.Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor(LRF)(LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation)
[J].Proc Natl Acad Sci USA,1972,69(1):278-282.

[3]TSUTSUI K,SAIGOH E,UKENA K,et al.A novel avian hypothalamic peptide inhibiting gonadotropin release
[J].Biochem Biophys Res Commun,2000,275(2):661-667.

[4]BENTLEY G E,TSUTSUI K,KRIEGSFELD L J.Recent studies of gonadotropin-inhibitory hormone(GnIH) in the mammalian hypothalamus,pituitary and gonads
[J].Brain Res,2010,1364:62-71.

[5]SMITH J T ,CLARKE I J.Gonadotropin inhibitory hormone function in mammals
[J].Trends Endocrinol Metab,2010,21(4):255-260.

[6]KRIEGSFELD L J,GIBSON E M,WILLIAMS W P,3RD,et al.The roles of RFamide-related peptide-3 in mammalian reproductive function and behaviour
[J].J Neuroendocrinol,2010,22(7):692-700.

[7]CLARKE I J,QI Y,PUSPITA SARI I,et al.Evidence that RF-amide related peptides are inhibitors of reproduction in mammals
[J].Front Neuroendocrinol,2009,30(3):371-378.

[8]LEI ZHI-HAI,L Y(雷志海,李月).Recent studies of gonadotropin-inhibitory hormone
[J].Animal Husbandry & Veterinary Medicine(畜牧与兽医),2008,40(9):60-100.(in Chinese)

[9]DING Haizhen,YU Baosheng(丁海珍,于宝生).Relationship between gonadotropin-inhibitory hormone and hypothalamus-pituitary-gonadal axis
[J].Progress in Modern Biomedicine(现代生物学进展),2010,10(23):4598-4600.(in Chinese)

[10]HINUMA S,SHINTANI Y,FUKUSUMI S,et al.New neuropeptides containing carboxy-terminal RFamide and their receptor in mammals
[J].Nat Cell Biol,2000,2(10):703-708.

[11]UKENA K,IWAKOSHI E,MINAKATA H,et al.A novel rat hypothalamic RFamide-related peptide identified by immunoaffinity chromatography and mass spectrometry
[J].FEBS Lett,2002,512(1-3):255-258.

[12]YOSHIDA H,HABATA Y,HOSOYA M,et al.Molecular properties of endogenous RFamide-related peptide-3 and its interaction with receptors
[J].Biochim Biophys Acta,2003,1593(2-3):151-157.

[13]UBUKA T,LAI H,KITANI M,et al.Gonadotropin-inhibitory hormone identification,cDNA cloning,and distribution in rhesus macaque brain
[J].J Comp Neurol,2009,517(6):841-855.

[14]UBUKA T,MORGAN K,PAWSON A J,et al.Identification of human GnIH homologs,RFRP-1 and RFRP-3,and the cognate receptor,GPR147 in the human hypothalamic pituitary axis
[J].PLoS One,2009,4(12):e8400.

[15]UKENA K,TSUTSUI K.Distribution of novel RFamide-related peptide-like immunoreactivity in the mouse central nervous system
[J].Neurosci Lett,2001,300(3):153-156.

[16]JOHNSON M A,TSUTSUI K and FRALEY G S.Rat RFamide-related peptide-3 stimulates GH secretion,inhibits LH secretion,and has variable effects on sex behavior in the adult male rat
[J].Horm Behav,2007,51(1):171-180.

[17]KRIEGSFELD L J,MEI D F,BENTLEY G E,et al.Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
[J].Proc Natl Acad Sci USA,2006,103(7):2410-2415.

[18]RIZWAN M Z,PORTEOUS R,HERBISON A E,et al.Cells expressing RFamide-related peptide-1/3,the mammalian gonadotropin-inhibitory hormone orthologs,are not hypophysiotropic neuroendocrine neurons in the rat
[J].Endocrinology,2009,150(3):1413-1420.

[19]CLARKE I J,SARI I P,QI Y,et al.Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion
[J].Endocrinology,2008,149(11):5811-5821.

[20]DARDENTE H,BIRNIE M,LINCOLN G A,et al.RFamide-related peptide and its cognate receptor in the sheep: cDNA cloning,mRNA distribution in the hypothalamus and the effect of photoperiod
[J].J Neuroendocrinol,2008,20(11):1252-1259.

[21]SMITH J T,SHAHAB M,PEREIRA A,et al.Hypothalamic expression of KISS1 and gonadotropin inhibitory hormone genes during the menstrual cycle of a non-human primate
[J].Biol Reprod,2010,83(4):568-577.

[22]SMITH J T,COOLEN L M,KRIEGSFELD L J,et al.Variation in kisspeptin and RFamide-related peptide(RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium for seasonal breeding in the sheep
[J].Endocrinology,2008,149(11):5770-5782.

[23]WU M,DUMALSKA I,MOROZOVA E,et al.Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2-gonadotropin-releasing hormone neurons via a direct postsynaptic mechanism
[J].J Physiol,2009,587(Pt 7):1401-1411.

[24]BONINI J A,JONES K A,ADHAM N,et al.Identification and characterization of two G protein-coupled receptors for neuropeptide FF
[J].J Biol Chem,2000,275(50):39324-39331.

[25]DOCKRAY G J.The expanding family of -RFamide peptides and their effects on feeding behaviour
[J].Exp Physiol,2004,89(3):229-235.

[26]TSUTSUI K.A new key neurohormone controlling reproduction,gonadotropin-inhibitory hormone(GnIH): Biosynthesis,mode of action and functional significance
[J].Prog Neurobiol,2009,88(1):76-88.

[27]ANDERSON G M,RELF H L,RIZWAN M Z,et al.Central and peripheral effects of RFamide-related peptide-3 on luteinizing hormone and prolactin secretion in rats
[J].Endocrinology,2009,150(4):1834-1840.

[28]DUCRET E,ANDERSON G M,HERBISON A E.RFamide-related peptide-3,a mammalian gonadotropin-inhibitory hormone ortholog,regulates gonadotropin-releasing hormone neuron firing in the mouse
[J].Endocrinology,2009,150(6):2799-2804.

[29]UBUKA T,INOUE K,FUKUDA Y,et al.Identification,expression,and physiological functions of Siberian hamster gonadotropin-inhibitory hormone
[J].Endocrinology,2012,153(1):373-385.

[30]MURAKAMI M,MATSUZAKI T,IWASA T,et al.Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats
[J].J Endocrinol,2008,199(1):105-112.

[31]PINEDA R,GARCIA-GALIANO D,SANCHEZ-GARRIDO M A,et al.Characterization of the inhibitory roles of RFRP3,the mammalian ortholog of GnIH,in the control of gonadotropin secretion in the rat: in vivo and in vitro studies
[J].Am J Physiol Endocrinol Metab,2010,299(1):E39-46.

[32]KADOKAWA H,SHIBATA M,TANAKA Y,et al.Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone(LH) secretion from the pituitary as well as pulsatile LH secretion in bovines
[J].Domest Anim Endocrinol,2009,36(4):219-224.

[33]SARI I P,RAO A,SMITH J T,et al.Effect of RF-amide-related peptide-3 on luteinizing hormone and follicle-stimulating hormone synthesis and secretion in ovine pituitary gonadotropes
[J].Endocrinology,2009,150(12):5549-5556.

[34]ZHAO S,ZHU E,YANG C,et al.RFamide-related peptide and messenger ribonucleic acid expression in mammalian testis: association with the spermatogenic cycle
[J].Endocrinology,2010,151(2):617-627.

[35]BENTLEY G E,UBUKA T,MCGUIRE N L,et al.Gonadotrophin-inhibitory hormone: a multifunc-tional neuropeptide
[J].J Neuroendocrinol,2009,21(4):276-281.

[36]GIBSON E M,HUMBER S A,JAIN S,et al.Alterations in RFamide-related peptide expression are coordinated with the preovulatory luteinizing hormone surge
[J].Endocrinology,2008,149(10):4958-4969.

[37]SINGH P,KRISHNA A,SRIDARAN R,et al.Immunohistochemical localization of GnRH and RFamide-related peptide-3 in the ovaries of mice during the estrous cycle
[J].J Mol Histol,2011,42(5):371-381.

[38]REVEL F G,SABOUREAU M,PEVET P,et al.RFamide-related peptide gene is a melatonin-driven photoperiodic gene
[J].Endocrinology,2008,149(3):902-912.

[39]MASON A O,DUFFY S,ZHAO S,et al.Photoperiod and reproductive condition are associated with changes in RFamide-related peptide(RFRP) expression in Syrian hamsters(Mesocricetus auratus)
[J].J Biol Rhythms,2010,25(3):176-185.

[40]PAUL M J,PYTER L M,FREEMAN D A,et al.Photic and nonphotic seasonal cues differentially engage hypothalamic kisspeptin and RFamide-related peptide mRNA expression in Siberian hamsters
[J].J Neuroendocrinol,2009,21(12):1007-1014.

[41]UBUKA T,BENTLEY G E,UKENA K,et al.Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain
[J].Proc Natl Acad Sci USA,2005,102(8):3052-3057.

[42]TACHIBANA T,SATO M,TAKAHASHI H,et al.Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks
[J].Brain Res,2005,1050(1-2):94-100.

[43]QI Y,OLDFIELD B J,CLARKE I J.Projections of RFamide-related peptide-3 neurones in the ovine hypothalamus,with special reference to regions regulating energy balance and reproduction
[J].J Neuroendocrinol,2009,21(8):690-697.

[44]KAEWWONGSE M,TAKAYANAGI Y,ONAKA T.Effects of RFamide-related peptide(RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats
[J].J Neuroendocrinol,2011,23(1):20-27.

[45]KOTLINSKA J,PACHUTA A,BOCHENSKI M,et al.Dansyl-PQRamide,a putative antagonist of NPFF receptors,reduces anxiety-like behavior of ethanol withdrawal in a plus-maze test in rats
[J].Peptides,2009,30(6):1165-1172.

[46]PAPARGIRIS M M,RIVALLAND E T,CLARKE I J,et al.Evidence that RF-amide related peptide-3 is not a mediator of the inhibitory effects of psychosocial stress on gonadotrophin secretion in ovariectomised ewes
[J].J Neuroendocrinol,2011,23(3):208-215.

[47]FAN J M,CHEN X Q,JIN H,et al.Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring
[J].Neuroscience,2009,159(4):1363-1373.

[48]KIRBY E D,GERAGHTY A C,UBUKA T,et al.Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats
[J].Proc Natl Acad Sci USA,2009,106(27):11324-11329.
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