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浙江大学学报（医学版）
浙江大学学报（医学版）  2013, Vol. 42 Issue (2): 192-196    DOI: 10.3785/j.issn.1008-9292.2013.02.010
论著     
广泛性焦虑症与抑郁症患者皮肤交感反应对照研究
蒋红，王灵，王新玲，冯锐，章迎春，屠玲玲，陈炜
浙江大学医学院附属邵逸夫医院精神卫生科，浙江 杭州 310016
Comparison of skin sympathetic reaction in patients with generalized anxiety disorder and with major depression disorder
JIANG Hong, WANG Ling, WANG Xin-Ling, FENG Rui, ZHANG Ying-Chun, TU Ling-Ling, CHEN Wei
Department of Psychiatry，Sir Run Run Shaw Hospital，Zhejiang University School of Medicine，Hangzhou 310016,China
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摘要：

目的：探讨广泛性焦虑症(GAD)与抑郁症(MDD)患者皮肤交感反应（SSR）的差异。
方法：对30例GAD患者、30例MDD患者，分别在治疗前及治疗8周后检测 SSR的潜伏期与波幅，并与30例正常对照组（HC）比较。
结果：GAD组治疗前SSR潜伏期低于HC组，波幅明显高于HC组，差异均有显著性意义（P<0.05）；MDD组治疗前潜伏期比HC组明显延长，波幅明显低平，差异均有显著性意义(P<0.05)，而且有2例未引出波形。经治疗后，GAD组潜伏期水平较治疗前延长，接近于对照组水平；波幅较治疗前降低，但高于对照组（P＞0.05）；MDD组潜伏期较治疗前降低（P<0.05），差异均有显著性意义。MDD组的SSR潜伏期明显延长，GAD组潜伏期缩短，两组比较差异有统计学意义(P<0.05)；MDD组波幅明显低平，而GAD组波幅明显增高，两组比较差异有统计学意义(P<0.001)。相关分析显示，SSR各参数与HAMA和HAMD呈正相关，相关系数分别为0.57和0.73。
结论：GAD与MDD在SSR的电生理检测方面有显著性差异。
关键词： 广泛性焦虑;  抑郁症;  表现焦虑量表;  精神病状态评定量表;  皮肤交感反应;  汉密尔顿抑郁量表;  汉密尔顿焦虑量表    
Abstract:

Objective： To compare skin sympathetic response(SSR) between patients with generalized anxiety disorder(GAD) and patients with major depression disorder(MDD).
Methods： The latency and amplitude of SSR wave were measured in 30 GAD patients and 30 MDD patients，before and after 8-week treatment of anti-anxiety or anti-depression drugs.Thirty age and sex-matched healthy subjects served as healthy controls(HC).
Results： Before the treatment，the latency of SSR in GAD patients was significantly shorter than that in HC group，while the amplitude was significantly higher than that in the HC(P<0.05).In MDD group，the latency before the treatment was significantly longer than that in the HC，while the amplitude was significantly lower than that in the HC(P<0.05).After treatment，the latency of SSR in GAD group was extended compared to the baseline level，and close to the level of the HC.The amplitude of SSR in GAD group became lower after treatment，but still higher than that of control group.The latency of SSR in MDD patients was significantly shorter after treatment compared to baseline level(P<0.05).In addition，the latency of SSR in MDD group was still longer than that in GAD group(P<0.05); meanwhile，the amplitude of SSR in MDD group was significantly lower that in GAD group(P<0.001).SSR parameters were positively correlated with HAMA and HAMD scores with a correlation coefficient of 0.57 and 0.73，respectively.
Conclusion： There are significant differences in SSR parameters between patients with GAD and patients with MDD，indicating that SSR can be used as an objective index to distinguish anxiety from depression.
Key words: Anxiety disorders    Depression    Depressive disorder    Manifest anxiety scale    Psychiatric status rating scales    Sympathetic skin response    Hamilton anxiety scale    Hamilton depressive scale
收稿日期: 2011-12-09 出版日期: 2013-03-25
:  R 749.72  
基金资助:

浙江省科技计划重点基金资助项目（2006C23016）；浙江省卫生厅科研基金资助项目（2010KYB063）;浙江省教育厅一般研究基金资助项目（Y201017316）.
作者简介: 蒋红（1975-），女，大学本科，副主任医师，从事神经电生理研究.
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引用本文:

蒋红, 王灵, 王新玲, 冯锐, 章迎春, 屠玲玲, 陈炜. 广泛性焦虑症与抑郁症患者皮肤交感反应对照研究[J]. 浙江大学学报（医学版）, 2013, 42(2): 192-196.

JIANG Hong, WANG Ling, WANG Xin-Ling, FENG Rui, ZHANG Ying-Chun, TU Ling-Ling, CHEN Wei. Comparison of skin sympathetic reaction in patients with generalized anxiety disorder and with major depression disorder. Journal of ZheJiang University(Medical Science), 2013, 42(2): 192-196.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2013.02.010    或    http://www.zjujournals.com/med/CN/Y2013/V42/I2/192


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