目的:通过基于磁共振图像的体积测量技术测量正常成人的纹状体体积,探讨国人纹状体随年龄退化的规律,以及男女两性和左右侧纹状体的体积差异.方法:年龄跨度在18至70岁的健康成人100例,运用磁共振快速扰相梯度回波序列获得全脑的高分辨率三维结构图像,使用Mricro软件在结构像上人工勾划尾状核和壳核的边界,计算出双侧尾状核和壳核的体积.结果:健康成人双侧尾状核体积为(8.42±0.88 )cm~3,两侧壳核体积为(8.90±0.89)cm~3.尾状核(r=-0.727,P<0.001)和壳核(r=-0.709,P<0.001)的体积均随着年龄的增长而缩小,平均每年缩小约0.52;和0.50;.男女性之间的尾状核和壳核体积均未发现显著差异.男性纹状体体积每年减少约0.55;,女性每年减少约0.48;.无论男性还是女性,左侧尾状核(t=4.43,P<0.001)和壳核(t=4.88,P<0.001)体积均较右侧大.结论:成人纹状体体积随着年龄增长而缩小.男女性之间的纹状体平均体积没有明显差异,但是男性纹状体较女性退化稍快.纹状体的体积分布存在左侧优势的特性,左侧纹状体体积比右侧大.
Objective: To examine the age,sex,and hemispheric differences in volume of the striatum by MRI in healthy adults. Methods: The volumes of the bilateral caudate nucleus and putamen were measured on MR images in 100 healthy right-handed adults (18-70 y). Results: The volume of bilateral caudate nucleus and putamen in healthy adults was (8.42±0.88) cm~3 and (8.90±0.89) cm~3,which were decreased with aging (for caudate nucleus r=-0.727,P<0.001; for putamen r=-0.709,P<0.001).The average annual shrinkage rate was 0.52; in the caudate nucleus and 0.50; in the puatmen.There were no gender differences in the volume of the striatum,however,the age-related shrinkage of the striatum was more evident in men than that in women.The volume of the left caudate nucleus (t=4.43,P<0.001) and the putamen (t=4.88,P<0.001) was greater than that of its right counterpart. Conclusion: Bilateral age-related shrinkage of the striatum is found in healthy adults,which is more evident in men than that in women.In both sexes,significant leftward asymmetry in volume of the caudate nucleus and the putamen is found.
国家自然科学基金(30570536;30900358);浙江省医药卫生优秀青年科技人才专项科研基金(2009QN005)
徐敬峰;徐晓俊;汪启东;赵艺蕾;孔德兴;张敏鸣. 健康成人纹状体体积的磁共振在体测量研究 [J]. 浙江大学学报（医学版）, 2010, 39(2): 130-135.
https://www.zjujournals.com/med/CN/Y2010/V39/I2/130
Cited
