目的:探索米索前列醇在晚期妊娠引产中的效果和安全性。方法:有引产指征而无使用米索前列醇引产禁忌征的单胎、头位、胎膜完整的晚期妊娠孕妇100例,随机分为A组和B组各50例,A组阴道后穹窿放入米索前列醇50 μg,12 h后如无正规宫缩,则加用催产素2.5 u,加入5%葡萄糖500 ml中静滴引产,B组仅用催产素2.5 u引产。结果:A组引产成功率比B组高,有显著差异,但两组的分娩结局、新生儿评分、羊水粪染无显著差异。结论:用米索前列醇与催产素联合用于晚期妊娠引产,可缩短产程,提高引产效果,为晚期妊娠引产的安全有效的方法。
Objective:To study the efficacy and safety of misoprostol for labor induction of late pregnancy.Methods:One hundred pregnant women with single pregnancy,vertex presence and intact membrane were randomly assigned into two groups,fifty for each.Misoprostol (50 μg) was placed in the posterior vaginal fornix in group A.If there was no regular uterine contraction after 12 hours,oxytocin 2.5 u in 5% glucose 500 ml was injected.Subjects in group B were only given oxytocin 2.5 u. Results:The sucesess rate of labor induction was higher in group A than that in group B with significant difference,but there were no significant differences between the two groups in delivery results, neonatorum scores and meonieum in anmiotic fluid.Conclusion:Combination of misoprostol with oxytocin can shorten time of delivery process and improve efficacy of labor induction.It is efficient and safe for late pregnancy.
叶群英. 米索前列醇与催产素联合用于晚期妊娠引产效果观察[J]. 浙江大学学报（医学版）, 1999, 28(4): 158-159.
YIE Qun-ying. The Combination of Misoprostol with Oxytocin in Labor Induction of Late Pregnancy. Journal of ZheJiang University(Medical Science), 1999, 28(4): 158-159.