Objective:To study the efficacy and safety of misoprostol for labor induction of late pregnancy.Methods:One hundred pregnant women with single pregnancy,vertex presence and intact membrane were randomly assigned into two groups,fifty for each.Misoprostol (50 μg) was placed in the posterior vaginal fornix in group A.If there was no regular uterine contraction after 12 hours,oxytocin 2.5 u in 5% glucose 500 ml was injected.Subjects in group B were only given oxytocin 2.5 u. Results:The sucesess rate of labor induction was higher in group A than that in group B with significant difference,but there were no significant differences between the two groups in delivery results, neonatorum scores and meonieum in anmiotic fluid.Conclusion:Combination of misoprostol with oxytocin can shorten time of delivery process and improve efficacy of labor induction.It is efficient and safe for late pregnancy.