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浙江大学学报(医学版)  1999, Vol. 28 Issue (1): 8-11    DOI: 10.3785/j.issn.1008-9292.1999.01.003
论著     
超声监测子宫内膜预测排卵障碍妇女促排卵疗效
朱依敏, 周馥贞
浙江医科大学附属妇产科医院妇科
Sonographic Mornitoring of Endometrium to Predict the Efficacy of Ovulation Induction Therapy in Anovulatory Women
Zhu Yimin, Zhou Fuzhen
Department of Gynecology, Obstetrics and Gynecology Affiliated Hospital, Zhejiang Medical University
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摘要:

目的:评估阴道超声监测排卵前子宫内膜厚度及回声类型,对排卵障碍妇女促排卵疗效的预测价值。方法:研究对象为68例排卵障碍妇女。39例采用促性腺激素释放激素激动剂(GnRH-a)+人绝经期促性腺激素(HMG)超短方案,29例采用常规HMG方案作促排卵治疗。阴道超声监测卵泡发育及注射人绒毛膜促性腺激素(HCG)日子宫内膜厚度和回声类型。注射HCG后每例均行宫腔内人工授精(IUI)。以妊娠情况评定促排卵疗效。结果:完成促排卵治疗共56例,其中GnRH-a超短方案组31例,常规HMG组25例,子宫内膜厚≤10 mm者分别为2例和4例,均未妊娠;≥15 mm者分别为5例和2例,持续妊娠率均为0;11.0~14.9 mm者分别为24例和19例,持续妊娠率分别为41.7%和36.8%。子宫内膜回声呈三线型者各有21例和17例,持续妊娠率分别为47.6%和35.3%;同质型者各有10例和8例,持续妊娠率分别为0和12.5%。结论:排卵障碍妇女促排卵治疗时,注射HCG日阴道超声检测子宫内膜的厚度及回声类型,可以成功地预测IUI的妊娠率,当子宫内膜厚≤10 mm或≥15 mm或为同质型回声时,预示妊娠率低下。

关键词: 子宫内膜/超声检查排卵探测女性不育/诊断促性腺激素类/治疗应用    
Abstract:

Objective:To judge the value of predicting the effects of ovulation induction therapy on anovulatory women by transvaginal sonography to measure periovulatory endometrial thickness and echo pattern.Methods:Sixty-eight anovulatory women were included in the study.Ovulation was induced in 39 patients with ultrashort protocol of GnRH a+HMG and in 29 patients with HMG alone.With transvaginal sonography the follicular development and endometrial thickness and echo pattern were mornitored on the day of HCG injection.The effect of treatment was evaluated by pregnant rate.Results:Fifty-six infertile women completed the ovulation induction cycles.Thirty-one patients were stimulated with ultra-short GnRH a+HMG regimen and twenty five with conventional HMG regimen.On the day of HCG administration,the cases with endometrial thickness ≤10 mm were two and four in two regimen respectively.None of them was pregnant.The cases with endometrial thickness ≥15 mm were five and two respectively.None of them was successful in ongoing pregnancy.The cases with endometrial thickness between 11.0 mm and 14.9 mm were twenty four and nineteen respectively.The ongoing pregnancy rates(PRs) were 41.7% and 36.8% respectively.The ongoing PRs were significantly higher in those endometrium with trilaminar patterns than in those homogeneous patterns (47.6% and 35.3% versus 0 and 12.5%, P<0.05).Conclusion:Induction therapy for anovulatory women in ovulation measuring endometrial thickness and echo patterns by transvaginal sonography on the day of HCG administration is successful in prediction of pregnant possibility.Endometrial thickness ≤10 mm or ≥15 mm or homogeneous pattern predicts a lower PRs.

Key words: Endometrium/ultrasonogr    Ovulation detection Infertility    Female/diag    Gonadotropin/ther use
收稿日期: 1998-03-27 出版日期: 1999-01-25
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引用本文:

朱依敏, 周馥贞. 超声监测子宫内膜预测排卵障碍妇女促排卵疗效[J]. 浙江大学学报(医学版), 1999, 28(1): 8-11.

Zhu Yimin, Zhou Fuzhen. Sonographic Mornitoring of Endometrium to Predict the Efficacy of Ovulation Induction Therapy in Anovulatory Women. Journal of ZheJiang University(Medical Science), 1999, 28(1): 8-11.

链接本文:

https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1999.01.003        https://www.zjujournals.com/med/CN/Y1999/V28/I1/8

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