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浙江大学学报（医学版）
浙江大学学报（医学版）  1998, Vol. 27 Issue (4): 151-154    DOI: 10.3785/j.issn.1008-9292.1998.04.003
论著     
成人急性淋巴细胞白血病的MIC分型与临床预后分析
叶琇锦, 林茂芳, 周国华, 谢万灼, 梁毅, 陈志妹, 金洁
浙江医科大学附属第一医院血液病科
MIC Classification and Its Clinical and Prognostic Analysis of Acute Lymphocytic Leukemia
Ye Xiujin, Lin Maofang, Zhou Guohua, et al
Department of Hematology, First Affiliated Hospital, Zhejiang Medical University
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摘要： 目的:分析成人急性淋巴细胞白血病(ALL)的MIC分型与临床及预后的关系。方法:40例ALL患者按常规骨髓涂片及细胞化学染色进行形态学分析,并用单克隆抗体间接免疫荧光法检测细胞免疫表型,用R显带技术分析13例的细胞遗传学。结果:FAB分型ALL-LI型3例,L2型35例,L3型2例。细胞免疫表型符合T细胞系ALL 13例(伴髓系表达2例),B细胞系ALL 21例(伴髓系表达4例),T/B细胞系共同表达ALL 5例(伴髓系表达1例),未分化型急性白血病1例。13例中有8例核型异常。结论:ALL患者形态学检查结合免疫学和细胞遗传学综合分析,有利于明确白血病细胞克隆的来源,有利于估计预后,并指导治疗。
关键词： 急性淋巴细胞白血病/诊断;  急性淋巴细胞白血病/病理学;  急性淋巴细胞白血病/免疫学;  急性淋巴细胞白血病/遗传学    
Abstract: Objective: To analyse the relationship of morphology-immunology-cytogene (MIC) typing classification of adult acute leukemia (ALL) to its clinical significance and prognosis. Methods: The morphology of 40 ALL patients was examined by conventional bone marrow smearing and cytochemistry staining, and their immunophenotype by indirect imrnunofluoresence assay with monoclonal antibodies (McAbs). The cytogenetics of 13 cases was analyzed by R-banding technique. Results: There were 3 cases with ALL-L1, 35 cases with ALL-L2 and 2 cases with ALL-L3 according to FAB classification. It was found that T-cell antigens were expressed in 13 cases with myeloid antigens in 2 cases, B-cell antigens were co-expressed in 21 cases with myeloid antigens in 4 cases and T/B cell antigens were co-expressed in 5 cases with myeloid antigens in 1 case. One case with undifferentiated acute leukemia was found. Abnormal chromosome karyotypes of 8 cases were found among 13 cases. Conclusion: The comprehensive analysis of MIC and the clinical features of ALL is of value in the prognosis and treatment of the disease.
Key words: Leukemia, lymphocytic, acute/diag    Leukemia, lymphocytic, acute/pathol    Leukemia, lymphocytic, acute/immunol    Leukemia, lymphocytic, acute/genet
收稿日期: 1997-09-01 出版日期: 1998-07-25
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叶琇锦, 林茂芳, 周国华, 谢万灼, 梁毅, 陈志妹, 金洁. 成人急性淋巴细胞白血病的MIC分型与临床预后分析[J]. 浙江大学学报（医学版）, 1998, 27(4): 151-154.

Ye Xiujin, Lin Maofang, Zhou Guohua, et al. MIC Classification and Its Clinical and Prognostic Analysis of Acute Lymphocytic Leukemia. Journal of ZheJiang University(Medical Science), 1998, 27(4): 151-154.

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https://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.1998.04.003    或    https://www.zjujournals.com/med/CN/Y1998/V27/I4/151

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