Serum concentrations of total bile acids(TBA) in newborns with septicemia and correlation of those concentrations with the results of other routine liver tests including alanine aminotransferase(ALT),total bilirubin(TB), and γ-glutamyl transpeptidase(γ-GT) were studied in 77 cases of neonatal septicemia, with 19 non-infections newborns as controls. The results showed that serum TBA levels significantly increased in septicemia as compared with those of controls(P<0.01) and that serum TBA concentrations in 35 elevated cases sharply declined 7~10 days after effective antibiotic therapy(P<0.01). In addition, we found that TBA concentration in septicemia with septic shock was significantly higher than that with non-septic shock(P<0.05).There were no correlations between the concentration of serum TBA and those of ALT,TB and γ-GT. The study suggested that serum TBA levels in neonatal septicemia remarkedly elevated during the acute stage and apparently decreased during the convalescent stage. Serum TBA levels might reflect the seventy of neonatal septicemia to a certain extent.
魏健, 沈健. 新生儿败血症血清总胆汁酸的变化及其临床意义[J]. 浙江大学学报（医学版）, 1997, 26(4): 158-160.
Wei Jian, Shen Jian. CHANGES OF SERUM TOTAL BILE ACIDS IN NEONATAL SEPTICEMIA AND ITS CLINICAL SIGNIFICANCE. Journal of ZheJiang University(Medical Science), 1997, 26(4): 158-160.